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Evidence on Antibiotic Effectiveness for Sore Throat Relief

Learn how to find the best evidence on the effectiveness of antibiotics for relieving symptoms of sore throat. Formulate a focused question, create a search strategy, and explore databases like PubMed and The Cochrane Library.

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Evidence on Antibiotic Effectiveness for Sore Throat Relief

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  1. Finding the Best Evidence Owen Coxall University of Oxford Bodleian Health Care Libraries

  2. Session objectives • Formulate a focused question • Turn a focused question into a search strategy • Search TRIP & PubMed

  3. Formulate a focussedquestion Patient / Problem / Population Intervention Comparison Outcome

  4. Scenario Gerry, has had a bad throat for a few days and it’s making him feel miserable. He goes to his friendly GP wanting some antibiotics. However, his doctor isn’t sure whether there’s any benefit in prescribing them. What’s the evidence?

  5. Focused question P: sore throat I: antibiotics C: no antibiotics O: symptom relief Are antibiotics effective in relieving symptoms of sore throat?

  6. Quick searchDemonstration www.tripdatabase.com

  7. Hands-on • Formulate a focused question • Use your own question or one of the examples in your workbook • Record the search terms you’re using • Run a quick search on TRIPwww.tripdatabase.com

  8. Run a full search strategyWhy bother? • Too few results • Too many results • Irrelevant results • Submitting a funding proposal • Writing a guideline • Conducting a systematic review

  9. Develop a search strategy Using OR then ANDto broaden then focus the search and and

  10. Combine terms withOR Pharyngitis OR sore throat – either term can be present pharyngitis Sore throat

  11. Combine terms withAND Antibiotics AND sore throat – both terms must be present antibiotics sore throat

  12. PubMed demonstrationwww.pubmed.gov

  13. Searching tips:PubMed Subject searching - use MeSH • Subject headings added to articles on Medline • Search the MeSH Database • Finding similar articles – use the ‘Related articles’ link

  14. Hands-on • Take your focused question: • Run further searches on PubMedhttp://www.pubmed.gov

  15. The Cochrane Library • Specialist database including articles on clinical and cost effectiveness of interventions: • Systematic reviews – Cochrane Database of Systematic Reviews & DARE • RCTs – Central • Economic evaluations - NHSEED • Free access in the UK at http://www.thecochranelibrary.com • Other countries check “access options” at http://www.cochrane.org

  16. The Cochrane Library:www.thecochranelibrary.com

  17. Hands-on • Take your focused question: • Run a search on the Cochrane Libraryhttp://www.thecochranelibrary.com

  18. Help • PubMed • Short online tutorials • Quick guides to PubMed – basics, MeSH search and MyNCBI http://www.nlm.nih.gov/bsd/disted/pubmed.html • The Cochrane Library • Online tutorial – several languages http://www3.interscience.wiley.com/aboutus/demo/ • User guides – several languages http://www3.interscience.wiley.com/cgi-bin/mrwhome/106568753/HELP_Cochrane.html

  19. Resources • Cochrane Librarywww.thecochranelibrary.com • PubMedwww.pubmed.gov • TRIPwww.tripdatabase.com • Other sources – CEBM web-site – EBM toolswww.cebm.net

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