1 / 16

Biofilms, Methylation & Heavy Metal Detoxification in Lyme Disease

Biofilms, Methylation & Heavy Metal Detoxification in Lyme Disease. Overview. Biofilms Gastrointestinal physiology Definition of Biofilms Examples Prevalence Treatment B. Heavy Metals Prevalence Signs & symptoms Testing Treatment options Methylation in non-responders C. Conclusion.

fanet
Download Presentation

Biofilms, Methylation & Heavy Metal Detoxification in Lyme Disease

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Biofilms, Methylation & Heavy Metal Detoxification in Lyme Disease Raj Patel, M.D.

  2. Overview • Biofilms • Gastrointestinal physiology • Definition of Biofilms • Examples • Prevalence • Treatment • B. Heavy Metals • Prevalence • Signs & symptoms • Testing • Treatment options • Methylation in non-responders • C. Conclusion Raj Patel, M.D.

  3. B. Biofilms in Lyme Disease 1. GI Physiology:Structure of normal intestinal lining Raj Patel, M.D.

  4. Raj Patel, M.D.

  5. B. Biofilms in Lyme Disease 1. GI Physiology:Structure of intestinal lining in Gluten intolerance Raj Patel, M.D.

  6. Raj Patel, M.D.

  7. B. Biofilms in Lyme Disease 1. GI Physiology Microbial Flora I. One hundred trillion bacteria in gut comprises 500 different species II. Disruption early leads to immune problems, allergies, and autoimmunity later III. Functions: modulates immune system destroys toxins introduced with food suppress growth of pathogenic bacteria production of key vitamins digestion and absorption of carbohydrates prevention of allergies prevention of inflammatory bowel disease Raj Patel, M.D.

  8. B. Biofilms in Lyme Disease 2. Definition a. Community of bacteria and other organisms surrounded by a extracellular polymeric substance (EPS) b. EPS is composed of DNA, protein, and polysaccharides. Its negative charge attracts Ca/Mg/Fe to strengthen it c. Organisms within a biofilm can communicate and exchange genetic material. d. EPS provides resistance to antibiotics requiring 100-1000X higher levels for eradication. “Testing the susceptibility of bacteria in biofilms to antimicrobial agents .” Antimicrobial Agents and Chemo. Nov 1990 e. EPS provides this organisms protection from UV exposure, pH changes, heavy metal toxicity, and phagocytosis. Raj Patel, M.D.

  9. B. Biofilms in Lyme Disease 3. Examples of Biofilms a. Teeth b. Catheters and IV Lines c. Stagnant pools of water, rivers and streams d. Contact lens e. Polluted areas f. Blood (Fry et al) Raj Patel, M.D.

  10. B. Biofilms in Lyme Disease 4. Prevalence of Biofilms a. Autism Spectrum Disorders b. Chronic Lyme Disease c. Chronic Fatigue Immune Dysfunction Syndrome d. Fibromyalgia e. Autoimmune Illness Raj Patel, M.D.

  11. Raj Patel, MD

  12. B. Biofilms in Lyme Disease 3. Examples of Biofilms Raj Patel, M.D.

  13. Raj Patel, MD

  14. Raj Patel, MD

  15. B. Biofilms in Lyme Disease • 5. Role of EDTA in Dissolving Biofilm • a. EDTA serves to bind and remove the Ca/Mg/Fe holding biofilms together • b. Staph biofilms could not be eradicated by Vancomycin or EDTA alone. Together the two agents successfully removed the biofilm (Kim 2005) • c. EDTA and Gentamycin are 1000X more effective at killing Pseudomonas than either agent alone. This effect is completely blocked when Ca or Fe are added (Banin 2005) Raj Patel, M.D.

  16. B. Biofilms in Lyme Disease • 6. Treatment of Biofilms • a. Enzymes • b. EDTA • c. Antimicrobials • Antifungals • d. Fiber • Brown Algae • Modified Citrus Pectin • Activated Charcoal • Zeolite • e. Probiotics • Prebiotics (fresh fruit, legumes, chicory, FOS, inulin) • Supportive nutrients (slippery elm, okra, NAG, ecklona cava, colostrum) • f. Drainage • g. GO SLOW Raj Patel, M.D.

More Related