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Lecture 22 Signaling at the cell surface continued (chapter 15)

Lecture 22 Signaling at the cell surface continued (chapter 15) G-proteins and G-protein coupled receptors Visual cascade and Receptor adaptation. G-protein coupled Receptors: Rhodopsin (visual pigment). out. Retinal (ligand). in. Natural ligand (retinal) is inside the cavity.

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Lecture 22 Signaling at the cell surface continued (chapter 15)

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  1. Lecture 22 Signaling at the cell surface continued (chapter 15) G-proteins and G-protein coupled receptors Visual cascade and Receptor adaptation

  2. G-protein coupled Receptors: Rhodopsin (visual pigment) out Retinal (ligand) in Natural ligand (retinal) is inside the cavity

  3. Why vision is a kind of smell?

  4. 7-TM domain G-protein coupled receptors (short list) a, b adrenergic R Muscarinic AChR Dopamine R Histamine R Prostaglandin PGE1 R GABAB R Substance P R Opiate R ADH (vasopressin VR1) R Angiotensin R Bradykinin R Glucagon R Ca2+ R Olfactory receptors (?) Taste receptors Rhodopsin these ligands come from outside

  5. Beta2 Adrenergic receptor

  6. FRET experiments indicate that activation of G-proteins occurs within seconds

  7. KACh channel is regulated by G beta-gamma Gbg

  8. The intracellular (second) messengers Cyclases Phospholipase Ca2+

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