James K. Murray, Jr., PhD, Associate Professor & Chair, Chemistry Department, Immaculata University Barry F. Stein,

James K. Murray, Jr., PhD, Associate Professor & Chair, Chemistry Department, Immaculata University Barry F. Stein, PhD Senior Project Consultant Mary J. Burch, PhD Project Consultant 1

jmurray@Immaculata.edu steinbf@verizon.net maryjburch@gmail.com 2

Demonstrative Experiments Nano Overview Lessons & lesson plans Adaptation to your class 3

Workshop Content BREAK 4

Workshop Content Continued LUNCH 5

What is Nanotechnology? • The ability to manipulate and control materials at the level of atoms and molecules to design new functionality. The nanoscale: 1nm=10-9m • An enabling science that • applies to all disciplines • blurs the distinction between biology, chemistry, & physics • Nanotechnology will be pervasive in the upcoming decades New career opportunities for students 6

Nano Size Cell Size & Scale http://learn.genetics.utah.edu/content/begin/cells/scale/

Generally nanotechnology deals with structures 100 nanometers or smaller, and involves developing materials or devices within that size. 8

The Economic Driver of the 21st Century • “Nanotechnology’s impact on health, wealth and security of the world’s people is expected to be at least as great as the combined influences in this century of antibiotics, the integrated circuit and human-made polymers.” • Federal Interagency Working Group Report on Nanotechnology 9

What's 100,000 times thinner than a strand of hair? A nanometer. Discover the nanotech boom in Berkeley, where researchers are working to unlock the potential of nanoscience to battle global warming and disease. • http://www.youtube.com/watch?v=S4CjZ-OkGDs 10

1000000 1000 1 1600 1700 1800 1900 2000 Magnification vs. Year 11

Atomic Force Microscope Carbon nanotube 12

As of August 2009, there were more than 1015 manufacturer-identified nanotech products1 13 1The Woodrow Wilson International Center for Scholars

Materials-nanotubes • Life Sciences-drug development & delivery, innovative therapies, diagnostics • Sensors-physical, chemical, biological • Ultra-high speed computing, Molecular Electronics • Nanomachines • Green technology: Fuel cells, solar cells, new light sources, microbial cleanup, filtration 15

Clean Water Challenge Now! Nanofiltration Nano for Remediation • Nanostructured • Arrays of capillaries • Carbon nanotubes • Nanoreactive Membranes • Functionalized nanoparticles • Dendritic polymers Single enzyme nanoparticles Zeolites Nanoscale semiconductor photocatalysts Carbon nanotubes

Need to do a more general slide on risk, risk perception

Nano-Sized: Risk and Risk Perception "A key question to be answered is whether or not a particular nanoparticle has toxic or hazardous properties that are truly different from identical particles in their bulk form.“ Mark Wiesner, Duke University, Center for the Environmental Implications of NanoTechnology Nanotech Protection: Current Safety Equipment May Not Be Adequate (Oct. 16, 2009) — Canadian engineers suggest that research is needed into the risks associated with the growing field of nanotechnology manufacture so that appropriate protective equipment can be developed Carbon nanotubes: Scarring in mouse lung Carbon nanoparticles: no effect C&E News, Oct 27, 2009

Hot Nanotechnology Career Areas NSF: By 2015 we need 2 million nanotech-savvy workers

Colloidal Gold Experiment Objective Gain an understanding that nano size leads to changes in optical properties of materials Process Conduct Experiment Discuss & identify How it relates to topics that you teach Where this material can be inserted into your classroom

Mesogold How do I know there are gold particles there? Why is the color pinkish-purple? Mesosilver “The Blue Man” as seen on Today Show 21

Color Wheel Shows Complementary Colors 23

Nanospectra Biosciences, Inc. 24

Cancer Treatment ApplicationA Rifle Shot Cisplatin is a drug that treats cancer successfully. Unfortunately, the drug can harm healthy cells as well as cancerous ones. Nano gold particles combined with DNA deliver drugs directly to where they are needed inside a patient’s body. Once inside the cancer cells, cisplatin is then released, selectively killing the cancer cells.

Nano Size Experiments Objectives Demonstrate that nano size leads to changes in the way that a material interacts both physically and chemically Gain an understanding of surface area and size and how they play a role in physical and chemical reactions Process Conduct Experiments Discuss & identify How they relate to topics that you teach Where this material can be inserted into your classroom

Your Task Deliver two nanotechnology lessons to two classes 27

Nanotechnology for Middle/High School Teachers • A three-credit graduate course that serves as an introduction to nanotechnology, a field that is redefining the scientific landscape and will shape the future scientific careers of students • One third of the course is on-line nanotechnology content • Two-thirds is focused on the experiments and development of lesson plans that the individual teacher will deliver to students in the fall following the course 28

James K. Murray, Jr., PhD, Associate Professor & Chair, Chemistry Department, Immaculata University Barry F. Stein,