Nucleotide Substitutions (x100)

1. A-Chicken-CT-9407-03 A-Chicken-NY-116124-03 A-Turkey-VA-158512-02 A-Turkey-NC-11165-02 A-Chicken-VA-32-02 A-Turkey-VA-67-02 A-Turkey-VA-55-02 A-Chicken-PA-143586-01 A-Chicken-PA-143586-02 A-GuineaFowl-MA-148081-11-02 A-Avian-NY-74211-5-01 A-Chicken-NY-119256-7-01 A-Avian-NY-118353-1-01 A-Chicken-NJ-118878-5-01 A-Chicken-NJ-118555-2-01 A-Avian-NY-81746-5-00 A-Avian-NY-76247-3-00 A-Chicken-NY-30749-3-00 A-Pheasant-NJ-30739-9-00 A-Chicken-NJ-151244-18-02 A-Avian-NY-149717-12-02 A-Chicken-NJ-608-02 A-Chicken-NY-119055-7-01 A-Chicken-NJ-150383-7-02 A-Chicken-PA-149092-1-02 A-Chicken-BC-04 A-Chicken-BC-GSC-04 A-GSC-Chicken-B-BC-04 A-GSC-Chicken-BC-04 A-Duck-NJ-117228-7-01 A-Mallard-Alb-22-01 A-Pintail-Alb-25-01 A-Duck-PA-143585-01 A-blue-winged teal-TX-2-01 3.7 2 0 Nucleotide Substitutions (x100) M gene phylogenetic tree for H7 North American isolates (amantadine-resistant variants are shown in red)

2. A-chicken-Korea-S16-03 A-Duck-Shantou-1881-00 A-Duck-Shantou-2143-00 A-Duck-Shantou-2144-00 A-Duck-Shantou-1796-00 A-Duck-Shantou-1042-00 A-Duck-Shantou-1043-00 A-guineafowl-HK-NT184-03 A-Wild-Duck-Shantou-4808-01 A-Duck-Shantou-2134-00 A-Quail-HK-SSP225-01 A-Quail-HK-YU415-02 A-Quail-HK-YU1495-00 A-chicken-Korea-S18-03 A-duck-Korea-S13-03 A-chicken-Korea-S4-03 A-silky-chicken-Korea-S3-03 A-chicken-Korea-S1-2003 A-dove-Korea-S14-03 A-chicken-Korea-S5-03 A-chicken-Korea-S12-03 A-chicken-Korea-S15-03 A-Duck-Shantou-1588-00 A-Duck-Shantou-2030-00 A-chicken-HK-NT366-03 A-chicken-HK-SSP418-03 A-chicken-HK-SF1-03 A-chicken-HK-FY23-03 A-chicken-HK-WF126-03 A-chicken-HK-YU427-03 A-Chicken-HK-NT471-02 A-chicken-HK-SSP101-03 A-pheasant-HK-WF54-03 A-chicken-HK-BD90-03 A-chicken-HK-CSW291-03 A-chicken-HK-CSW153-03 A-chicken-HK-CSW304-03 A-chicken-HK-WF120-03 A-Duck-Shantou-2102-00 A-Chicken-Guangdong-10-00 A-Duck-Shantou-830-00 A-chicken-HK-AP45-03 A-guineafowl-HK-NT101-03 A-pigeon-HK-WF53-03 A-chicken-HK-TP38-03 A-chicken-HK-NT142-03 A-Duck-Shantou-2088-01 A-Chicken-HK-WF208-01 A-Pigeon-HK-WF286-00 A-Chicken-Henan-62-00 A-Chicken-HK-FY313-00 A-Duck-Nanchang-40361-01 A-Duck-Shantou-1605-01 5.3 4 2 0 Nucleotide Substitutions (x100) M gene phylogenetic tree for H9 Asian isolates (amantadine-resistant variants are shown in red)

3. A-Chicken-Thailand-1-04 A-Chicken-Thailand-73-04 A-chicken-Ayutthaya-Thailand-CU-23-04 A-Chicken-Thailand-9.1-04 A-Duck-Thailand-71.1-04 A-chicken-NP-Thailand-CU-K2-04 A-Goose-Thailand-79-04 A-Quail-Thailand-57-04 A-bird-Thailand-3.1-04 A-Chicken-Viet Nam-33-04 A-Chicken-Viet Nam-39-04 A-Chicken-Viet Nam-35-04 A-Chicken-Viet Nam-37-04 A-Chicken-Viet Nam-38-04 A-Chicken-Viet Nam-36-04 A-quail-Vietnam-36-04 A-Chicken-Viet Nam-C57-04 A-chicken-Vietnam-C58-04 A-Duck-Viet Nam-11-04 A-Chicken-HK-YU250-03 A-Silky Chicken-HK-SSP7-03 A-egret-HK-757.2-03 A-goose-HK-739.2-02 A-Chicken-HK-3169.1-02 A-Chicken-HK-YU46-03 A-Pigeon-HK-WF32-03 A-Chicken-HK-WF27-03 A-Chicken-HK-NT47-03 A-black headed gull-HK-12.1-03 A-Chicken-HK-3176.3-02 A-Chicken-HK-FY157-03 A-Chicken-HK-SP171-03 A-G.H-HK-793.1-02 A-feral pigeon-HK-862.7-02 A-tree sparrow-HK-864-02 A-Silky Chicken-HK-YU17-03 A-duck-HK-821-02 A-grey heron-HK-861.1-02 A-Chicken-HK-SF131-03 A-Chicken-HK-SSP139-03 A-Chicken-HK-SSP141-03 A-Chicken-HK-SSP94-03 A-Chicken-HK-YU316-03 A-Silky Chicken-HK-YU238-03 A-Pheasant-HK-NT123-03 A-Chicken-HK-NT136-03 A-Chicken-HK-NT71-03 A-Chicken-HK-NT93-03 A-chicken-HK-YU777-02 A-Chicken-YN-374-04 A-Duck-YN-6255-03 A-Chicken-YN-115-04 A-Duck-YN-6445-03 A-chicken-Guangdong-191-04 A-chicken-Korea-ES-03 A-duck-Korea-ESD1-03 A-chicken-Oita-8-04 A-chicken-Yamaguchi-7-04 A-chicken-Kyoto-3-04 A-crow-Kyoto-53-04 A-crow-Osaka-102-04 A-Chicken-ST-4231-03 A-chicken-Hubei-327-04 A-chicken-Hubei-489-04 A-Chicken-HK-YU357-03 A-Silky Chicken-HK-YU364-03 A-Chicken-HK-YU324-03 A-Chicken-HK-AP111-03 A-chicken-Guangdong-178-04 A-duck-China-E319-2-03 A-Pheasant-ST-44-04 A-Chicken-Indonesia-2A-03 A-Duck-Indonesia-MS-04 A-Chicken-Indonesia-5-04 A-Chicken-Indonesia-BL-03 A-Chicken-Indonesia-PA-03 A-Chicken-Indonesia-4-04 A-Chicken-HK-2133.1-03 A-duck-Guangdong-173-04 A-teal-China-2978.1-02 A-Duck-HN-101-04 A-Duck-HN-303-04 A-Duck-HN-5806-03 A-chicken-HK-61.9-02 A-Chicken-HK-YU22-02 A-Chicken-HK-WF157-03 A-peregrine falcon-HK-D0028-04 A-Duck-ST-4003-03 A-chicken-Guangdong-174-04 A-Chicken-HK-751.1-01 A-Goose-HK-76.1-01 A-Chicken-HK-829.2-01 A-Chicken-HK-FY77-01 A-Pheasant-HK-FY155-01 A-Chicken-HK-715.5-01 A-Chicken-HK-873.3-01 A-Duck-HK-573.4-01 A-Chicken-HK-YU562-01 A-Chicken-HK-YU563-01 A-Goose-HK-ww100-01 A-Duck-HK-2986.1-00 A-Duck-HK-380.5-01 A-Goose-HK-3014.8-00 A-chicken-HK-31.4-02 A-chicken-HK-409.1-02 A-chicken-HK-96.1-02 A-Duck-HK-646.3-01 A-Chicken-HK-FY150-01 A-Chicken-HK-31.2-02 A-Gf-HK-38-02 A-Silky Chicken-HK-YU100-02 A-pheasant-HK-sv674.15-02 A-duck-Shandong-093-04 A-Duck-Anyang-AVL-1-2001 A-Chicken-HK-866.3-01 A-Chicken-HK-SF219-01 A-Chicken-HK-830.2-01 A-Chicken-HK-858.3-01 A-Chicken-HK-893.2-01 A-Pigeon-HK-SF215-01 A-Chicken-HK-822.1-01 A-Chicken-HK-YU822.2-01 A-Silky Chicken-HK-SF189-01 A-Chicken-HK-876.1-01 A-Chicken-HK-879.1-01 A-Quail-HK-SF203-01 A-Chicken-HK-867.1-01 A-Chicken-HK-891.1-01 A-Goose-HK-ww26-00 A-Goose-HK-ww28-00 A-Goose-HK-ww491-00 A-Duck-HK-ww381-00 A-Duck-HK-ww461-00 A-Goose-HK-385.3-00 A-Goose-HK-385.5-00 A-Chicken-HK-317.5-01 A-chicken-Jilin-9-04 A-Chicken-HK-37.4-02 8.8 8 6 4 2 0 Nucleotide Substitutions (x100) M gene phylogenetic tree for H5 Asian isolates (amantadine-resistant variants are shown in red)