1 / 15

A Laser Afternoon: Introduction

A Laser Afternoon: Introduction. Ken Peach Particle Therapy Cancer Research Institute (Oxford Martin School) & John Adams Institute for Accelerator Science, University of Oxford Imperial College December 13 th 2012.

frayne
Download Presentation

A Laser Afternoon: Introduction

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. A Laser Afternoon:Introduction Ken Peach Particle Therapy Cancer Research Institute (Oxford Martin School) & John Adams Institute for Accelerator Science, University of Oxford Imperial College December 13th 2012 The tax mans taken all my dough,And left me in my stately home,Lazing on a sunny afternoon. Ray Davis (The Kinks) “Sunny Afternoon”

  2. Outline • What is needed? • Where could we help? • What should we do?

  3. Therapy Radiobiology What is needed?

  4. Depth Dose curves – photon and proton 100 tumour 80 SOBP Dose (%) 60 MV x-rays 40 Pristine peak 20 50 100 150 Depth (mm)

  5. Relative Biological Effectiveness (RBE) & Linear Energy Transfer (LET) • LET is related to dE/dx (Bethe Bloch) but is the energy transferred to the medium, not the energy lost by the particle

  6. RBE • The recommended value of RBE for protons is 1.1

  7. photon & proton irradiation • Averaged survival fractions over 3 repeated experiments. Dose (Gy) After AI Nagano (PTCRi, private communication) PTCRi Meeting

  8. Therapy Parameters: Energy 30 cm thickness of human body Radiography 300 MeV (p) 550 MeV/u (C)

  9. Summary of Therapy Requirements

  10. Summary of Radiobiology Desiderata • Energy reach • Protons, helium, lithium, carbon, oxygen • to at least 10-100 mm • 20-120 MeV (p) • 60-220 MeV/u (C) • Study mouse models in and away from the Bragg peak • Cell studies • Probably down to a few MeV/u • Flux • From single particle to >2 Gy/min • Field • Micro- or Nano-beam to 100 x 100 mm2

  11. Requirements for both • Desired energy • energy within 1% of specification • Small distribution of energy • s ~1% • Desired flux • High flux – 1% • Single particle • Precise transverse position • <0.5mm • ~microns (single particle)

  12. c.f. characteristics of a LEIR Radiobiology facility • Energy reach • Fully stripped 12C or 16O up to 240 MeV/u • 430 MeV/u (magnet limit) with new PS • Possible beam lines • Horizontal (full energy) • Vertical (limited energy ~100 MeV/u) • Large Hall • Currently used for storage • Space for radio biology laboratories • Status: under consideration • Feasability study in progress • Funding? • EU? Funding Agencies? Special budget?

  13. Where could we help?

  14. A Compact Laser-Plasma Ion Source • For radiobiology (see above) • Rapid change of ion species • “Small” footprint • (shielding!) • (few square metres) • Low(ish) cost • Not defined, but “less than millions” • For therapy • Use and an injector to a post-accelerator • FFAG-like (accelerate a spectrum) • Later (20-30) years? • Full therapy system

  15. Develop a simple plasma-driven ion source? reliable, reproducible, flexible, “cheap” Radiobiology easier than therapy as a first phase Therapy injector useful as a second phase Therapy eventually aim for a compact CPT facility Is there a possible funding source? Summary and conclusion

More Related