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Long-Term Excimer Laser Enhancements: Myopic PRK Following Myopic LASIK

Long-Term Excimer Laser Enhancements: Myopic PRK Following Myopic LASIK . Jonathan M. Davidorf, M.D. Davidorf Eye Group Los Angeles, CA ASCRS Annual Symposium San Diego, CA March , 2011. Financial Interest Disclosure.

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Long-Term Excimer Laser Enhancements: Myopic PRK Following Myopic LASIK

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  1. Long-Term Excimer Laser Enhancements: Myopic PRK Following Myopic LASIK Jonathan M. Davidorf, M.D. Davidorf Eye Group Los Angeles, CA ASCRS Annual Symposium San Diego, CA March, 2011

  2. Financial Interest Disclosure The author has no financial interest in any of the devices or techniques used in this study

  3. Purpose • To study the predictability and safety of myopic PRK in eyes previously treated with myopic LASIK.

  4. Background Three main options for performing laser vision enhancements following myopic lasik • Flap re-lift • flap re-cut • PRK

  5. Options for LASIK Enhancements

  6. Concerns About Epithelial Ingrowth The reported incidence of epithelial ingrowth ranges significantly in the literature1-5. Some authors have reported that there is a lower incidence of epithelial ingrowth in femtosecond laser created flaps compared to microkeratome created flaps3. At a minimum, patients with epithelial ingrowth need to be followed more closely (to identify progression) than non-epithelial ingrowth patients. The extra visits alone can become an inconvenience and source of concern for patients (even in the cases in which the epithelial ingrowth does not require intervention). If the epithelial ingrowth becomes significant (progression, visually significant, foreign body sensation), it must be treated, constituting additional, from the patient’s perspective, unanticipated inconvenience: office visits, procedures, risks.

  7. Concerns About Epithelial Ingrowth On the other hand, PRK is almost always inconvenient. Whether discussing the visual recovery or postoperative pain, there is little debate that uncomplicated LASIK (initial treatment or enhancement) provides, from the patient’s perspective, an easier postoperative process than uncomplicated PRK. However, the recovery with PRK is fairly predictable and easy to counsel. The surgeon and patient must decide between one procedure that carries with it the known downside of a slow recovery (PRK) and another that carries with it the somewhat difficult to predict complication of epithelial ingrowth. The incidence of epithelial ingrowth has been shown to rise when the initial LASIK procedure had been performed three or more years prior.2,5After reading recent such reports, we began using the three year mark as a guideline for recommending PRK to patients requesting enhancement of their initial LASIK procedure.

  8. Concerns about PRK following LASIK Apart from the visual recovery and postoperative pain, anticipated concerns of predictability arise when contemplating PRK following LASIK. For example, can epithelial hyperplasia impact the refractive outcome when the thickened area of epithelium is removed? In the case of prior myopic lasik, a hyperplastic central epithelial disk, if removed, could induce a hyperopic shift on its own, without any laser treatment being applied. Additionally, the risk of corneal haze always exists with PRK and has been reported to be an increased problem with post-LASIK eyes.6 However, intraoperative application of Mitomycin C may offset that risk somewhat.

  9. Methods • Ongoing prospective study Inclusion criteria: • eyes with a history of myopic LASIK performed more than three years prior • Eyes with myopia, with or without astigmatism

  10. Methods • PRK with EtOH epithelial debridement • B&L TechnolasExcimer Laser (PlanoScan software) • Post-laser 12 second application of 0.02% mitomycin C

  11. Demographics • 16 eyes of 15 patients • Mean follow-up 4.6 months (1 to 12 months) • Mean preoperative manifest refraction spherical equivalent: -1.37 + 0.69 D (-0.63 to -2.88 D) • Mean preoperative refractive cylinder:-0.78 + 0.55 D (-0.50 to -1.75 D)

  12. Results

  13. Uncorrected Visual Acuity at 1 Month

  14. Best Spectacle Corrected Vision • All eyes 20/20 or better pre- and postoperatively • No eyes lost or gained lines of BSCVA.

  15. Haze • No eyes developed visually significant corneal haze

  16. Predictability

  17. Predictability • 100% within 0.75D of target • 69% within 0.50D of target

  18. Discussion While firm conclusions cannot be drawn from this small series of treated eyes, the data suggests that PRK for low myopia and astigmatism is a predictable and safe means for treating eyes with a remote history of myopic LASIK. The refractive outcomes parallel the published data on myopic LASIK enhancements performed with flap re-lifting.1,4 Concerns of poor predictability owing to variable epithelial thicknesses, and safety concerns, including the possibility of corneal haze or disruption of the prior LASIK flap did not manifest as problems in this current series of eyes.

  19. Discussion Only one patient in this series had a bilateral treatment. Since this cohort comprised primarily patients with relatively low levels of refractive error, desiring treatment in only one eye, the patients would be expected to function reasonably well with the untreated eye while waiting for the treated eye to achieve good functional vision. With only one eye being treated, the recovery inconveniences of PRK are lessened compared to a bilateral simultaneous or bilateral sequential treatment. It is noteworthy that all of the treated eyes attained a good visual outcome by the one month visit.

  20. Conclusions In light of the published data on the incidence of epithelial ingrowth, combined with our encouraging preliminary data, we are continuing to recommend PRK for prior LASIK patients considering enhancement if their initial last LASIK procedure was performed over three years previously. Ultimately, longer term follow-up on a larger series of eyes is needed before firm guidelines and conclusions can be drawn.

  21. References • Brahma A, McGhee CNJ, Craig JP, Brown AD, Weed KH, McGhee J, Brown R. Safety and predictability of laser in situ keratomileusis enhancement by flap reelevation in high myopia. Journal of Cataract & Refractive Surgery . April 2001 (Vol. 27, Issue 4, Pages 593-603) • Caster A, Friess DW, Schwendeman FJ. Incidence of epithelial ingrowth in primary and retreatment laser in situ keratomileusis. Journal of Cataract & Refractive Surgery. January 2010 (Vol. 36, Issue 1, Pages 97-101) • HyunseokAhn H, Jin-Kook Kim, Chang Kook Kim, GyuHeon Han, KyoungYulSeo, EungKweon Kim, Tae-imKim. Comparison of laser in situ keratomileusis flaps created by 3 femtosecond lasers and a microkeratome. Journal of Cataract & Refractive Surgery. February 2011 (Vol. 37, Issue 2, Pages 349-357) • RubinfeldRS , Hardten DR, Donnenfeld EO, SteinRM, Koch DD, Speaker MG, Frucht-Pery, Kameen JA, Negvesky GJ. To lift or recut: Changing trends in LASIK enhancement . Journal of Cataract & Refractive Surgery . December 2003 (Vol. 29, Issue 12, Pages 2306-2317) • Waring , GO.; Durrie, DS.; Stahl, JE.; Schwendeman, FJ. Natural History of Epithelial Ingrowth After Lift Flap Enhancement Procedures for LASIK: Prospective Single-Center Evaluation. Abstract number 413055 presented at the American Society of Cataract and Refractive Surgery Annual Symposium, 2008. • Liu A, Manche EE. Visually significant haze after retreatment with photorefractive keratectomy with mitomycin-C following laser in situ keratomileusis . Journal of Cataract & Refractive Surgery . September 2010 (Vol. 36, Issue 9, Pages 1599-1601)

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