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Cutaneous ciliated cyst (Cutaneous Mullerian cyst)

Cutaneous ciliated cyst (Cutaneous Mullerian cyst). Deba P Sarma, MD Omaha. F 48, right heel. Cyst in the soft tissue. Note the cilia on the luminal border of the columnar epithelium. Pan-CK (CK AE 1/3): Positive cytoplasmic stain. Cam 5.2 (CK8/18): Positive cytoplasmic stain.

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Cutaneous ciliated cyst (Cutaneous Mullerian cyst)

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  1. Cutaneous ciliated cyst(Cutaneous Mullerian cyst) Deba P Sarma, MD Omaha

  2. F 48, right heel Cyst in the soft tissue

  3. Note the cilia on the luminal border of the columnar epithelium

  4. Pan-CK (CK AE 1/3): Positive cytoplasmic stain

  5. Cam 5.2 (CK8/18): Positive cytoplasmic stain

  6. CEA: Negative

  7. ER: Positive nuclear stain

  8. PR: Positve nuclear stain

  9. Diagnosis: Soft tissue, right heel, excisional biopsy: • Cutaneous ciliated cyst • (Cutaneous Mullerian cyst)

  10. Cutaneous ciliated cyst (Cutaneous Mullerian cyst) -Solitary cystic lesion of lower limb of woman (10-50 yrs). -Thought to be arising from heterotopic Mullerian epithelium. -Cyst is unilocular or multilocular with intralocular papillary projections, lined by ciliated cuboidal or columnar epithelium similar to that of fallopian tube. -Lining cells show immmunoprofile similar to that of fallopian tube epithelium (Positive cytoplasmic staining with CK, Negative CEA, and Positive nuclear staining with ER and PR). -Rare ciliated cutaneous cysts seen in man are thought to be arising from eccrine or apocrine gland with cilia metaplasia. -Differential diagnosis: Ciliated epithelial cells are also seen in brochogenic, thyroglossal duct, branchial, thymic and mature cystic Teratoma.

  11. REF: Stevens T, Sarma DP.(2011). Biopsy of a 5 mm cystic lesion on the right heel of a 48-year-old woman. Dermatol Online J. 15(17):6. PMID: 21696686. [PubMed – indexed for MEDLINE]

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