1 / 10

Michał Rachwalski

ENZYME-PROMOTED DESYMMETRISATIONS IN THE SYNTHESIS OF CHIRAL NON-RACEMIC ORGANOPHOSPHORUS COMPOUNDS. Michał Rachwalski Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Department of Heteroorganic Compounds, Sienkiewicza 112, 90-363 Łódź, Poland.

Download Presentation

Michał Rachwalski

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. ENZYME-PROMOTED DESYMMETRISATIONS IN THE SYNTHESIS OF CHIRAL NON-RACEMIC ORGANOPHOSPHORUS COMPOUNDS Michał Rachwalski Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Department of Heteroorganic Compounds, Sienkiewicza 112, 90-363 Łódź, Poland

  2. First example of desymmetrisation of prochiral phosphine oxides P. Kiełbasiński, R. Żurawiński, M. Albrycht, M. Mikołajczyk, Tetrahedron: Asymmetry 2003, 14, 3379

  3. Synthesis of prochiral bis(cyanomethyl)phenylphosphine oxide

  4. Possible products of hydrolysis of bis(cyanomethyl)phenylphosphine oxide

  5. Two crystallographically independent structures of monoamide 3

  6. Hydrolysis of bis(cyanomethyl)phenylphosphine oxide

  7. Synthesis of starting phosphine oxide

  8. Cyclic phosphorane racemic

  9. Attempts at enzymatic desymmetrisations of phosphine oxides

  10. Previous results

More Related