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lethals

lethals. genes which cause death of the organism. pleiotropy. Single gene affects many traits, even seemingly unrelated ones. epistasis. One non-allelic gene pair masks another -- from Greek, “standing upon” (much like dominance). collaboration.

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lethals

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  1. lethals • genes which cause death of the organism

  2. pleiotropy • Single gene affects many traits, even seemingly unrelated ones

  3. epistasis • One non-allelic gene pair masks another -- from Greek, “standing upon” (much like dominance)

  4. collaboration • Two non-allelie gene pairs produce novel phenotype (much like incomplete dominance)

  5. Polygenic traits • 2+ non-allelic gene pairs that control a single trait

  6. penetrance • % individuals who show phenotype expected from genotype

  7. expressivity • degree to which a particular gene is expressed in an individual

  8. Effects of the environment • environment affects gene expression • environmentally-produced phenotype which mimics genotype = phenocopy

  9. Linkage • Lack of independent assortment of genes due to location on the same chromosome

  10. Recombination • Breaks in linkage and transmission of new gene combinations on a single chromosome after prophase I crossovers

  11. Mapping • Using crossover frequencies as relative map units – allows construction of “maps” of gene locations

  12. Karyotype

  13. Causes of Genetic Diseases*aneuploidies from nondisjunctions

  14. Down’s syndrome

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