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Structural Correlates of Anesthetic Potency in Alkyl Alcohols

Structural Correlates of Anesthetic Potency in Alkyl Alcohols. James Sidie PhD Ursinus College. Eigenmannia virescens Transparent Knife Fish. WEAKLY ELECTRIC FISH CONTINUOUS EOD / PULSE EOD. ELECTRIC ORGAN DISCHARGE (EOD) Eigenmannia virescens.

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Structural Correlates of Anesthetic Potency in Alkyl Alcohols

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  1. Structural Correlates of Anesthetic Potency in Alkyl Alcohols James Sidie PhD Ursinus College

  2. Eigenmannia virescensTransparent Knife Fish

  3. WEAKLY ELECTRIC FISHCONTINUOUS EOD / PULSE EOD

  4. ELECTRIC ORGAN DISCHARGE (EOD)Eigenmannia virescens

  5. MEDULLARY PACEMAKER NUCLEUSEigenmannia virescens

  6. EXPERIMENTAL CONFIGURATION

  7. EFFECT OF CHAIN LENGTH ON EOD FREQUENCY - 50 ppm

  8. EFFECT OF CHAIN LENGTH ON EOD FREQUENCY - 25ppm

  9. CUBIC SPLINE ANALYSIS - FIRST FOUR MINUTES OF EXPOSURE TO ALCOHOL

  10. EFFECT OF CHAIN LENGTH ON EOD FREQUENCY - 12.5 ppm

  11. ANESTHETIC POTENCY OF UNSATURATED OCTANOLS

  12. MOLECULAR MODELLING OF UNSATURATED OCTANOLS

  13. EFFECT OF TEMPERATURE (25C/30C) ON OCTANOL EOD DEPRESSION

  14. EFFECT OF PKC INHIBITOR (CALBIOCHEM Go6983) ON OCTANOL

  15. CONCLUSIONS • ANESTHETIC POTENCY OF ALKYL ALCOHOLS AT 12.5/25/50 PPM IS POSITIVELY CORRELATED WITH CHAIN LENGTH UP TO 10 CARBONS • THE MORE TERMINAL THE POSITION OF THE -OH GROUP, THE GREATER THE POTENCY OF THE OCTANOL ISOMER • THE PRESENCE OF A DOUBLE BOND DECREASES ANESTHETIC POTENCY AS A FUNCTION OF BOND POSITION • PENTADECAFLUOROOCTANOL HAS NO ANESTHETIC EFFECT

  16. ACKNOWLEDGEMENTS DR. ERIC WILLIAMSEN DEPT. OF CHEMISTRY JUDY LYTLE ANGELO LEPORE BETH HOLLOWAY JENNIFER DERUYTER HHMI MERCK / AAAS

  17. MOLECULAR MODELLING OF 1,8 OCTANEDIOL

  18. TRENDS IN PHYSIOLOGICAL AND CONCENTRATION DATA

  19. GC CONCENTRATION MEASUREMENTS FOR GOLDFISH

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