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Chronic Eosinophilic Pneumonia

Chronic Eosinophilic Pneumonia. As Presented by Brett W. Baskovich …. What is it?. Pneumonia Eosinophilic Chronic. Causes of Eosinophilic Pneumonia. Churg -Strauss Syndrome Allergic Bronchopulmonary Aspergillosis Medications/Drugs/Toxins

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Chronic Eosinophilic Pneumonia

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  1. Chronic Eosinophilic Pneumonia As Presented by Brett W. Baskovich…

  2. What is it? • Pneumonia • Eosinophilic • Chronic

  3. Causes of Eosinophilic Pneumonia • Churg-Strauss Syndrome • Allergic BronchopulmonaryAspergillosis • Medications/Drugs/Toxins • Nitrofurantoin, ampicillin, ibuprofen, naproxen, phenytoin, sulfasalazine, tetracycline • Parasites- Löffler's syndrome

  4. Symptoms • Cough • Fever • Shortness of breath • Night sweats • Wheezing • Weight loss

  5. Diagnosis • Typically made 7 mo. after sx begin • Bronchoalveolarlavage

  6. Treatment • Option 1: Steroids

  7. Treatment • Prednisone 40 – 60 mg/day • Continue until Sx and CXR resolved (4-6 weeks) • Cut dose in half (8 weeks) • Reduce by 5 mg every 4 weeks

  8. Treatment • Maintain patient on minimum possible dose • Switch to alternate-day prednisone • Add inhaled corticosteroids

  9. Treatment • High-dose inhaled corticosteroid • Beclometasonedipropionate 1,600 mcg/day

  10. References • Chronic eosinophilic pneumonia complicated by bronchial asthma and diabetes mellitus successfully treated with suplatast tosilate and high-dose inhaled corticosteroid therapy. Fujimori K, Shimatsu Y et al. Nihon Kokyuki Gakkai Zasshi. 1999 Nov;37(11):903-8. • Chronic eosinophilic pneumonia: treatment with inhaled corticosteroids. Minakuchi M, Niimi A et al. Respiration. 2003 Jul-Aug;70(4):362-6. • Eosinophilic lung diseases: a clinical, radiologic, and pathologic overview. Jeong YJ, Kim KI et al. Radiographics. 2007 May-Jun;27(3):617-37; discussion 637-9. • Chronic eosinophilic pneumonia. Edwards LT, Fulmer JM et al. BUMC Proceedings. 1999;12:67-74. • Chronic eosinophilic pneumonia: a review. Alam M, Burki NK. South Med J. 2007 Jan;100(1):49-53.

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