One-pot total synthesis of K1 HGF domain

Oct 01, 2014

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S. S. a chain. b chain. Hepatocyte growth factor 90 kD. N. K1. K2. K3. K4. 85 Aa. 3 disulfide bridges. K1 weak MET Tyrosine kinase receptor agonist (Holmes, O. J. Mol. Biol. 2007 , 367 , 395) Part of HGF high affinity binding site. One-pot total synthesis of K1 HGF domain.

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chain
disulfide bonds
biologically active
met activation
3 disulfide bridges
hepatocyte growth factor

hagen

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One-pot total synthesis of K1 HGF domain

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S S a chain b chain Hepatocyte growth factor 90 kD N K1 K2 K3 K4 85 Aa 3 disulfide bridges K1 weak MET Tyrosine kinase receptor agonist(Holmes, O. J. Mol. Biol.2007, 367, 395) Part of HGF high affinity binding site One-pot total synthesis of K1 HGF domain • Disulfide bonds • Biologically active • MET activation, µM

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