ALSPAC: The future

1. ALSPAC: The future George Davey Smith, Scientific Director, Avon Longitudinal Study of Parents and Children 18 April 2012

2. “A Longitudinal Study of Pregnancy and Childhood (ALSPAC) is being planned by the University of Bristol and is due to start in 11 months’ time. The aim is to determine which biological, environmental, social, genetic, psychological, and psychosocial factors are associated with the survival and health of the fetus, infant and child. The cohort will consist of all births in the three Avon health districts over a 12- month period, and women and their partners will be recruited to the study as soon as possible after confirmation of pregnancy. Collaboration with other research groups or individuals is being sought. Potential collaborators should contact Dr Jean Golding, Division of Epidemiology, Institute of Child Health … Bristol.” Anon. (1989) Study on factors influencing child health. Lancet334: 518.

3. Pearson H. Children of the 90s: Coming of age. Nature 2012: 484: 155-158.

6. G0 Mother originally recruited to ALSPAC

7. G0 Mother originally recruited to ALSPAC Questionnaires passed on to ALSPAC mother’s partner

8. G0 Mother originally recruited to ALSPAC Questionnaires passed on to ALSPAC mother’s partner G1 Female ALSPAC YP Male ALSPAC YP

9. G0 Mother originally recruited to ALSPAC ALSPAC mother’s partner now being formally enrolled G1 Female ALSPAC YP Male ALSPAC YP

10. G0 Mother originally recruited to ALSPAC ALSPAC mother’s partner now being formally enrolled G1 Sibling of YP Sibling of YP Female ALSPAC YP Male ALSPAC YP

11. G0 Mother originally recruited to ALSPAC ALSPAC mother’s partner now being formally enrolled G1 Sibling of YP Sibling of YP Partner of YP Female ALSPAC YP Male ALSPAC YP Partner of YP

12. G0 Mother originally recruited to ALSPAC ALSPAC mother’s partner now being formally enrolled G1 Sibling of YP Sibling of YP Partner of YP Female ALSPAC YP Male ALSPAC YP Partner of YP G2 Offspring of ALSPAC YP Offspring of ALSPAC YP

13. COCO90s Planned data collection With thanks to Mel Lewcock and Debbie Lawlor

14. Some current activities • Record linkage, questionnaires and online data collection • Improving participation • The next generation • Fathers / partners clinic • Sibling recruitment • Recall by genotype / other recall • Collaborations – scaling up and scaling down • Increase access to and use of data

15. Integrating ‘Omics Technologies with Epidemiology Exposome • SNPs • CNVs • mtDNA variants • Rare variants • Whole genome sequencing • Data capture • Questionnaires • Environmental monitoring • Biological sample • analysis Genome Bioinformatics & Statistics Data integration Data mining Analysis methods Phenome • Questionnaires • Clinical assessment • Health records • Recall • Imaging • Educational • attainment • DNA methylation • miRNA expression • Chromatin analysis Epigenome Lifecourse Development To Ageing • LCL gene • expression • Tissue specific expression profiles • NMR metabolites • One carbon • intermediates Metabolome • Orbitrap-MS • intact protein • analysis Transcriptome Proteome

16. Metabolomics – measuring small molecules Kettunen et al. Nature Genetics 2012; 44(3):269-76

17. Making the most of multi-dimensional data- Integration and data mining

18. ALSPAC Publications as First or Last author

19. ALSPAC Publications 2006-2011

20. Pembrey M. Cohort of Genes. Nature 1990;348:280

21. Nature 12 April 2012; 484: 155-158

22. With thanks University of Bristol Medical Research Council/ Wellcome Trust National Institutes of Health ESRC European Research Council British Heart Foundation BBSRC EU FP7 Arthritis Research UK World Cancer Research Fund Autism Speaks 23andMe Diabetes UK ALSPAC: The future George Davey Smith, Scientific Director, Avon Longitudinal Study of Parents and Children 18 April 2012

23. With thanks With thanks Sarah Wordsworth Dara O’ Hare ALSPAC: The future George Davey Smith, Scientific Director, Avon Longitudinal Study of Parents and Children 18 April 2012