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HakF1R1D

100. HakF1R1D. 100. MasF1R1D. 86. XylF1R2A5. (An15g04140). (ACLA 087700). 0.1. (SS1G11404). 95. (An01g01130). XylF1R2A10. PyrF1R1A1. 57. PTRGlov3. OpiF1R2 D7. 63. (SS1G01792). HekF1R2A3. (An04g10030). 86. BfPKS1Cl1. 100. GraF1R1B. LecF1R1A2. MasF1R2B. 88. (MGG 12214).

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HakF1R1D

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  1. 100 HakF1R1D 100 MasF1R1D 86 XylF1R2A5 (An15g04140) (ACLA 087700) 0.1 (SS1G11404) 95 (An01g01130) XylF1R2A10 PyrF1R1A1 57 PTRGlov3 OpiF1R2 D7 63 (SS1G01792) HekF1R2A3 (An04g10030) 86 BfPKS1Cl1 100 GraF1R1B LecF1R1A2 MasF1R2B 88 (MGG 12214) GmPKS2Cl1 (MGG 08236) 91 ChPKS8Cl1 ChPKS5Cl1 100 (NFIA033590) 100 (AFUA 2G01290) 99 (ACLA 094600) (An03g05140) (SS1G02356) 52 99 (AO090001000506) 89 (AO090038000086) (An02g00450) 96 Opu2F1R1 D14 KagF1R1D HaoF1R1A ChPKS10Cl1 TryF1R1XLA 93 GmPKS5Cl1 93 95 PhoF1R2E 98 AcrF1R2A16 93 XylPKSMT (MGG 00806) 100 PTRGphe1 ChPKS9Cl1 98 AipF1R2A2 HekF1R1B1 LecF1R2A1 99 (ATEG 07279) Clade I (An11g05960) (ACLA 002670) 100 (ATEG 03446) EpiF1R2XA (SS1G03591) (MGG 00233) 50 PTRGphe2 93 LecF1R2B4 95 GzPKS4Cl1 (MGG 08285) (MGG 13767) 100 (PHN05791) 62 PTRGmyc1 100 (MGG 13596) PhoF1R1A An15g07920 91 (CHGG04475) 99 (AN2547.2) BfPKS11Cl4 PTRGfatty 94 (PHN12897) 100 AkpF1R1A8 96 (PODANg1131) 67 HinF1R2 76 (AN9217.2) (AN7838.2) 100 (An11g04280) (An12g02730) (CHGG03101) HinF1R1 8 100 GmPKS6Cl1 CogF1R2A1 83 XylPKSX1 (ACLA 098370) 100 (An11g05940) (ATEG 07282) PhaF1R1H (CHGG01021) MeaF1R1B1 91 HymdF1R1 J1 86 GmPKS7Cl1 97 CniF1R1A 97 PatF1R1XC (MGG 12613) 69 (CHGG09585) 77 (AO090701000826) SarF1R1B1 (AN6791.2) (AN2035.2) 67 89 (AN1036.2) 98 (ATEG 07379) D3 95 (CHGG07638) KagF1R1A 99 56 (CHGG05147) 58 (PODANg5999) 59 TryF1R1LA ChPKS3Cl1 50 (ACLA 063870) 100 (ATEG 09968) 68 AtlovFCl1 PcmlcBCl1 AcrF1R2A5 (PHN02561) 100 77 PTRGlov5 (ACLA 061310) 100 (NFIA002360) D4 90 (AFUA 3G01410) 87 (ACLA 063030) 100 (AO090009000052) 79 (ATEG 09088) 50 CopF1R1XA ChPKS7Cl1 LecF1R1B1 100 ChPKS1Cl1 DmPKS1Cl1 71 (An18g00520) 63 (AO090113000209) D2 (An11g00250) (ATEG 00282) (PODANg5890) 75 PhoF1R2B 54 (ATEG 00913) 80 HymdF1R2 J9 BebF1R2B3 XylF1R1A3 100 AstF1R1B1 (CHGG08147) 55 GmPKS13Cl4 100 OpiF1R1 J2 OpsF1R1 D15 100 (PHN11075) ChPKS14Cl4 (SS1G10474) LirF1R1B1 EpiF1R2A2 100 (NFIA062550) 100 (AFUA 3G14700) 66 (ACLA 043440) HaoF1R2D GraF1R1H (PHN13032) 100 60 (AFUA 1G01010) 60 (CHGG00087) TorF1R2A1 GmPKS12Cl4 TryF1R1F 64 (PODANg1326) (PODANg1601) (ATEG 06680) 69 78 (ACLA 055790) 74 (AO090010000402) HymF1R2D 69 HymF1R1B HymF1R1D OpsF1R1 D11 PyrF1R1B1 OpuF1R1A5 (NFIA057360) 90 (An12g02670) 53 Clade IV 97 (ATEG 09100) (AO090009000071) (AO090038000210) 68 (An09g01290) (AN9005.2) 100 (AFUA 3G02530) 90 (NFIA004080) (An09g05340) (AN6431.2) (AO090005000798) (An03g06380) KagF1R1E 97 53 85 KagF1R2E ChPKS15Cl4 (An07g01030) 57 (An01g06930) 97 ChPKS11Cl4 GmFUM1Cl4 (ATEG 08172) (AN8910.2) ChPKS12Cl4 (PHN14927) LatF1R1A1 100 Opu2F1R1 D2 OpuF1R1A3 OpiF1R2 D6 (AN3612.2) (PODANg7686) 100 68 AcrF1R2B1 CogF1R2B1 Fig. S1 (PHN09623) CogF1R1A1 (MGG 09645)

  2. 0.1 ConF1R1A1 100 NagF1R1A2 OpiF1R1 J7 100 OpmF1R1 D8 65 (PHN11272) 96 (SS1G09240) (PHN09490) 100 AipF1R2A5 74 OpuF1R2A2 Clade IV (MGG 10912) AknF1R2A GmPKS14Cl4 (AO090026000149) 54 (PODAN CAP65540) 100 NcPKS3Cl1 69 (ATEG 06056) 100 (CHGG10647) 100 (PODANg2799) (An15g05090) TryF1R1A GmPKS15Cl4 AkpF1R1B1 (An01g06950) 100 100 (NFIA093790) 80 (ATEG 01894) 97 (CHGG00246) 96 KagF1R2A 52 (PHN06676) 100 PepF1R1A1 93 ConF1R1A2 PhaF1R2I 100 (SS1G02211) 60 BfPKS10Cl4 BebF1R1A2 97 (PHN15965) 58 EpiF1R2B1 NagF1R1B1 (AN7084.2) 90 D1 LirF1R1B2 t GraF1R1C (NFIA023490) 100 (ATEG 04718) 100 MicF1R2D (AO090011000015) PyrF1R2A1 CopF1R2E (NFIA093910) (AFUA 8G00370) XylPKSKA1 ChPKS4Cl1 66 BebF1R2B2 63 IsjF1R1C4 100 MefF1R2B 100 PatF1R1C CopF1R1B8 60 HydF1R2A2 52 (An13g02430) (ATEG_07067) 95 HyrF1R1A 100 OpiF1R1_J12 62 OpsF1R2_D14 100 HymF1R1C 100 OpuF1R2A5 Opu2F1R2_D9 (CHGG00046) 100 NcPKS2Cl3 Clade III 72 (PODANg2301) (AO090020000186) (An12g07070) ChPKS2Cl3 100 ComF1R1B (MGG_12045) 94 100 HaoF1R1B 66 HakF1R1E 100 100 NagF1R2B1 92 PyrF1R2B1 XylF1R2A3 97 90 (CHGG08746) NcPKS1Cl3 100 53 BfPKS8Cl3 (SS1G01997) 86 (MGG_XP_362330) (PHN11065) (MGG_05589) D5 74 (PHN04868) 100 100 (PODANg1941) AstF1R2A1 99 (ATEG 03575) MeaF1R2A1 96 PTRGmyc2 AcrF1R1A12 KagF1R2Y (AN3610.2) D6 AcrF1R1B7 100 (SS1G01807) BfPKS2Cl1 (SS1G06923) GraF1R2B MasF1R1B LirF1R1A2 (SS1G07098) AknF1R1E 100 69 CopF1R1B1 98 GibF1R1B 100 (An13g02960) AstF1R1B2 IsjF1R2D3 100 CopF1R2F 100 (ACLA 077660) (An08g03790) ComF1R2C SarF1R2A2 (ACLA 055680) 100 TriF1R2 2 54 PTRGlov2 AtlovBCl2 100 PcmlcACl2 100 PepF1R2A1 93 ConF1R2B3 CobF1R2A4 (CHGG05286) (PHN00308) (ACLA 078660) (MGG XP 001412433) 100 (NFIA100520) 100 (AFUA 6G13930) (ACLA 042410) (AO090103000224) (An11g09720) (AN1784.2) (ATEG 09617) CopF1R2A1 (An04g04340) (AO090102000166) 100 (ACLA 098920) (AFUA 1G01280) 100 TriF1R1 7 63 CobF1R2A2 100 AcrF1R1B5 (SS1G13641) AstF1R2B2 (CHGG01239) Clade II MgAce1Cl2 95 (PHN07866) 100 PTRGlov4 53 ChPKS16Cl2 100 (PODANg1570) PatF1R2A HinF1R1 7 59 HaoF1R2C PTRGlov1 (PODANg2214) CeoF1R1A1 NagF1R2A1 LecF1R2B2 (MGG 12072) 100 (NFIA001530) 54 (AN8412.2) (AO090001000277) CniF1R1E 100 HydF1R1A2 AstF1R1A1 LatF1R2A1 100 CniF1R2A XylPKS3 (SS1G09237) 100 BfPKS6Cl2 81 HekF1R2B2 CogF1R1A4 91 (An02g08290) (An11g06460) BfPKS3Cl2 BfPKS4Cl2 MasF1R2A BbTenSCl2 TryF1R1B 91 71 AipF1R1A5 98 EpiF1R1A1 100 (CHGG04068) GmPKS8Cl2 100 GzFUS1Cl2 75 GmPKS10Cl2 ChPKS17Cl2 80 ConF1R1B3 HekF1R2A1 74 CogF1R2A3 89 (CHGG10092) (PODANg1178) 100 (AFUA 8G00540) 53 (ACLA 004770) (ATEG 00325) (PODANg09775) (MGCH7 ch7g16) 98 (CHGG05358) (ACLA 023380) GmPKS1Cl2 68 (CHGG02374) BfPKS5Cl2 FhEqiSCl2 GmPKS9Cl2 (AO090001000293) Fig. S1

  3. (NFIA101810) (AFUA 4G14560) (ATEG 08451) (NFIA101660) (AN8383.2) PTRGpig3 ChPKS19NB IsjF1R1C8 PTRGpig2 ChPK18NR2 (PHN11981) (ATEG 00145) (PHN08614) (MGG 00428) (PODANg8506) (AO090102000545) (An09g05130) AnwANR1 NFIAPKSP Afalb1NR1 (ACLA 076490) (AO090010000048) GmPKS4NR1 GzPK12NR1 (AO090005000961) (AN XP 681094) (PODANg7836) (AN7825.2) (MGG 07219) EnpkSTNR1 ClPKS1NR2 (PODANg8570) Nspks1NR2 AppkL1NR1 XylPK12NR2 (ATEG 06206) Glpks1NR2 GmPKS3NR1 (SS1G11789) (SS1G05681) BfPK12NR2 (PHN08274) (CHGG00542) (ATEG 07500) Mppks1C2 (PHN09932) (SS1G13322) BfPK13NR2 0.1 71 62 100 100 100 52 NR_I 100 100 100 50 56 96 68 54 82 100 100 91 96 100 53 NR_II 50 100 “NR” 100 96 51 96 100 90 100 100 50 (NFIA045430) 100 (AFUA 4G00210) 98 (ATEG 02434) 100 84 Atat5NR2 56 (AO090023000444) 97 (ACLA 043310) (PHN15828) 100 NR clade basal to clades I and II BfPKS14NB OpmF1R1J3 (NFIA112240) 100 (AFUA 7G00160) 100 (AN6000.2) 55 89 (An11g07310) 98 (AO090701000530) 87 100 (AN7071.2) ChPKS20NB (CHGG08141) 93 BfPKS15NB (AN7909.2) 58 69 (MGG 00241) PTRGpig1 Opu2F1R1 D8 82 PhaF1R1I (LACB244979) 63 90 (PODANg600) 99 96 PTRGpig4 OpmF1R1 J2 (AO090023000877) (ATEG 03432) (CHGG10027) (ACLA 008090) 52 BfPK17NR3 (AN0523.2) (ATEG 08662) 93 (AN3386.2) (NFIA003740) (ATEG 07661) 100 51 (AN1034.2) 100 98 (CHGG07645) (AN2032.2) 59 (AN3230.2) ChPK21NR3 51 (CHGG09586) NR_III (AFUA 3G02570) MGG 10011 (ATEG 03629) 97 (CHGG10128) 74 (AFUA 8G02350) 100 (NFIA096030) 76 (ACLA 61390) (AN6448.2) 65 (PODANg2680) BfPK18NR3 BfPK20NR3 (PHN07020) 100 50 ChPK23NR3 82 BfPK16NR3 91 PTRGMSAS 100 ChPK22NR3 (PHN06682) 78 (PODANg3829) (ATEG 10080) (CHGG08793) Pp6MSASPR 97 Bn6MSASPR Fungal MSASs 75 (ACLA 093660) 58 AtpksMPR 96 AppksL2PR 99 50 (PHN00477) ChPKS25PR XylPKS35PR MlPKSEBac 100 100 MtppsDBac Bacterial PKSs 52 MtppsCBac MtmasBac MamcyEBac (CHGG05113) 100 ChPKS24Hb Fig. S1

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