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FibroTest in the diagnosis of HBV

FibroTest in the diagnosis of HBV. Publications on diagnostic performance. In this Presentation. Diagnosis and clinical options. Positive serology. Poynard et al, Comp Hepatol 2004. First HBV validation. Myers RP et al, J Hepatol 2003 – First Validation in HBV.

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FibroTest in the diagnosis of HBV

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  1. FibroTest in the diagnosis of HBV Publications on diagnostic performance FT in diagnostic of HBV

  2. In this Presentation FT in diagnostic of HBV

  3. Diagnosis and clinical options Positive serology FT in diagnostic of HBV Poynard et al, Comp Hepatol 2004

  4. First HBV validation FT in diagnostic of HBV

  5. Myers RP et al, J Hepatol 2003 – First Validation in HBV • Prediction of liver histological lesions with biochemical markers in patients with chronic hepatitis B (n=209) FT in diagnostic of HBV

  6. FibroTest in Histological changes FT in diagnostic of HBV

  7. Poynard et al, Am J of hepatology 2005 Longitudinal Assessment of Histology Surrogate Markers (FibroTest–ActiTest) During Lamivudine Therapy in Patients with Chronic Hepatitis B Infection FT in diagnostic of HBV

  8. Kinetics of fibrosis according to baseline stages in HBV patients treated with lamivudine 2 years (n=283) FibroTest 0.73 1.00 0.52 0.75 0.50 0.25 0.00 Baseline 6 mo 12 mo 24 mo Poynard et al Am J G 2005 F2F3F4 P=0.01 F0F1 NS FT in diagnostic of HBV

  9. Poynard et al, AASLD 2007 Impact of adefovir dipivoxil on liver fibrosis and activity assessed with biochemical markers (FibroTest-ActiTest) in patients infected by Hepatitis B Virus FT in diagnostic of HBV Poynard et al, AASLD 2007

  10. Poynard et al, AASLD 2007 - Results • FibroTest and Fibrosis Stages FT in diagnostic of HBV

  11. Poynard et al, AASLD 2007 - Results • ActiTest and Necro-Inflammatory Features FT in diagnostic of HBV

  12. Poynard et al, AASLD 2007 - Results • ActiTest and Necro-Inflammatory Scoring System FT in diagnostic of HBV

  13. P<0.0001 Poynard et al, AASLD 2007 - Results • Impact of HBV treatment on fibrosis: Biopsy versus FibroTest 48 weeks with adefovir (n=304) or placebo (n=158) FibroTest Biopsy P<0.0001 FT in diagnostic of HBV

  14. P<0.0001 P=0.02 Poynard et al, AASLD 2007 - Results • Impact of HBV treatment on fibrosis in HBV Virological Responders with advanced baseline fibrosis 97 treated with adefovir, 9 treated with placebo (spontaneous clearance) FibroTest Biopsy P<0.0001 FT in diagnostic of HBV

  15. Poynard et al, AASLD 2007 - Conclusions FT in diagnostic of HBV

  16. Combination and comparison with other non invasive methods FibroScan, APRI, Mp3 FT in diagnostic of HBV

  17. Sebastiani et al, J Hepatol 2006 • Diagnostic performance of non-invasive biomarkers of liver fibrosis in chronic hepatitis B (n=110) >F2 F4 FT in diagnostic of HBV

  18. Sebastiani et al, J Hepatol 2006 – Safe Biopsy • Sequential Algorithms for Fibrosis Evaluation (SAFE BIOPSY)Stepwise modelling aimed to achive accuracy> 95% FT in diagnostic of HBV

  19. Sebastiani et al, J Hepatol 2006 – Safe Biopsy • Sequential Algorithms for Fibrosis Evaluation (SAFE BIOPSY)INTERIM ANALYSIS ON 210 HBV CASES FT in diagnostic of HBV

  20. Castera L. et al, J Hepatol 2006 • Prospective comparison in FibroScan (FS) and FibroTest (FT) in inactive hepatitis B carriers FT in diagnostic of HBV

  21. Hilleret et al, J Hepatol 2006 • Diagnostic accuracy of mp3 score compared to hyaluronate and FibroTest for evaluating liver fibrosis in chronic hepatitis B FT in diagnostic of HBV

  22. Meta analysis FT in diagnostic of HBV

  23. Poynard et al, clin chem 2007 FibroTest Meta-Analysis 30 Published Studies 6.378 Patients 2001-2006 AUROC=0.84 (0.83-0.86) for F2F3F4 The best you can obtain with 20mm biopsy is 0.90 Bedossa 2003 FT in diagnostic of HBV

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