Osteostrong

1. Osteostrong Osteoporosis RDA for Calcium Osteoporosis and menopause Product Supporting studies Reference

2. Osteoporosis • A disease characterized by low bone mass and structural deterioration of bone tissue leading to bone fragility and an increased susceptibility to fractures. 1993 Consensus Development Conference

3. The “silent disease” • Often called the “silent disease” • Bone loss occurs without symptoms • First sign may be a fracture due to weakened bones • A sudden strain or bump can break a bone

4. * Adequate Intake (AI)

5. Based on 2001 census,approximately 163 million Indians all the above age of 50,this is the expected case for Osteoporosis which will increase to 250 million by 2015(Department of Endocrinology and diabetes,New Delhi)

6. Studies • Major health threat for an estimated 44 million (55%) of people 50 years and older • 10 million estimated to have osteoporosis • 34 million have low bone mass placing them at risk • 1 in 2 women and 1 in 4 men over 50 will have an osteoporosis-related fracture Source: National Osteoporosis Foundation Web site; retrieved July 2005 at http://www.nof.org

7. The World Health Organization has established the following diagnostic guidelines

8. Hip fractures account for 300,000 hospitalizations annually. Source: The 2004 Surgeon General’s Report on Bone Health and Osteoporosishttp://www.surgeongeneral.gov/library/bonehealth

9. The most common breaks in weak bones are in the wrist, spine and hip.

10. Osteoporosisand menopauseare connected. • Osteoporosis occurs more rapidly in women than men particularly around the time of menopause when oestrogenand progesterone levels decline, effectively speeding up bone loss.

11. Following are risk factors for osteoporosis: • Women are at a greater risk than men • Women who are postmenopausal • Cigarette smoking, low amounts of calcium in the diet, heavy alcohol consumption, Inactive lifestyle. • Rheumatoid arthritis itself is a risk factor for osteoporosis. • Having a parent that has/had osteoporosis is a risk factor for the offspring.

12. Soft drink intake and Osteoporosis • The soft drinks contain high level of phosphoric acid and a high phosphate diet is associated with bone breakdown. • When phosphorus is excreted out it takes calcium out depriving the bones and the rest of the body with this important mineral. • More Salt in our diet can result in more Calcium loss from our bones making them fragile.

13. Vitamin D from sunlight exposure • Vitamin D is manufactured in your skin following direct exposure to sun. • Amount varies with time of day, season, latitude and skin pigmentation. • 10–15 minutes exposure of hands, arms and face 2–3 times/week may be sufficient (depending on skin sensitivity). • Clothing, sunscreen, window glass and pollution reduce amount produced. • Source: National Osteoporosis Foundation Web site; retrieved July 2005 at http://www.nof.org

14. Calcium supplement considerations

15. Calcium • Without Estrogen • is of • NO USE

16. How to Stay Healthy After Menopause? Osteostrong® OsteoStrong by Sami Direct is a health supplement for 40+ women who face an increased risk of declining bone density and fractures

17. OsteoStrong ® Loaded with natural ingredients like Calcium Citrate malate, Soy extract, Red Clover extract and BioPerine, OsteoStrong not only strengthens the bones from within but also helps prevent osteoporosis, and postmenopausal symptoms in women. • Soy extract + Red clover extract provide all 4 isofavones which together mimic the role of estrogen. • Estrogen without calcium is of no use • Calcium citrate malate is the best bioavailable form of Ca Thus OsteoStrong® is perfect in the management of osteoporosis.

18. Key benefits • Binds at estrogen receptors and prevents the body from over-producing estradiol. • Mimics the action of estrogen & along with most bio-available form of calcium, helps in Bone Mineral Density. • Boosts progesterone expression and helps to normalize the body’s important estrogen to progesterone ratio.

19. OsteoStrong ® Composition Each Tablet contains: Suggested use level: 1 tablet  2 times daily. * Patented - US & International Patents

20. Supporting Studies • Soy extract(40% Isoflavones) • Isoflavones are classified as phytoestrogens or plant derived estrogen. • These compounds are structurally similar to the female hormone estradiol. Isoflavones mimic estrogens by binding to estrogen receptors, affecting estrogen regulated processes and therefore referred to as phytoestrogen (plant estrogen) • Isoflavonesare important complementary estrogen and are useful and safe alternative to estrogen replacement therapy in postmenopausal women. • Isoflavones help in the preservation of the bones and fight osteoporosis. Inspite of their significantly weaker estrogen action, Isoflavones have powerful bone building effects (Ajmandi et al, 2001).

21. Supporting Studies • Red clover • Studies shows that isoflavones like found in red clover, will help reduce symptoms of menopause, such as hot flashes and night sweats, because of their estrogen like effects ( Baber et al,1999). • Several studies shows that proprietary extract of red clover Isoflavones suggest that it may significantly reduce hot flashes in menopausal women (Baber et al,1999). • Studies shows that a proprietary extract of red clover Isoflavones will slow down bone loss and even boost bone mineral density in pre and perimenopausal women (Occhiuto et al, 2007). • Calcium Citrate Malate • In 49 separate studies on bone mass and calcium, the data was in agreement that calcium supplementation was able to reduce bone loss at every site measured in post menopausal women except spine .The meta-analysis also concluded that calcium had a more beneficial effect in pre-and post menopausal women than in menopausal women (Heaney et al, 1996). • Studies shows that 1000mg daily calcium intake in premenopausal women could prevent the loss of one percent bone per year at all bone sites except the ulna (Welten et al, 1995).

22. References • Ajmandiet al,(2001) American college of Nutrition, vol 20,No.5 ,3985-4025. • Heaney et al, (1996).Nutrition and risk for osteoporosis ,San Diego ,CA: Academic Press INC.; 498-499. • Occhiuto et al, (2007)Effects of phytoestogenicIsoflavones from red clover on experimental osteoporosis, Feb;21 (2) : 130-4. • Welten et al,(1995).A meta-analysis of the effect of calcium on bone mass in young and middle aged female and males.JNutr 125 :2802-2813l

23. Thank you