Jiangsu Hengrui Medicine Co., Ltd 江苏恒瑞医药股份有限公司 2006 Better medicines to people ’ s health

1. Jiangsu Hengrui Medicine Co., Introduction Jiangsu Hengrui MedicineCo., Ltd 江苏恒瑞医药股份有限公司 2006 Better medicines to people’s health 关爱人类健康

2. Jiangsu Hengrui Medicine • Established: 1970 • Head Office: Lianyungang ,Jiangsu, China • President: Mr.Piaoyang Sun • Employees : 1800 • including: R&D 230 恒瑞医药始建于1970年，公司位于江苏连云港 董事长 孙飘扬 公司现有员工2000人，研发人员230人

3. Main Businesses Line Hengrui mainly produces antineoplastics, cardiovascular, analgesic, antibiotics . Hengrui was the No. 1 Antineoplastic sales in China Market in 2003、2004. 恒瑞主要从事抗肿瘤药、心血管类药、镇痛类药、 抗生素的生产。 2003、2004年抗肿瘤药销量全国排名第一。

4. Hengrui Group • Jiangsu Hengrui Medicine Co., Ltd. Pharmaceuticals and R&D • Shanghai Hengrui Medicine Co., Ltd. Pharmaceuticals and R&D

5. 连云港 ☉ 上海 成都 ☉ ☉ Shanghai Hengrui Medicine & Chengdu Hengrui Medicine

6. Workshop & Equipment Hengrui has two factory zones, the old one is located at Xinpu, the new one is located at ECO. & TECH Development Zone. 恒瑞现有两个厂区：新浦厂区 开发区新厂区

7. Workshop & Equipment The Xinpu factory is the main area of synthesizing and producing bulk drugs, including two solid preparation which passed to GMP inspection and 6 bulk drugs workshops. It can produce 20 kinds of chemical medicines 1.6 billion pills, 50 tons of 40 kinds of bulk drugs per year. 新浦厂区主要是固体制剂与原料药生产地，拥有2个通过 GMP认证的固体制剂车间、6个原料车间。 年生产能力为西药20种16亿片，化学原料药40种50吨。

8. Head office

9. Workshop & Equipment GMP固体制剂车间 Solid Preparation

10. Workshop & Equipment The new factory has an area of 30 thousand of square meters, which built preparation workshops according to GMP, and imported a batch of advanced equipment and production line. Now the factory is capable of producing 50 million injections, 2 million lyophilized powders and 2 million sterile split charging powder. 开发区新厂区占地3万多平方米，新建了符合GMP要求的制剂车间，并已引进了一批国外的先进设备仪器，新增年产针剂5000万支、冻干粉针200万瓶、灭菌分装粉针200万瓶的生产能力。

11. Capacity of Jiangsu Hengrui 50 million injections, 2 million lyophilized powders 2 million sterile split charging powder. 500 million troches 12 million transfusion bags

12. Freeze Dryer Imported from EDWARDS

13. Form-Fill-Seal Line

14. Solid Preparation Auto-Line

15. Auto-Packing Line

16. Subsidiary company－－Shanghai Hengrui ● 上海分公司2004年上半年建成投产。 Shanghai Hengrui was in production in Jun. 2004

17. Shanghai Hengrui Campus

18. Sales Net 恒瑞有九个销售公司，在全国各地有80个办事处， 共有1500名销售代表 Sale network covers all of the country. There are 62 sale offices inside China. Salespersons are over 1300. Active Pharmaceutical ingredients are mainly sold to USA and Europe.,

19. Jinagsu Hengrui Sales Status

20. Top 5 Products in 2004

21. FDA Approving ● 2001年恒瑞医药原料药异环磷酰胺、足叶乙甙、美司那、噻替派通过了美国FDA验证。 Ifosfamide, Etoposide, Mesna and Thiotepa were approved by FDA in 2001.

22. Export Status Of Raw Chemical Material Unit: ￥Tenthousand(RMB)

23. R &D Activity 研究与开发 恒瑞拥有2个研究中心 Hengrui Has Two R&D Centers • 恒瑞连云港研究中心 Lianyungang R&D Center 人员Researcher and Engineer：130 Persons 化学合成、植物药、中试研究、通用名药物 Chemical Synthesizing, Plant Drugs, Scale Test Before Production, Generic Medicines • 恒瑞上海研究中心 Shnaghai R&D Center 人员Researcher and Engineer：60 Persons 药物设计、化学合成、制剂研究、生物工程 Drug Design ,Chemical Synthesizing, Preparation Improvement, Biology Engineering

24. R & D Activity 研究 化学药物 Chemical Medicine: • COX-2抑制剂 Inhibitor BNP909 in Phase I BNP811 in Preclinical • 糖尿病PPARγ激动剂 Diabetes PPARγAgonist • 抗肿瘤药物 Antineoplastics • 胃动力药 Gastrokinetic agents • 抗生素 Antibiotics

25. R & D Activity 研究 植物药 Plant Drugs • 肝病治疗药Liver Treatment Drugs • 镇咳药 Antitussivers • 妇科用药 Gynecological Drugs 生物工程 Biology Engineering • 单克隆抗体 Monoclonal Antibody • 多肽合成 Polypeptide Synthesis

26. 合作研究 R&D Cooperation • 与美国Chiron公司合作研究 Cooperation Development with Chiron in USA : Eg5 • 与瑞典Medvir公司研究治疗 Cooperation with Medvir Co., in Sweden for Development of COPD Medicine

27. Thanks !