Spain’s Top 10 Companies Booming in Healthcare Sector 2022

1. June Issue 02 2022 Strength and Resilience Enhancing Inter-industry Coherence between different Aspects of the Healthcare Entities Novel Perspective How to Transform Present Healthcare Systems into Patient-Centric Wellness Ecosystem Oriol Segarra CEO Spain's Top 10 Companies Booming in Healthcare Sector 2022 Uriach Ushering an Era of Perpetual Innovations

4. Editor’s Note Transforming the Healthcare Horizons A s COVID-19 reached Europe, Spain became one of the worst-hit places early in 2020. This put lot of pressure on the three-layered, decentralized Spanish healthcare system. At one point in time, there were lots of concerns raised in the local as well as the global community about the scarce resources – from the local healthcare center's stockpile of medical equipment, number of frontline workers, doctors, and staff, to the number of hospitals, clinics and available beds. However, the major cause of community morale-boosting was due to the immediate response from the most prominent healthcare companies in Spain. These companies, faced with a severe healthcare crisis situation, rose to the occasion, stepped in immediately to tackle it, and used their agility, swiftness, expertise, strengths, and human-centric collaborative approach to significantly address all the problems, issues, and challenges from the front. From the rapid development of advanced digital technologies, including economical respiratory techs, to upgrading healthcare emergency communications

5. integration and response systems, these stalwarts left no stone unturned to digitally transform the healthcare system so that frontline workers, healthcare givers staff, doctors, nurses and especially patients could leverage the technological support efficiently and effectively. To comprehend their tremendous valuable efforts and grasp their extraordinary success, Insights Care has brought you a brand-new edition, 'Spain's Top 10 Companies Booming in Healthcare Sector 2022.' It also contains two trendy articles written by our in-house editorial team so that you can widen your perspective's horizon further. Dive in and Have a Delightful Read! The mission was spearheaded by Uriach, with its hundreds of collaborations across Spain, Italy, Portugal, Germany, Austria and Switzerland, its adaptability and development of cutting-edge products that highlight its commitment to society, and its successful evolution and transformation is based on five pillars: professionalism, strategic focus, growth and profitability, internationalization and, last but by no means least, a unique corporate culture focused on all of our collaborators. It was seconded by Asphalion, with its Regulatory and Scientific Consulting in Life Sciences since 2000, with several offices in Europe and a strong track record in projects involving Medical Writing, Pharmacovigilance, CMC, Regulatory Procedures, eSubmissions, Data Management, and Medical Devices. Anish Miller These two companies are followed by 24Genetics, DIVE- Medical, MOWOOT, Newborn Solutions, and more.

6. 24Genetics A Synonym of Excellence in DTC Genetic Testing 14 Asphalion Contributing to Ground-breaking Scientific Developments 20 DIVE-Medical Transforming Eye-tracking through Artificial Intelligence 24 MOWOOT 32 Novelties Ensuring the Quality of Life Newborn Solutions Novelties Flourishing the Infant Care 36 Onalabs Inno-Hub 41 Exhibiting New Generation of Medical Wearables Top Doctors Helping you Find Doctors at your Fingertip 48 WeFitter Connecting Users, Engaging Communities for a Healthy World 52

7. C O N T E N T S Cover Story 08 Uriach A Name Synonymous to Excellence Articles 44 28 Novel Perspective Strength and Resilience Enhancing Inter-industry Coherence between different Aspects of the Healthcare Entities How to Transform Present Healthcare Systems into Patient-Centric Wellness Ecosystem

8. Pooja Bansal Editor-in-Chief Anish Miller Senior Editor Abhishek Joshi Trishika, Gaurav Managing Editor Assisting Editors Visualiser David King Rohil Shinganapurkar Art & Design Head Co-designer Paul Belin Mrunalinee Deshmukh Art & Picture Editor Amy Jones John Smith Business Development Manager Marketing Manager Sarah Wilson, John Smith, Alex Vincent Kelli, Bill, Anna Business Development Executives Sales Executives Jacob Smile Amar Sawant Technical Head Assistant Technical Head David, Robert Technical Consultants Alina Sege Renuka Kulkarni Digital Marketing Manager Assistant Digital Marketing Manager SME-SMO Executives Atul, Gemson Eric Smith Research Analyst Tanaji Circulation Manager sales@insightscare.com June, 2022 Corporate Offices: Insights Success Media Tech LLC 555 Metro Place North, Suite 100, Dublin, OH 43017, United States Phone - 302-319-9947 Email: info@insightscare.com For Subscription: www.insightscare.com Insights Success Media and Technology Pvt. Ltd. Office No. 22, Rainbow Plaza, Shivar Chowk, Pimple Saudagar, Pune, Maharashtra 411017 Phone - India: 7410033802, 74100058552 Email: info@insightscare.com For Subscription: www.insightscare.com https://twitter.com/Insightscare Follow us on : www.facebook.com/InsightsCare/ Copyright © 2022 Insights Success Media and Technology Pvt. Ltd., All rights reserved. The content and images used in this magazine should not be reproduced or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission from Insights success. Reprint rights remain solely with Insights Success Media and Technology Pvt. Ltd. Insights Care is powered by Insights Success Media and Technology Pvt. Ltd.

9. Spain's Top 10 Companies Booming in Healthcare Sector 2022 Company Name Featuring Description 24Genetics is a biotechnology company specializing in Direct to Consumer Genetic tests. It has one of the broadest portfolios in the market with DNA tests for health prevention, pharmacogenomics, nutrigenetics, sports, ancestors, skincare, etc. Nacho Esteban, CEO 24Genetics Asphalion offers expert consulting, strategic advice, operational support and full outsourcing services for all drug development stages. Núria Romero, Managing Director Asphalion DIVE-Medical has developed a disruptive and novel technology whose impact on society is potentially immense and has achieved the recognition of important institutions, being its activity awarded with several prizes. Marta Ortin, CTO and Co-founder DIVE-Medical MOWOOT has been developed with the collaboration of Institut Guttmann, a reference hospital in Europe in the field of neurorehabilitation, its effectiveness has been clinically proven and has received numerous awards and recognitions. Dr Markus Wilhelms, CEO and Co-founder MoWoot Newborn Solutions develops non-invasive technology for detection and monitoring of infections in serous body fluids, with a main focus on infant meningitis, thanks to quick, easy and cost-effective solutions. Javier Jiménez, Founder and CEO New Born Solutions Onalabs Healthcare creates medical devices that make people's lives easier by monitoring their parameters without them noticing, without pain, without discomfort, wherever they are. Elisabet Del Valle, Co-founder and CEO Onalabs Healthcare TopDoctors® offers patients a trusted source of medical professionals, owing to the fact that it is the only medical website that selects its members according to medical excellence in the field. Alberto E. Porciani, President and CEO Top Doctors Uriach has a history dating back more than 180 years, and over a decade ago it decided to embark on a strategic transformation towards Natural Consumer Healthcare. Oriol Segarra, CEO Uriach Vytrus Biotech creates natural active ingredients for cosmetics on an industrial scale through innovative biotechnology processes which obtains the real power of plants. Albert Jané, CEO Vytrus Biotech WeFitter helps digital health platforms improve business performance, engagement and data insights introducing an aggregator API that provides connections with todays most used fitness app's, wearables and gamification elements. Nick Bosscher, Business Owner Wefitter

10. Cover Story Cover Story Ushering an Era of Perpetual Innovations Uriach has been registering double-digit growth for the past ten years, all thanks to its adaptability and development of cutting-edge products.

11. Oriol Segarra CEO

12. I a pivotal role in driving the organization's success to greater heights by achieving extraordinary results. n any industry, the organizations succeed when they build trust and create customer value with every interaction. Professionalism and a strategic focus play over 20 other countries on top of this. This means Uriach have brands that are already being sold in many European countries and which are therefore starting to go global. Uriach has been registering double-digit growth for the past ten years, thanks to its adaptability and development of cutting-edge products that highlight its commitment to society. Innovative pharmaceutical organizations that adopt a customer focus can gain an enormous advantage with new approaches to research and development, ensuring a robust portfolio of the perfect products are more likely to excel. This is where Uriach comes into the spotlight as one of the prominent companies in the health and pharmaceutical sector. The secret to Uriach's successful evolution and transformation is based on five pillars: professionalism, strategic focus, growth and profitability, internationalisation and, last but by no means least, a unique corporate culture focused on all of our collaborators being passionate about what they do and giving their all, so that we achieve extraordinary results time and time again. Uriach is guided by and focused on its mission and values—Unity, Resonance, Intensity, Ambition, Confidence, and History. These pillars help the organization be consistent and purposeful in everything it does. A Coherent Leadership Its purpose is clear: Uriach believes in the power of nature, enhanced by science, as the best way to improve human health and wellbeing, and the most sustainable too. Uriach wants to have a positive impact both on people´s life and the planet. Oriol Segarra joined Uriach in 2012. Counting with the trust of the shareholders and board members from day one, he built a fantastic team which has helped the organization enormously. As he led the company forwards in its transformation over the last few years: a transformation of which, as a team, Uriach is very proud of indeed. It has been an extraordinary Under the coherent leadership of its CEO, Oriol Segarra, Uriach has a great window of opportunity to become a European leader in the natural healthcare field over the next few years, combining its strengths with the clear market opportunity that is emerging to become globally relevant in this business segment. Setting Benchmarks Uriach's vision is to lead the way in the "Natural CHC" segment in Europe to be the most innovative company in this sector, with the best brands and the widest geographical footprint on its continent. Uriach's story began in 1838 and had five chapters, one for each generation of the Uriach family. Over the past 10 years, Uriach has been growing within the Consumer Healthcare sector (food supplements, over the counter healthcare products manufactured by means of private funds). And finally, in 2021, Uriach sold its B2B Pharma business to completely focus its activities on its Natural Consumer Healthcare sector, which manufactures highly innovative products based on scientific research and using natural ingredients. Today, Uriach has over 850 collaborators. Its subsidiaries in Spain, Italy, Portugal, Germany, Austria and Switzerland, the organization has a joint-venture agreement with local companies in Greece and Romania and sells its products in

13. Spain's Top 10 Companies Booming in Healthcare Sector 2022 journey during which Oriol and so many others in this great family have lived the best years of their professional life so far. Uriach's vision is to lead the way in the 'Natural CHC' segment in Europe to be the most innovative company in this sector, with the best brands and the widest geographical footprint on its continent. Uriach's revenue and EBITDA targets are to double its current levels through a combination of organic and inorganic growth. For Oriol, helping both people and the planet is extremely important on a personal and professional level. Uriach is experiencing a global trend in which consumers are viewing healthcare in a whole new light. They want the ways in which they care for their health to be holistic, sustainable and natural, with a greater focus on prevention. Enabling an era of Continual Novelties Uriach is a house of brands: brands are our main asset and, along with innovation, form the backbone of our business. Its mission is to build strong global brands (European for now), with the consumer at the heart of its strategy. Incorporating Exceptional Attributes Uriach wants to have a positive impact both on people's lives and on the planet. This is why its mission is to guide, facilitate and empower consumers in their transition towards a new, more natural way of improving their life, health and wellbeing, offering them the very best natural health solutions, empowering consumers and communicating with them through experts and prescribers on both a direct and indirect basis. Uriach's brands are positioned in several consumer categories and segments with different brand architectures. Still, all share the same DNA: the very best formulations and the most natural ingredients possible, all powered by science and innovation.

14. only because it has the best product portfolio (as proven by several awards over the last few years, such as "Premio Nutra Ingredients," "Product of the year" etc.), but also because of its innovative mindset. Uriach has set the target of increasing its direct presence in several new European markets. For Uriach, innovation is about new ways of being as well as new ways of doing. It is part of its culture; it is in the DNA of each and every one of Uriach's collaborators. Embracing the Future Roadmap Uriach has consolidated its strategic positioning in the Natural Consumer Healthcare segment and completed the professionalisation of the family business. In 2021, the Owners Council decided to nominate Luís Cantarell as President of the Board of Directors and as the first President external to the owner family. This process was initiated by the Uriach family in 2012 when the decision was taken to incorporate a new CEO external to the family for the day-to-day management of the business. Uriach has launched a new strategic plan for up to 2025, which outlines its vission to become the European leader in Natural CHC. Noteworthy brands in its portfolio include: Ÿ Aquilea (A leading Spanish brand of highly innovative food supplements focused on consumers and pharmacies). Ÿ Fisiocrem (Muscle preparation and recovery as well as joint pain treatment to take care of your physical wellbeing so you can live the lifestyle you want). One way in which Uriach will reach its goal is by increasing our direct presence on the continent. Its internationalisation process began in 2015 when the organization acquired the Italian company Laborest (followed by AR Fitofarma and Progine in 2019). Ÿ Laborest (A leading brand in Italy in the segment for highly sophisticated food supplements which are sold through medical consultations). In 2018, Uriach acquired Theralab in Portugal, and in 2021, it took over the German company Sidroga to secure its presence in the DACH region (Germany, Austria and Switzerland). In a nutshell, Uriach currently has a direct presence in eight of the main European markets through six subsidiaries and two joint-venture agreements (Greece and Romania). Aquilea, Fisiocrem and Laborest are already global brands, present in various European countries, with an annual turnover of over €50m. Uriach's portfolio of leading brands in its various local markets: Uriach has set the target of increasing its direct presence in several new European markets. One of its priority objectives is an expansion in France, the Nordic countries or several relevant markets in Eastern Europe. Bolstering its "Rest of the World (ROW)" business forms another key component of its international expansion plan. It refers to markets in which Uriach operates through strategic partners (currently more than 20). Ÿ Depuralina (leading weight-loss brand in Portugal) Ÿ Sidroga (leading medicinal tea brand in Germany and Switzerland), Ÿ and Biodramina, Aerored, Fave de Fuca, Halibut, etc., in Spain. Uriach never stops focusing on innovation. The organization wants to set the standards in its industry, not

15. However, it is important to highlight the fact that here at Uriach, making an active contribution to bringing about a better world is just as important as consolidating the business growth. This is why the sustainability plan and the global and local initiatives that have emerged from it have become a key pillar of our new strategic plan for 2022-25. Uriach has set the target of increasing its direct presence in several new European markets. We can only achieve all of this by constantly striving for creativity so that we remain unique in our industry and continuously improve how we connect with people. So that Uriach remains a company that dreams big and can make those dreams a reality. Recognition of Achievements Fisiocrem was scooped the Best Product for Athletes at the iDermo Awards in 2020, Colpofix was chosen as a winner in 'Excellence in Pharma: Finished Products' CPhI Awards 2020, among others. These awards are a “seal of quality” for the innovation they do at Uriach. With its exponential progress in the sector, Uriach has managed to change the lives of thousands of people with the quality and effectiveness of its natural products. Uriach wants to set the standards in the industry, not only because it has the best product portfolio but also because of its innovative mindset. “It shows that our products can sustain the evaluation of an international panel of scientific judges. It is a matter of pride for the whole team to win one of these highly coveted awards,”says the Innovation & Marketing Team. The company has been granted different awards: Fuca Regularidad has won a Nutraingredients award in 2022,

16. Nacho Esteban CEO 24Genetics'processes demonstrate that science and technology go hand in hand and adapt to the needs of consumers.

17. Spain's Top 10 Companies Booming in Healthcare Sector 2022 24Genetics A Synonym of Excellence in DTCGenetic Testing I has been made to unravel the underlying mechanisms of genetic disorders. Under the leadership of Nacho Esteban, CEO, the companyaims to help people make the best decisions related to their health by providing them with scientifically proven genetic information. n the last few years, genetics analysis has become crucial in clinical practice and research with the robust advancements in genomics technology. A great stride In an interview with Insights Care, Nacho Esteban shared valuable facts about 24Genetics highlighting the significance of its offerings—his opinions on the future of the company—in the healthcare industry. As genetic testing methods are becoming widely accessible and feasible to perform in a small-sized laboratory—conceding with advancements in computer technology—the application of genetic testing for personalized medicine is ushering in an era by providing new horizons for the betterment of human health. Comprehending this scenario, the developments in genetics and computer technologies continue to progress at their current speed—we can look forward to some fantastic results in human life in the near future. Nacho, enlighten our readers about 24Genetics, its vision its significant offerings in the healthcare niche. 24Genetics is one of the biggest Direct to Customer (DTC) European Biotechnology companies that currently operates in more than 100 countries and has thousands of clients. We have one of the widest range of DTC genetic tests in the world, which are considered to be the most comprehensive on the market. We have the recent innovation as genetic testing is commercially available; the individual now has the possible means to access this delicate information named Direct to Consumer (DTC) genetic testing. DTC provides an early awareness of genetic diseases and thereby offers individuals the opportunity to play an active role in the betterment of their own health care. With just one DNA kit, we offer seven reports: Ancestry, Health, Nutrigenetics, Skin Care, Talent and Personality, Sports, and Pharmacogenetics. Other companies can only see the ancestry in a few regions, but we do it in thousands; or show a handful of traits related to sports, nutrition, or skin, but we offer complete reports with hundreds of sections. And regarding process quality, our algorithms, developed by us and based on thousands of scientific papers, are among the most advanced available in the DTC DNA test market. Differing from the traditional hospital or physician-based testing, accessing an individual's genetic information without medical or specialized interpretation has gradually found a place in our daily lives. Today, a handful of companies from all over the world offer DTC services to the public. This is where 24Genetics excels in the limelight as one of the prominent providers of the widest range of DTC genetic tests in the world, which are the most comprehensive in the global healthcare industry. Our aim is to help people make the best decisions related to their health by providing them with scientifically proven genetic information. 24Genetics seeks to bring the valuable tools offered by genetics closer to people so that they can empower every person, through scientific and personalized genetic information, to make the best decisions for their health and well-being. Some of our main principles are… We do not sell our clients' genetic data and take your privacy to the extreme. Your sample becomes an Ÿ June 2022 15|www.insightscare.com

18. anonymous code when you take the test, and your report does not include your full name. Ÿ As a company, we believe it is only right to use the best technology available. In our case, we work with Illumina (world leader in genetic sequencing) and in a European laboratory to guarantee the highest quality. Ÿ With a single kit, you can have our seven reports. Today or whenever you want. And you do not need to send any other saliva sample. Ÿ We can send our kits to every country in the world. It does not matter where a person lives; we let him/her access to personalized and valuable genetic information. Ÿ What was your inspiration and commitment behind developing innovative healthcare products to improve people's lives? I have always been passionate about genetics, but the real inspiration was the severe illness that my mother suffered from, and from which she sadly passed away. That is what prompted me to try to materialize what I had always believed would be a breakthrough in the world of health. Now I am gradually convinced that 24Genetics is on the right way. Genetics can solve many problems if we bring it June 2022 16|www.insightscare.com

19. to the user level. Little by little, we are experiencing how it is becoming more relevant, and we want to contribute to that change happening as soon as possible. We want to expand the fields in which we operate so that in the future we can be a company that allows everyone to obtain the necessary information to be able to make the best decisions regarding their health. How does 24Genetics leverage the emerging trends of technology in the genetic report generation process? An example of this would be to have a central app in which a client could have all its information displayed and have it available for a health expert, providing the professional with the necessary information to give the patient the best treatment possible regardless of the capabilities of the hospital. The process we follow to generate our genetic reports: We extract the DNA from the saliva sample that clients send to us. Ÿ Please give us a few testimonials of your clients/customers and a list of awards/recognitions that accurately highlight 24Genetics position as a leading company in the market. (If available/permissible.) We transform the biological data contained in the DNA into computerized data. This process is called sequencing. Ÿ We apply the algorithms developed exclusively by 24Genetics to this computer data, which allows us to obtain each personalized report. Ÿ The reports are very precise and detailed; they explain everything. Very satisfied with all the service, commitment, and diligence. Thank you very much also for the assistance received with difficulties and questions. The package that they send you the kit with is detailed, impossible to miss and has genuinely nice packaging. You are informed step by step from the purchase to the receipt of the package to the reshipment and the various checks that are made. As you can see, we combine purely biological processes with in-computer processes, so that, without losing an ounce of scientific rigor, we can process huge amounts of information and provide detailed reports. Ÿ Clearly, our company's processes demonstrate that science and technology go hand in hand and adapt to the needs of consumers. Ÿ You do not feel abandoned, and you are informed of every step made to analyze the sample. I can say that the reports are precisely accurate. Some things, already confirmed with medical tests, have been reconfirmed with you, so I consider the rest very reliable. As an established industry leader, what would be your advice to the budding entrepreneurs and enthusiasts aspiring to venture into the healthcare industry? Obviously, I will do other checks as you recommended—an excellent product with great satisfaction. I highly recommend trying it. Try to find something that you really have a passion and interest in and are convinced that it is something that can contribute to improving the current healthcare landscape. Something that when you look back in a few years, you can be proud of the legacy you leave behind. - Giorgia A. Polleri from Trustpilot. Spectacular work of great professionals in the field. Results are explained in detail, with genetic divisions not only by communities but also by provinces and even counties, thus creating a precision that no other genetic study offers. 100% recommendable. What are your future goals, and how do you envision further strengthening the stronghold of 24Genetics in the healthcare sector? - Borja Pérez Gallo. June 2022 17|www.insightscare.com

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22. The values of upon its passion, commitment, companionship. Asphalion are built flexibility, quality, and

23. Asphalion development of business strategies and R&D activities required to develop and launch a successful product in the market. T offer reliability in the process. Consulting experts help organizations save precious time and money while building a reliable team of go-to experts under one roof. Life Science consultants and experts also help with the he Biotech industry is evolving at a rapid pace. As a result, Life Science consultants are increasingly in demand for SMBs to access specialist skills and Asphalion is a Regulatory and Scientific Consulting in Life Sciences founded in 2000, with several offices in Europe and that currently counts with an international team of more than 15 different nationalities. During all these years at Asphalion we have gained a strong track record in projects involving Medical Writing, Pharmacovigilance, CMC, Regulatory Procedures, eSubmissions, Data Management, and Medical Devices. We offer a full range of services in all drug development stages that span from pre-clinical and clinical to commercialisation and post-market. We have strong expertise in different types of products, including high complex ones such as Biologics and ATMPs. This expertise has also grown in terms of geographic scope. So far, we have 1,000 yearly ongoing projects and work for 500 clients from over 50 countries, and the number of markets where we operate keeps continuously increasing. Our experts have built strong personal relationships with regulatory agencies, associations, and key opinion leaders, particularly in Europe, the UK, and North America. Our global focus and our team's seniority allow us to implement the right solutions for each client, tailored specifically to their requirements, which allows us to often exceed our clients' expectations. Companies catering to the pharmaceutical industry have to undergo a rigorous regulatory process to bring a drug to the market—the meticulous research goes into every product, involving several skills from data analysis and statistics to drug development strategies and scientific writing. The art of giving advice is central to decision-making and often seen as passive consumption of wisdom. That's precisely the role Asphalion plays in helping the life science industry develop high-quality evidence in order to generate ideas while evolving the healthcare sector. The Managing Director of Asphalion Núria Romero envisions to be the global reference and driving force in the healthcare industry. Under her leadership—the organization offers a wide range of services—from drug development strategies and scientific writing to medicinal product management outsourcing. In an interview with Insights Care, Núria talks about how the organization provides a one-stop-shop to its clients in the process of drug development. Please give us a brief overview of your journey in the healthcare niche, highlighting the USPs of Asphalion. What makes Asphalion stand out is that we offer complete customer solutions: we are a one-stop-shop covering a full range of scientific and regulatory services in all drug development stages. Delve into her interview to get more insights on Asphalion. Núria, please tell us about Asphalion in detail. June 2022 21|www.insightscare.com

24. Our team is devoted to providing expertise, which is rooted in seniority and engagement; quality, as we are used to delivering results in complex situations, and we do have a high satisfaction rate from our clients; commitment, as we have a passionate and qualified team, willing and dedicated to every project and always up to date to latest standards; and flexibility, as we are constantly adapting to different requirements, and we are used to working with tight schedules. offering the best environment for the individual and collective growth of our team and clients. What is your opinion on the necessity for the healthcare industry to leverage the emerging trends of technology concerning fulfilling your client's requirements in the healthcare industry? Through our technology partners, we co-create solutions that bring added value from the point of view of digitalization and innovation, understanding that there is a need to find a combined effect between scientific and healthcare knowledge and technological and digital knowledge. What are the core values upon which Asphalion is built? What is its mission and vision? We want to be the preferred partner when it comes to scientific and regulatory affairs outsourcing: our quality and expertise are our core strengths and allow us to adapt ourselves to any request. For instance, Data Management and the tools that support it reflect the growing importance of automated services when dealing with the regulations. It is key to collect good quality information designed to improve data quality, and that allows companies, besides complying with the corresponding laws, to develop strategies and projects. Above all, it is necessary to have a skilled team to carry out this journey and a corporate mindset of the whole company focused on how to integrate technology in all solutions we offer to our clients, as well as to be continuously in the The values of our organization are built upon our passion, flexibility, commitment, quality, and companionship. Our team´s mission is our passion: Working together with our clients in order to generate ideas and implement solutions that contribute to improving health in all our lives. As for the vision, we dream about being a global reference and driving force in the evolution of the healthcare sector, June 2022 22|www.insightscare.com

25. search for innovation. Our clients benefit from our team´s knowledge and global focus. Still, they also benefit from our use of sophisticated project management tools that allow us to efficiently coordinate even the most complex international projects. What was your inspiration and commitment behind developing innovative healthcare products to improve people's lives? Our strategic objectives could be summarized by boosting our footprint in terms of growth and geographic scope. In addition to this, we see growth opportunities in innovative areas, such as biologicals, ATMPs, biosimilars, personalized medicines, and medical devices. According to our market research studies, we also expect an increasing demand for externalization in some specific well-established regulatory market segments and in pharmacovigilance. Bringing our knowledge in the regulatory field to any project and, as a result, making it possible for innovative solutions to reach patients sooner and better. These are not empty words: this is the purpose of our work, and we are very fortunate to be able to see it every day while solving our clients' challenges. Please give us a few testimonials of your clients/customers and a list of awards/recognitions that accurately highlight Asphalion's position as a booming company in the healthcare niche. "Thank you very much for helping us complete the submission on time, taking into account that we always send you the documents at the last minute. Your flexibility and dedication are always of great help in these critical moments," One of our main recent successes is our contribution to the development of more than 20 projects in the fight against COVID-19, which included: Regulatory support for the development of two vaccines against COVID-19; performance of pharmacovigilance activities for a COVID- 19 vaccine; Regulatory advice for a medical device's software for COVID-19 monitoring; Regulatory support for the preparation of Investigator's Brochure (IB) and IMPD for COVID-19 treatment and participation in the EU- funded Horizon COVID-19 project of ICFO (VASCOVID). We are proud to have collaborated on these projects, but prouder even of the high level of commitment and energy shown by Asphalion's team. As an established industry leader, what would be your advice to the budding entrepreneurs and enthusiasts aspiring to venture into the healthcare industry? I would tell them to get started as soon as possible! Learning by doing is key to having full competence and understanding of processes, being proactive, seeking out mentors who can orientate you, and, above all, being honest: honesty and integrity are the hallmarks of who we are and what we do. What are your future goals, and how do you envision further strengthening the stronghold of Asphalion in the healthcare sector? Thanks to the seniority of our team and its continued training, we have a clear vision of what the regulatory landscape will look like in the short and long term, so we can prepare ourselves and advise our clients to get ahead and overcome future challenges. - Head of Regulatory Affairs, European Biopharmaceutical Company. "Impeccable the way you have handled this issue with so little time. Spectacular attitude and technique. Thank you," - CEO, European Medical Devices Company. "I appreciate the fact of receiving multidisciplinary support in the regulatory and scientific field," - Regulatory Affairs Manager, European Pharmaceutical Company. "It has been my privilege and pleasure to work with many executives, and my experience with you has always been excellent. Couldn't ask for more!" - Pharmacovigilance Director, European Pharmaceutical Company. June 2022 23|www.insightscare.com

26. Our vision is to grow DIVE to become the national and international standard for exploring the visual function in all patients and become a reference in visual test development. Marta Ortin Chief Technology Officer, Co-founder June 2022 24|www.insightscare.com

27. Spain's Top 10 Companies Booming in Healthcare Sector 2022 DI E-Medical V Transforming Eye-tracking through Artificial Intelligence I challenge. The standard visual tests are majorly designed for adult patients with normal cognitive development. It is hardly possible to use the same tests in younger children or patients with developmental issues. n the current times, early detection of visual problems in infants, children below the age of three, and patients with neurocognitive disorder remain a significant From then on, several of the people who had worked in the research of the device within the institutions joined the company, in which we are already seven employees. Please give us a brief overview of your journey in the healthcare niche, highlighting the USPs of DIVE Medical. DIVE is a device that allows us to explore the visual function of any patient, even those with whom doctors cannot communicate (infants, young children, or people with neurocognitive problems) and who are more difficult to examine (such as patients with low vision). It is a great challenge for professionals to explore these patients, and the results they can obtain are often subjective and inaccurate. For this reason, the DIVE Medical Device has been developed to enable precise and objective exploration of the visual functions not only in children but in all non- collaborative patients. With a mission to provide universal, affordable, and effective means to prevent vision impairment, DIVE Medical's Chief Technology Officer and Co-founder, Marta Ortin, believes in the vision of ensuring early vision diagnosis and treatment. DIVE is able to perform a complete visual examination of these patients and provide objective and accurate measures of their visual function. In this way, we help make an earlier and more reliable diagnosis and facilitate the follow-up of pathologies and visual therapies. What are the core values upon which DIVE Medical is built? What is its vision and mission? Our vision is to grow DIVE to become the national and international standard for exploring the visual function in all patients and become a reference in visual test development. Our mission is to universalize eye care by offering new technologies that allow the early detection, diagnosis, and follow-up of visual pathologies in all types of patients. Our values are integrity, effectiveness, accountability, collective talent, and the pursuit of excellence. What is your opinion on the necessity for the healthcare industry to leverage the emerging trends of technology concerning fulfilling your client's requirements in the healthcare industry? In an interview with Insights Care, Marta talks about DIVE and how the device is helping doctors in the early diagnosis and treatment of visual problems in small children and babies. Below are the excerpts from the interview: Please tell us about DIVE Medical in detail. DIVE began as a collaborative research project between ophthalmologists and opticians from the Aragon Health Research Institute and engineers from the University of Zaragoza (Spain). When we presented our results at congresses, professionals in the field expressed a lot of interest in our project. They often told us that they would like to be able to use our device in their practice and that they thought it was something useful that could benefit many people. Encouraged by the good reception, we started this entrepreneurial adventure and found the company DIVE Medical in early 2020. June 2022 25|www.insightscare.com

28. Please give us a few testimonials of your clients/customers and a list of awards/recognitions that accurately highlight DIVE Medical's position as a booming company in the healthcare sector. The introduction of technology in the healthcare industry brings tremendous potential applications. In particular, in the ophthalmology field in which we work, without using technology, it is very challenging to explore certain patients (including babies, patients with neurocognitive disorders, or the elderly population), with results being very subjective and non-repeatable, and with some visual functions being impossible to measure. By introducing technology, these challenges can be overcome. In particular, DIVE has a screen on which we display stimuli designed to evaluate different aspects of the visual function. In addition, we incorporate eye-tracking technology, which allows us to know the point on the screen where the patient is looking at any given moment, and deep learning for an automatized analysis of the outcomes. What was your inspiration and commitment behind developing innovative healthcare products to improve people's lives? Testimonials from ophthalmologists with whom we ran a research project: "DIVE is a tool that puts technology at the service of clinical needs. It provides the ophthalmologist with very valuable information because it is capable of analyzing and quantifying visual functions as it had never been achieved before. It is especially useful for pediatric ophthalmology, where explorations can be difficult. DIVE captures children's attention from the beginning, and their collaboration is much better." - Teresa Pérez Roche. Pediatric Ophthalmologist. Hospital Universitario Miguel Servet, Zaragoza (Spain). "It is a very useful device for decision making. Experience and the subjective impression of the specialist are often needed to make a diagnosis. DIVE facilitates decision- making since it provides objective and quantitative data. It is also useful for patient follow-up, allowing to see their evolution and transmit the results. DIVE makes the office visits easier." We started working on this project to solve the need the ophthalmologists of our research team had every day during their clinical practice. As soon as we started working on the development of DIVE, we were able to see the impact of our work in a very close and immediate way. Our biggest motivation is DIVE's tangible beneficial impact on many patients; this is the most gratifying thing for us. As an established industry leader, what would be your advice to the budding entrepreneurs and enthusiasts aspiring to venture into the healthcare industry? - Sandra de Fernando. Ophthalmologist. Hospital Universitario Cruces, Bilbao (Spain). "Interesting device for a deeper analysis of ocular and saccadic movements. In children with neurological problems, it is [traditionally] more complicated to evaluate this function. Exploring contrast sensitivity and color perception is also very interesting for children whose diagnosis is more complex. Traditional tests are more boring, but through games [in DIVE] it is more enjoyable for children. Good experience with children that have syndromes or neurological problems. Useful for young children, with whom doubts arise when making a diagnosis." I would tell them to have a clear objective and high motivation. This is a complex sector that constitutes many paperwork requirements and a prolonged entry process. In turn, it is very rewarding to see how something you have worked on for years helps improve the lives of people. What are your future goals, and how do you envision further strengthening the stronghold of DIVE Medical in the healthcare sector? - Marta Galdós. Ophthalmologist. Hospital Universitario Cruces, Bilbao (Spain). We are currently focusing on applying our technology for visual exploration, but it has already opened up a lot of exciting opportunities. Besides incorporating new tests into our existing DIVE device, we are also planning on developing visual therapy exercises and systems for the automatic early detection of neurological pathologies that affect vision, such as Parkinson's, Alzheimer's, or autism. June 2022 26|www.insightscare.com

30. June 2022 28|www.insightscare.com

31. Strength and Resilience Enhancing Inter-industry Coherence between different Aspects Healthcare Ent?ies A structure that is accessible to everyone involved in the delivery of health services while complying with medical information, security, and privacy regulations, is part of delivering high-quality healthcare. Improving access to patient data effectively improves care quality and, as a result, patient satisfaction. As a result, using a CRM for hospitals and institutions has become a widely accepted innovation. of the ll healthcare providers strive to provide high- quality care to patients and consumers alike. Maintaining an organized, patient information Quality coordination for improved patient care Providing healthcare services is no longer a one-person job; multiple parties are now involved. The most difficult June 2022 29|www.insightscare.com

32. Use across an enterprise challenge, as with any setup involving multiple team members, is information access and synchronized planning. In a healthcare facility, a patient intake team usually refers the patient to the treatment team, who then refers the patient to post-treatment management and recovery. In order to provide the best possible care to the patient, such a setup relies on effective communication and information flow. Coordination is greatly improved with the use of CRM because all patients and healthcare personnel are centralized for easy access and management. A CRM system can connect data generated from consumer interactions across previously unconnected departments and functions, such as clinical delivery and care management, service operations, provider network management, and marketing. This previously disjointed data, now brought together by CRM systems, enables tailored and improved customer and provider engagement opportunities — getting the right data to the right people for desired results. Dynamic Healthcare Delivery An omnichannel approach Different departments within a hospital frequently collaborate to optimize patient care and make critical patient decisions. CRM makes it simple to establish cross- departmental collaborative care delivery. It is even possible to share data for patients who must switch between the public and private sectors. Allowing people to choose how they want to engage fosters loyalty and positive, connected relationships. CRM allows for the orchestration of communication and connected interaction across channels such as email, phone calls, texts, videos, virtual messaging, and more, allowing consumers to engage based on their preferences and convenience. Organizations see positive results by approaching customers through the channels they prefer. As a result, we now account for nearly 40% of all global customer service applications. Performance Analysis CRM in healthcare offers a unique opportunity to analyze and optimize day-to-day routine service delivery processes. CRM enables the collection of critical hospital dates such as admissions, discharges, transfers, referrals, and so on. Certain measures can be taken to enhance patient experiences by analyzing this data. Some unnecessary steps between admissions and referrals, for example, could be eliminated, and automated activities between disciplines could be tailored for maximum efficiency. Patients, too, recognize the importance of a positive healthcare experience. According to one study, more than 52% of patients prefer hospitals where they believe they will receive good customer service. Collection of all data – clinical and consumer A CRM system should combine consumer engagement data and social determinant information with a consumer's longitudinal health record to maximize value. A longitudinal record is made up of disparate sources, such as electronic health records (EHRs), claims, pharmacy, and self-reported data, that are organized into a coherent view for each individual. This clinically informed CRM serves as the foundation for providing the care team (including the consumer) with a complete picture of a person's health and well-being, status, or if alternative care options are available. Management of chronically ill patients The bottom line Patients with chronic illnesses require organized care, such as scheduled follow-up checkups and routine tests. It is possible to use CRM in healthcare not only to build relationships between the patient and the caregiving team but also to provide effective engagements within the caregiving team itself. Management plans can be easily tailored to the availability of the personnel involved, and follow-up checkups can be scheduled at the convenience of all parties involved, including the patient. Above all, treatment can be easily adapted and developed for specific patients, allowing for personalized care for each patient. According to some estimates, the CRM industry in healthcare will grow at a CAGR of around 9%. CRM in healthcare improves efficiencies through automated workflows across multiple parties and increases effective patient outreach. Coordination is effectively improved, allowing for cost-effectiveness without compromising the quality of care provided to patients. The implementation of CRM all across the healthcare system will not only improve the quality of care provided but also enhance inter-industry coherence between different aspects of the healthcare entities. June 2022 30|www.insightscare.com

34. Dr Markus Wilhelms CEO and Co-founder MOWOOT Novelties Ensuring the Quality of Life June 2022 32|www.insightscare.com

35. Spain's Top 10 Companies Booming in Healthcare Sector 2022 T working hand-in-hand with technology, and healthcare workers have to embrace emerging healthcare technologies to stay relevant in the coming years. What are the core values upon which MOWOOT is built, and What is its vision and mission? he future of healthcare is shaping up in front of our very eyes with advances in digital healthcare technology and nanotechnology. This rests in Since the beginning, the MOWOOT team has been guided by direct contact with patients and caregivers to develop and market our solution to solve an unmet need and improve the quality of life in patients with intestinal transit disorders. In medicine and healthcare, digital technology could help transform unsustainable healthcare systems into sustainable ones, equalize the relationship between medical professionals and patients, and provide cheaper, faster, more effective solutions for diseases. Technologies could simply lead to healthier individuals living in healthier communities. What is your opinion on the necessity for the healthcare industry to leverage the emerging trends of technology to fulfil your client's requirements in the healthcare industry? Firstly, I'd state understanding the unmet need, including all relevant stakeholders, and finding the simplest possible solution is crucial. Simplicity is elegance. Innovation does not necessarily need to be complicated. However, if a simple and elegant approach includes an 'emerging trend,' then go for it. Leveraging the latest advancements, MOWOOT,a growth- stage medical device company has developed a medical devicethat stimulates the large intestine in a non-invasive way. It is also marketing a novel, purely physical, non-drug, and non-invasive solution to chronic intestinal transit disorders, such as neurogenic bowel disorders (NBD), opioid-induced constipation (OIC) or chronic idiopathic constipation (CIC). What was your inspiration and commitment behind developing innovative healthcare products to improve people's lives? Under the proficient leadership of Dr Markus Wilhelms, CEO and Co-founder, MOWOOT has received the 'FDA Breakthrough Device Designation' for the critical impact on patients' quality of life, which opens the door to the large US market. Our founder team consists of four people with different professional backgrounds. What we have in common is that we want to have a positive impact on the patients and also on society. In an interview with Insights Care, Dr Markus Wilhelms sheds light on the innovations empowered by MOWOOT in the healthcare industry. Dr Wilhelms, please tell us about MOWOOT, its USPs and what makes it a successful company in the healthcare sector. MOWOOT team has been guided by direct contact with patients and caregivers to develop and market our solution to solve an unmet need and improve the quality of life in patients with intestinal transit disorders. The multidisciplinary founder team of MOWOOT met in 2013 in the dHealth Barcelona program for 'needs-driven innovation,' a European version of Stanford University's Biodesign program. Applying innovation methodologies like design-thinking and based on over 500 patient interviews, the team developed a solution to a significant unmet need in bowel management in collaboration with leading neuro- rehabilitation hospital Institut Guttmann and constituted the company in November 2014. The MOWOOT device is now already available in several European markets and is even recommended in various clinical guidelines. June 2022 33|www.insightscare.com

36. Please give us a list of awards/recognitions that accurately highlight your organization's position in the market. Among 23 companies, in an extraordinary all-digital Redefining Early-Stage Investments -RESI- conference edition, MOWOOT was voted as the 'Best Medical Device Company' of the event and achieved second place in the overall rating of the most voted company. MOWOOT received the seal of approval "Impact Business" for start-ups with social impact after a thorough analysis by the Ship2B foundation in the framework of their Tech4Health acceleration program. We firmly believe that to do so, to really reach as many people as possible, you not only need to have an innovative product but also implement it into a viable business model. Innovating in healthcare is one of the most difficult types of entrepreneurship, but we accepted the challenge! MOWOOT is the winner of the Best Overall Company st Award (1 place) as the company with the most votes of all three categories (MedTech, biotech and digital health) of the European Health Catapult at the EIT Health Summit in London. As an established industry leader, what would be your advice to the budding entrepreneurs and enthusiasts aspiring to venture into the healthcare industry? European Health Catapult is an acceleration program and start-up competition. It awards the best-of-the-best innovation concepts from MedTech, biotech, and digital health across Europe.MOWOOT is the winner of the st Audience Award (1 place) in the MedTech category of the European Health Catapult at the EIT Health Summit in London. First, start with understanding the unmet need and its environment/stakeholders and do lots of interviews to learn about this. You will have to develop a quantifiable value proposition for your solution, taking all stakeholders' needs into account (including payors, regulators, etc.) Apply the "scientific method" to business creation: build > measure > learn (repeat) MOWOOT also achieved second place in the Healthcare Professional Jury awards in the MedTech category of the European Health Catapult at the EIT Health Summit in London. Nowadays, there are very well-developed tools available to guide novice entrepreneurs in their healthcare adventure, for example, the GAITS system by CIMIT in Boston. I wish we would have had access to this type of tool when we started—highly recommended! What are your future goals, and how do you envision further strengthening the stronghold of MOWOOT in the healthcare sector? We plan to enter the public healthcare reimbursement in several EU markets regarding business development. Moreover, market entry in the USA is the next natural step for MOWOOT. Regarding products, we are working on a pediatric version of our device to answer a market pulled by many parents and caregivers who contacted us. June 2022 34|www.insightscare.com

38. Javier Jiménez Founder and CEO We strongly believe that innovation in medical technologies improves patient care and healthcare sustainability, and our goal is to create a social impact on people's health globally. Newborn Solutions Novelties Flourishing the Infant Care June 2022 36|www.insightscare.com

39. Spain's Top 10 Companies Booming in Healthcare Sector 2022 R industry being no exception. Advances in analytical techniques, integrated with the record of data in the healthcare organizations, bring about many potential use cases of AI in the fields of medicine and healthcare. apid advancements in Artificial Intelligence (AI) continue to introduce the technology to a wide range of industrial applications—the medical Newborn Solutions is a medical device startup that enables non-invasive screening and monitoring of infections in serous body fluids, with an initial and primary focus on infant meningitis. Meningitis suspicion is challenging due to the unspecific signs associated with the infection, such as fever of unknown source, particularly in infants and newborns with very little symptomatology. The role of AI also expands in the early detection of severe diseases enabling appropriate treatments and better outcomes for healthy living. This semblance shares the expertise and performance of specialist providers who tend to lack the precise fundamentals behind improving treatment outcomes. That's why history and physical examination alone are often insufficient to confirm or exclude the diagnosis. Lumbar puncture to draw a sample of cerebrospinal fluid is an essential investigation and the current standard; however, it is difficult to perform and potentially hazardous for the sick child. Neosonics, the medical device we developed, will be used to accurately rule out or confirm meningitis in a quick, easy and cost-effective way. Moreover, AI also assists in identifying the severities in infants, including infant meningitis and based on the identification of the infection; healthcare professionals can diagnose the problem and provide prompt medical treatments. Early diagnosis and treatment are crucial for a positive outcome, yet identifying meningitis is a complex process involving an array of signs, symptoms and multiple causal factors which require novel solutions to support clinical decision-making. Neosonics is a first-in-class medical device that uses high- resolution ultrasound, unique coupling materials, and Artificial Intelligence algorithms to automatically count, at the push of a button, white blood cells in the cerebrospinal fluid directly below the infant fontanelle, a well-established diagnostic marker for infections. We also work on our software-based development named Neosonics-AI. AI gives us the automatization, the speed, and the accuracy. And when combing the non-invasive cell concentration measurement with Big Data, AI also has the potential to empower the user (expert and non-expert) with diagnostic information of the likely causing organisms so that the precise treatment, dose, and duration can be applied anywhere. Newborn Solutions, a medical device start-up that enables non-invasive screening and monitoring of infections created—first-in-class—an investigational medical device (not for sale) that uses high-resolution ultrasound, unique coupling materials, and Artificial Intelligence algorithms—to accurately rule out or confirm meningitis in neonates and small infants in a quick, easy and cost- effective way. We are working on second-line applications, upon request from key opinion leaders. Notably, the device is being tested to show clinical feasibility in uveitis and peritonitis. We are thrilled to say that the start of the clinical trials is already very promising. Under the coherent leadership of Javier Jiménez, Founder and CEO, the company is setting up the new standard for screening and treatment monitoring and is revolutionizing the management and diagnosis of infant meningitis by enabling quick, easy detection, quantitative, reliable and frequent treatment monitoring. Please tell us about your journey highlighting the novelties of Newborn Solutions in the healthcare niche. In an interview with Insights Care, Javier Jiménez sheds light on the professional tenure showcasing the journey of Newborn Solutions and unveils its revolutionary medical device that is empowering innovations in the healthcare niche. I founded Newborn Solutions after my participation in the M+Visión program, an initiative of the Madri+d Foundation and the Massachusetts Institute of Technology (MIT) to leverage the biomedical industry in the Regional Government of Madrid. Madrid-MIT M+Visión researchers are selected from all over the world to form multinational and multicultural teams to generate technology-based ideas that solve unmet medical needs. The start-up was launched in 2015 with the desire to revolutionize the field of medical Javier, enlighten our readers about Newborn Solutions in detail. June 2022 37|www.insightscare.com

40. devices for non-invasive monitoring and screening of infant meningitis. and resource-constrained countries, and that is why we are using low-cost high-resolution ultrasound combined with AI for complete automatization and Big Data to enable accurate diagnosis and treatment. Our unique selling proposition is Neosonics, a quick, easy and cost-effective medical device to enable non-invasive screening and monitoring of serous fluids infections, with an initial focus on infant meningitis. In industrialized countries where the incidence of infant meningitis is relatively low, Neosonics will limit the use of lumbar punctures to only those very few positive cases (3-5%), thus, dramatically reducing the use of such an invasive procedure in most of the suspected patients. What is your opinion on the necessity for the healthcare industry to leverage the emerging trends of technology, concerning fulfilling your client's requirements in the healthcare industry? Clients have traditionally demanded more and more non- invasive solutions that help them take quick and accurate diagnostic solutions so that they can efficiently treat and provide better to their patients. In low-income settings where the burden of the disease is high but there is a lack of laboratory infrastructure and training, the device will help reduce misdiagnosis, mortality, and morbidity rates. The disruption of AI in healthcare together with the use of Big Data seems to offer unlimited and already untapped solutions to the healthcare professional and system. However, these technologies often require access to electronic patient data records and connect to remote servers. As a result, sensitive ethical and privacy concerns must be well addressed by regulatory bodies to enable the healthcare system to benefit from the advantages of these technologies. What are the core values upon which Newborn Solutions is built? What is its vision and mission? Our mission is to enable quick, easy, cost-effective screening and monitoring of infectious diseases in serous fluids through innovative non-invasive technology. We believe that the future of diagnostics must go through minimally invasive, quick, easy to use, and low-cost technologies. This is our vision from Newborn Solutions given our operations in developed countries and developing Without ethical and privacy concerns being properly regulated to protect the citizen and the healthcare system, clients (hospitals) should carefully consider the adoption of June 2022 38|www.insightscare.com

41. What are your future goals, and how do you envision further strengthening the stronghold of Newborn Solutions in the healthcare sector? such new products and if, in case of adopted, they can guarantee the rights of their patients will not be breached. What was your inspiration and commitment behind developing innovative healthcare products to improve people's lives? Neosonics, the device to non-invasively screen for infant meningitis, will be launched in late 2023 according to our plan. We will enter Spain first to show profitability and where we have invaluable KOLs with whom we are spreading a state of opinion about the project, and always with our support to the Spanish Meningitis Association. We strongly believe that innovation in medical technologies improves patient care and healthcare sustainability, and our goal is to create a social impact on people's health worldwide. This means that we need to work first on what the patient is really in need of and only then apply innovation to address that need. The USA is our next target market followed by a country with a high disease burden yet a lack of resources like India. If we show adoption in these regions, we will be proving the scalability of the business not only in infant meningitis but also in other second-line applications we are developing, like peritonitis or uveitis. As an established industry leader, what would be your advice to the budding entrepreneurs and enthusiasts aspiring to venture into the healthcare industry? While we have committed commercialization partners in Spain, we are looking forward to engaging with a strategic partner for global commercialization with whom we can maximize concerted efforts and the jointly delivered value as much as possible. We are not an established industry leader. If anything, we are a start-up trying to have a global meaningful impact in healthcare and in a way, we respect diversity and the environment as much as possible. My advice is to take one step after the other, having a clear long-term vision in mind, validate/test every decision before you take it, make the necessary steps to reflect on the big picture in case adjustments are needed and if you are not thinking about your project 18h a day, do not take any further step. June 2022 39|www.insightscare.com

43. Spain's Top 10 Companies Booming in Healthcare Sector 2022 Onalabs Inno-Hub Exhibi?ng New Genera?on of Medical Wearables M It is a general belief that the screening procedures are too complicated. Adding to the misery, people feel anxious and there is a negative emotion attached while undergoing a health test. But what if one does not have to go through screenings, and a single device can help detect abnormalities by monitoring your sweat. ost people know the importance of health screening, yet they avoid undergoing one. Why is it so? people and patients, minimizing costs of hospitalization, reducing the health system expenditure, and implementing smart, non-invasive, and continuous biomarker monitoring solutions. We have a complete long-term product roadmap with products devoted to vital health signs monitoring and critical metabolic biomarkers (such as lactate and glucose). Our product pipeline consists of devices: Well, that's precisely what OnalabsInno-Hub has to offer. Unfolding its exclusive and patented technology, Onalabs has presented the healthcare niche with a new generation of non-invasive, remote, and continuous healthcare monitoring. Having the right knowledge, technology and expertise has enabled the company to monitor people's health anytime, anywhere, without pain, and even without realizing it. That's what makes the company unique. Devices for chronic complex and fragile patients or home hospitalization Diabetic Patients Sports Health Ÿ Ÿ Ÿ Please give us a brief overview of your journey in the healthcare niche, highlighting OnalabsInno-Hub's USPs. Standing at the forefront of the company's massive think- tank Elisabet Del Valle, Co-founder and CEO, believes in leadingthe future of healthcare concerning inclusive, personalized, sustainable, and universal health. We have developed an exclusive and patented technology that converts sweat into an intelligent biofluid and skin in a health data platform during our five years of life. This technology is a mix of ultra-sensitive sensors, microfluidic designs, and complex algorithms. In an interview with Insights Care, Elisabet talks about Onalabs USPs and how it is offering solutions that positively impact the healthcare niche. Thanks to this technology, we are bringing to the market a new generation of medical-grade wearables that can send internal body data in real-time to the doctors. We could measure more than 200 metabolites and ions, 800 proteins, and 32.000 endogenous peptides through sweat. Below are the highlights: Please tell us about OnalabsInno-Hub in detail. Being able to read biomarkers in sweat, we are generating a new paradigm in non-invasive, remote, and continuous health monitoring. Onalabs is a bioengineering technological company involved in maximizing the well-being and life quality of June 2022 41|www.insightscare.com

44. By improving people's health, we will contribute to improving the world in which we live. Elisabet Del Valle Co-founder and CEO Onalabs is participating in the next healthcare revolution, creating a set of remote sensing devices where data is continuously processed and analysed. This aggregate data has the potential to be used for preventative medicine, real-time diagnostics, disease monitoring, and therapeutic delivery. Achievement: The future of healthcare will facilitate more timely and accurate interventions, improving outcomes for patients and the entire healthcare ecosystem. Data sources will include healthcare networks (hospitals, clinics, and laboratories), technology networks (sensors, monitoring, IoT devices), and social networks. For us, success is more about people enjoying a higher quality of life through our technology. To facilitate the monitoring of their main parameters through comfortable, innovative, and reliable devices. To be by their side so that they feel freer and improve their performance in sport. We are persevering because our dream is to make the dream of others come true. What are the core values upon which OnalabsInno-Hub is built? What is its vision and mission? Innovation: Vision: Research is part of our DNA. Our R&D team works to create avant-garde solutions that pose a before and after in the measurement during sport or in health management. We are disruptive; we have the knowledge, technology, and expertise to do it. To lead the future toward inclusive, personalized, sustainable, and universal health. Mission: Freedom: To create a new generation of non-invasive and smart medical-grade wearables to monitor people's health anytime, anywhere, without pain, without realizing it. We want to empower people, contribute to their freedom through intelligent solutions, focus on their real needs, and June 2022 42|www.insightscare.com

45. To help professionalsin their daily activities, improving prevention, diagnostic, treatment, and protocols. facilitate their daily care. Health begins with the knowledge of our own body, and our greatest encouragement is to achieve it in a non-invasive and rigorous way. Ÿ To reduce healthcare costs by reducing hospitalization and monitoring patients remotely. Ÿ Universalism: As an established industry leader, what would be your advice to the budding entrepreneurs and enthusiasts aspiring to venture into the healthcare industry? Health should be a universal right, and at Onalabs, we want to reach out to all people. To sportspeople, patients, and health professionals. We are plural, collaborative and global. Because by improving people's health, we will contribute to improving the world in which we live. Based on our experience, the best advice we can give to entrepreneurs is to focus on having the science behind the product or solutions well protected, knowing very well the real needs of the market, and having the enthusiasm and resilience to never stop pushing the project. What is your opinion on the necessity for the healthcare industry to leverage the emerging trends of technology, concerning to fulfil your client's requirements in the healthcare industry? What are your future goals, and how do you envision further strengthening the stronghold of OnalabsInno- Hub in the healthcare sector? Coronavirus has changed our daily life; it has accelerated the need to reduce the visits of risky chronic patients to the hospital, enhancing remote assistance. Moreover, there is an increased burden on healthcare systems due to the aging population and longer life expectancy. It is time to accelerate remote patient monitoring. Our upcoming activities are on the way to consolidating two of the most important goals for Onalabs. On the one hand, consolidate us in the European market, and begin negotiations to enter the North American market. On the other hand, continue strengthening our presence with strategic alliances with prominent key players to achieve an excellent position in a few years. There are a lot of IT platforms to visualize clinical data, and wearable technologies are leading the market to improve remote patient monitorization. However, real telemedicine is still far away from being a reality. Please give us a few testimonials of your clients/customers and a list of awards/recognitions that accurately highlight your organization's position in the market. One of the most important limitations is that current technologies are limited because blood samples are required to detect most of the current biomarkers (glucose, lactate, cortisol): a big barrier for remote and real-time monitoring and causing important problems. List of awards/recognitions: For that reason, Onalabs has developed a new generation of medical-grade wearables that has the ability to measure clinical reliability and accurate remote data of physical and biochemical biomarkers simultaneously. Seal of excellence by the European Commission Selected for Roche Start-up Day, the Only Spanish company selected among 150 international projects Selected for Allianz Startup Challenge in the Sport Tomorrow Congress of the Futbol Club Barcelona Winning Start-up of Andorra Government DRAC Prize in Innovation by RAC1 (one of the main radio stations in Spain) Ÿ Ÿ Ÿ What was your inspiration and commitment behind developing innovative healthcare products to improve people's lives? Ÿ Ÿ We create smart devices to measure relevant biomarkers anytime, anywhere, without pain: To make people's lives easier and safer by monitoring their parameters without even noticing them. We would improve patients' quality of life and emotional estate. Ÿ June 2022 43|www.insightscare.com

46. Novel Perspective How to Transform Present Healthcare Systems into Patient-Centric Wellness Ecosystem A know it, keeping in mind that technological progress has been extremely rapid and is increasingly orienting towards patient-centric principles. look at the evolution of technology use in healthcare reveals a dynamic and fascinating series of events that led to the digital health age as we e-Patients, e-Physicians, and Smart Hospitals According to patient-centered care, a partnership has developed between the patient and the provider, and the patient is encouraged to actively participate in disease management as well as be involved in decision-making. Furthermore, patients are increasingly relying on the internet for health information. As a result, today's patient is "empowered, engaged, equipped, and enabled," in addition to being digitally savvy, resulting in the birth of an e- Patient. The 1960s, combined with advances in information and communication technology (ICT) and the pressing need to make healthcare accessible in remote areas, carved the way for technological application in the healthcare space and the emergence of Telemedicine, which literally means "healing at a distance" took place. In this article, we will explore some of the technological trends that are shaping the healthcare systems to be patient-centric wellness ecosystems. Doctors are slowly but steadily embracing and implementing technology. Through smarter scheduling and task organization, e-Physicians are increasingly benefiting from the opportunities provided by smartphones in clinical decision-making and better service coordination. June 2022 44|www.insightscare.com

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48. Electronic Medical Records (EMR) Hospital facilities are also evolving in tandem, utilizing technological innovations to improve patient care and safety during their stay, such as installing automation systems in the building to regulate temperature and ventilation and installing smart locks. Smart patient care processes are ensured by interconnected clinical information systems such as Laboratory Information Systems. Furthermore, identification systems allow patients, hospital staff, and hospital equipment to be authenticated and tracked. EMRs, which can store a patient's health and medical information in digital form, has piqued the interest of many physicians. It not only improves communication among members of the health care team but also provides them with readable and organized information, lowering the risk of medical errors. Health Portals Teleconsultation and Remote Patient Monitoring Portals are personal healthcare-related websites that allow patients to communicate with their healthcare team via teleconsultations, with the goal of bridging the communication gap between patients and providers. They also allow access to lab test results, scheduling appointments with doctors, and refilling prescriptions. According to a systematic review of the effect of patient portals, ten out of twenty-seven studies reported favorable effects in terms of medication adherence, self-care practices, improved patient satisfaction, and functional status. The abundance of opportunities for effective communication made possible by technological advancements has laid the groundwork for real-time consultations between health providers and patients separated by geographical distance, a process known as teleconsultation, bridging the communication gap between them. Remote patient monitoring (RPM) is a more robust form of teleconsultation that uses cutting-edge IT tools to provide diagnostic and treatment services to patients in remote and rural areas. Big Data Internet as the Source of Health Information A large and complex volume of data known as Big Data is being produced as a result of the digitization of medical and health records (EMRs) and data generated from wearable devices. This massive repository of data is now being used to assist clinicians in providing an observational evidence base. Big Data has also made it possible to provide personalized treatment by combining genomics and EMR analytics. With internet access at an all-time high, approximately eight out of ten Americans use the internet as a source of health-related information. A digital-age patient now has access to an infinite amount of information. Online medical encyclopedias like MedlinePlus provide in-depth information on diseases, tests, symptoms, and treatment. Help-seeking behavior for mental health issues using online information is on the rise among young adults. Conclusion Wearable Sensors The paradigm shift in healthcare delivery toward patient- centered care has restructured the dynamics of the patient- provider relationship, allowing patients to take an active role in protecting their own health. Although this area of health care is still in its early stages due to slow adoption and a long way to go in terms of implementation, evidence- based, and regulatory framework development, excitement is building due to its unprecedented potential in disease treatment, disease prevention, and health promotion. It has the ability to reach out to every person in need of healthcare at every level and may thus prove to be a silver lining in the healthcare system. Patients with chronic diseases such as cardiovascular disease and diabetes can now monitor their vital signs such as blood pressure and blood glucose levels using miniaturized, sensor-enabled wearable devices and thus engage in self-care. It also enables the patient to wirelessly transmit the data obtained to a health care professional. A study emphasized the viability of wearable devices in promoting physical activity and weight loss. Furthermore, data obtained from wearable sensors alert the patient and the healthcare team to adverse events and prompt, timely corrective action. - Trishika Rokade June 2022 46|www.insightscare.com

50. Spain's Top 10 Companies Booming in Healthcare Sector 2022 Top Doctors Helping you find doctors at your fingertip C are changes in your insurance or if your old doctor is retiring. Additionally, visiting a doctor physically can often be viewed as a hectic process, especially if you are severely ill. Please give us a brief overview of Top Doctors' journey in the healthcare niche, highlighting the USPs of your company. hoosing the right doctor can be challenging, especially if you have moved out to a new setting. It can also be difficult to search for a doctor if there Top Doctors is the only platform that allows patients to choose a doctor based on quality information showing the doctors most recommended by other specialists and the real experiences of other patients. Providing a one-stop virtual solution to the above challenges is Top Doctors, an online platform that helps patients make their choice by selecting the best-in-class specialists across the globe. With its patient-centric approach, the organization has built a device that is accessible from the comfort of your home. Additionally, our unique search algorithm is based on matching the pathology, treatment, or disease experienced by the patient, with the doctor's expertise, with a focus on specialist (secondary) care. As a result, the patient can easily find the right expert for them for each pathology, treatment, or disease. In an interview with Insights Care, the President, and CEO Alberto E. Porciani spoke about this innovative approach and its impact on the healthcare niche. Below are the highlights: Finally, we also offer online booking for face-to-face visits and telemedicine services where medical consultations with the most prominent doctors can be carried out immediately and without geographical limitations. This is crucial, especially for patients who live in 'medical deserts' (areas with a limited number of specialists). Please tell us about Top Doctors in detail. Top Doctors is an online platform gathering selected best- in-class specialists across more than 50 specialties (orthopedic surgeons, dermatologists, ophthalmologists) in eight countries (Europe, LATAM, and the Middle East). What is unique about Top Doctors is that we have developed a selection process of top specialists. Our selection process is a combination of two main areas: peer- to-peer recommendation, where doctors nominate another doctor because they believe they are among the best in their field and would recommend them to friends or family, and on top of that, we have our internal auditing of doctors' Cvs. Today, over 90,000 clinical specialists are referenced on the platform as best doctors following a thorough screening and peer-to-peer and patients ratings selection process realized by TD. TD's offering to specialists is focused on online reputation management, online booking assistance, teleconsultation solutions, and other tech solutions that help improve doctors' and clinics' practice management and increase the traffic of better-qualified patients. Only one in five doctors pass our rigorous selection process. Finally, we also combine information about the doctor with patients' ratings to maintain the highest standard of quality. What are the core values upon which your organization is built? What is the vision and mission of Top Doctors? The platform is free for patients, generates +275m web visits per year, and contributes to solving the specialist's medical-desert issues across the globe. The mission of Top Doctors is to make it easy for patients to find and get access to the best specialists worldwide through IT solutions. June 2022 48|www.insightscare.com