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Introduction to Systems Biology Project 9

Introduction to Systems Biology Project 9. In silico symbiosis of Strepptococcus Thermophilus and Mus Musculus. Strepptococcus Thermophilus.

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Introduction to Systems Biology Project 9

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  1. IntroductiontoSystemsBiologyProject 9 In silicosymbiosis of StrepptococcusThermophilus and MusMusculus

  2. StrepptococcusThermophilus • “Streptococcus thermophilus is an essential lactic acid bacterium used for commercial purposes, which includes the production of milk, cheese, and other dairy products.” • „Lactic acid bacteria (LAB) are of great importance in the food industry because of their lactic acid production and their characteristic impact (e.g., texture, flavor) on the final product.”

  3. Symbiosis • Westudythemetabolicinteractions of a mouse and it‘s gutmicrobe, StrepptococcusThermophilus. • Matlab is usedtomodelthemetabolicnetworks and thecorrespondinginteractionsbetweentheorganisms. • Optimizationtechniquesareusedtocomparebiomassgrowthondifferentdiets. • Westudyhowthepresence of oneorganismeffectsbiomassgrowth in theother.

  4. Biomassgrowthrate(BGR) • Biomassgrowthrate is optimized for theorganismsonfourdifferentdiets, bothbiassociated (in symbiosis) and monoassociated (withoutsymbiosis). Highprotein Low fat / highcarb Lowcarb / high fat Western diet

  5. Highprotein diet • Mouse BGR is highestonthehighprotein diet • Presence of Strepptococcusgreatlyincreasesmouse BGR

  6. Highcarb diet • Strepptococcus BGR is highestonhighcarb diet • Presence of Strepptococcusgreatlyincreasesmouse BGR

  7. High fat diet • Presence of Strepptococcusgreatlyincreasesmouse BGR • Samemaximumgrowth rates for mouse as highcarb. Mammalsneedprotein and protein is limitedto 20% in bothcases.

  8. Western diet • Mouse BGR is lowestonwestern diet. Probablyduetolowamount of protein in the diet selected(15%). • Presence of Strepptococcusgreatlyincreasesmouse BGR

  9. Metabolicinteractions • Themain part of theproject is thestudy of the metabolite exchangebetweenthetwoorganisms – thesymbioticinteractions. • FluxVariability Analysis is usedtostudywhich metabolites areexchangedundergiven, extremeconditions. (e.g. maxmousegrowth, maxstrepptogrowthand whentheyarecompeting for resources) • Themetabolicsystem is dividedintothemicroorganism, themouse and themutuallumen. • A lumen (Lat. lūmen, an opening) in biology is the inside space of a tubular structure, such as an artery or intestine. By extension, a lumen can also be the inside space of a cellular component or structure, such as the endoplasmic reticulum. • Thegoal is tostudybothnutrientintakeand secretion of theorganisms and alsotheinteractionsbetweenthelumen and microorganism/mouse.

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