1 / 172

Collaborative Islet Transplant Registry (CITR) 2010 Annual Report Exhibits

Collaborative Islet Transplant Registry (CITR) 2010 Annual Report Exhibits

jack
Download Presentation

Collaborative Islet Transplant Registry (CITR) 2010 Annual Report Exhibits

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Collaborative Islet Transplant Registry (CITR) 2010 Annual Report Exhibits Prepared by:CITR Coordinating CenterThe EMMES CorporationRockville, MDSponsored by:National Institute of Diabetes & Digestive & Kidney DiseasesNational Institutes of HealthJuvenile Diabetes Research FoundationDatafile Closure: March 21, 2011

  2. Collaborative Islet Transplant Registry 2010 • Follow-up time after initial infusion for each recipient. Top: islet after kidney (N=65), bottom: islet alone (N=347). Yellow: insulin independence; green: insulin-using with graft function (70% average reduction in daily insulin use from baseline); black: no islet function; gray: missing data. Red marks indicate re-infusions. Pie charts show percent of all follow-up time with insulin independence.

  3. Chapter 1: Islet Transplant Activity Chapter 2: Recipient and Donor Characteristics Chapter 3: Pancreas Procurement, Islet Processing, and Infusion Characteristics Chapter 4: Immunosuppression and Other Medications Chapter 5: Graft Function Chapter 6: Liver, Kidney, Lipid, and PRA Effects Chapter 7: Adverse Events Chapter 8: Registry Data Quality Review CITR Coordinating Center CITR Committees Table of Contents

  4. Chapter 1: Islet Transplant Activity

  5. CITR Recipients, Infusions and Donors byNIDDK/JDRF Sites and by ITA/IAK/SIKConsented, Registered and First Infused in 1999-2009

  6. Cumulative Enrollment in CITR

  7. Islet Transplant Centers Reporting Data to CITRParticipating North American Centers 1999-2009 A - CITR Centers with at least one islet allograft infusion procedure conducted in 2008C - CITR Centers with no islet allograft infusions in 2008D - CITR Coordinating Center

  8. Islet Transplant Centers Reporting Data to CITRParticipating European Centers 1999-2009 A - CITR Centers with at least one islet allograft infusion procedure conducted in 2008 B - CITR Centers with data reports pending

  9. Islet Transplant Centers Reporting Data to CITRParticipating Australian Centers 1999-2009 A - CITR Centers with at least one islet allograft infusion procedure conducted in 2008 C - CITR Centers with no islet allograft infusions in 2008

  10. Number of Islet Transplantation Centers Performing Islet Allograftsper Year and Number with Data Entered in CITR Database All North American Islet Transplant Centers 1999-2009

  11. Total Number of Islet Allograft Recipients, Recipients at CITR-Participating Centers, and Recipients with Detailed Data Reported to CITR by Year of First Islet Allograft InfusionAllograft recipients at North American Islet Transplant Centers 1999-2009

  12. Total Number of Islet Allograft Recipients and Recipients with Detailed Data Reported to CITR by Year of First Islet Allograft InfusionCITR-Participating European and Australian JDRF Centers1999-2009

  13. Total Number of Islet Allograft Infusion Procedures Performed andNumber with Data Reported to CITRCITR-Participating North American Islet Transplant Centers 1999-2009

  14. Total Number of Islet Allograft Infusion Procedures Performed and Number with Data Reported to CITRCITR-Participating European and Australian JDRF Centers1999-2009

  15. Islet Allograft Infusions by Infusion Sequence Number and YearCITR-Participating North American and JDRF Centers, 1999-2009

  16. Islet Allograft Recipients by Total Infusions to Date and YearCITR-Participating North American and JDRF Centers, 1999-2009

  17. Total Number of Islet Allograft Infusions Per Recipient:CITR-Participating North American and JDRF Centers, 1999-2009

  18. Total Number of Deceased Donors per Islet Allograft InfusionCITR-Participating North American and JDRF Centers, 1999-2009

  19. Allograft Islet Alone and Islet After Kidney and Simultaneous Islet-Kidney Autograft RecipientsParticipating North American and JDRF Centers, 1999-2009

  20. Chapter 2: Recipient and Donor Characteristics

  21. Recipient Demographics

  22. Recipient Demographics (continued)

  23. Recipient Characteristics at First Infusion

  24. Recipient Diabetes Characteristics and Medical History

  25. Recipient Diabetes Characteristics and Medical History (continued)

  26. Recipient Diabetes Characteristics and Medical History (continued)

  27. Recipient Diabetes Characteristics and Medical History (continued)

  28. Recipient Autoantibodies and Sensitization at First Infusion

  29. Recipient Autoantibodies and Sensitization at First Infusion (continued)

  30. Recipient Infectious Disease Testing at First Infusion

  31. Recipient Characteristics Prior to First Infusion by Total Number of Infusions Received

  32. Recipient Baseline Autoantibodies by Total Infusions Received

  33. Recipient Laboratory Values at First Infusion

  34. Donor Demographics

  35. Donor Characteristics

  36. Donor Characteristics (continued)

  37. Donor Hospitalization

  38. Donor Hospitalization (continued)

  39. Donor Hospitalization (continued)

  40. Donor Serology

  41. Donor Laboratory Data

  42. Organ Crossmatch Results

  43. Chapter 3: Pancreas Procurement, Islet processing and Infusion Characteristics

  44. Islet Processing Summary

  45. Islet Processing Summary (continued)

  46. Pancreas Digestion Combinations Involving Thermolysin/Pulmozyme

  47. Final Islet Preparation Microbiology (Positive)

  48. Cold Ischemia Information

  49. Islet Product Characteristics

  50. Islet Product Characteristics by Infusion Sequence

More Related