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N on H omologous E nd J oining

N on H omologous E nd J oining. Homologous Recombination. Non Homologous End Joining. Differences between HR and NHEJ :. Error- free / Error- prone Cell cycle regulated Varies between species. plants. yeast. mammals. NHEJ. HR. HR. NHEJ. Cell-induced Double Strand Brakes.

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N on H omologous E nd J oining

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  1. Non Homologous End Joining

  2. Homologous Recombination Non Homologous End Joining

  3. Differences between HR and NHEJ: • Error- free / Error- prone • Cell cycle regulated • Varies between species plants yeast mammals NHEJ HR

  4. HR NHEJ Cell-induced Double Strand Brakes MHC rearrangement Meiosis

  5. V(D)J recombination

  6. NHEJ Defects • SCID (Severe Combined Immune Deficiency). • Cancer – genome instability: rearrangements, deletions, amplifications.

  7. Ku 70/80 heterodimer

  8. Ku has a role in telomeres ?

  9. KU 70/80

  10. Ku is critical for telomere maintenance

  11. Ku Plays Several Roles at Telomeres Telomere addition Telomeric silencing

  12. Ku is a multifunctional protein

  13. NHEJ HR

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