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Gallbladder Disease in Infants and Children

Gallbladder Disease in Infants and Children. 2010 WOFAPS Meeting George W. Holcomb III, MD, MBA Surgeon-in-Chief Children’s Mercy Hospital Kansas City, Missouri. Ann Surg 191:626-635, 1980. Biliary Disease. Gallstones Hemolytic disease Non-hemolytic disease Biliary dyskinesia

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Gallbladder Disease in Infants and Children

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  1. Gallbladder Disease in Infants and Children 2010 WOFAPS Meeting George W. Holcomb III, MD, MBA Surgeon-in-Chief Children’s Mercy Hospital Kansas City, Missouri

  2. Ann Surg 191:626-635, 1980

  3. Biliary Disease • Gallstones • Hemolytic disease • Non-hemolytic disease • Biliary dyskinesia • Acalculous disease

  4. Nonhemolytic Total parenteral nutrition Gallbladder stasis Lack of enteral feeding Ileal resection (necrotizing enterocolitis and Crohn’s disease) Biliary tract anomalies Adolescent pregnancy Oral contraceptives Hemolytic Sickle cell disease Spherocytosis Thalassemia Risk Factors for Cholelithiasis in Infants and Children

  5. Biliary Dyskinesia • Symptomatic biliary colic w/o stones • Reduced GBEF with CCK stimulation • IU study – 37 pts – 71% resolution of symptoms • GBEF < 15% successful resolution of symptoms (O.R. – 8.00) • Chronic cholecystitis seen on histological examination of many specimens

  6. Symptoms • Epigastric/RUQ pain • Nausea/vomiting • Fatty food intolerance • Painless jaundice • Pancreatitis

  7. Imaging Studies • Ultrasound • Radionucleide gallbladder emptying study (with CCK) • Hepatobiliary scan

  8. Complicated Cholelithiasis • Acute cholecystitis • Jaundice • Pancreatitis

  9. Timing of Cholecystectomy • Non-complicated – 0 – 14 days • Complicated • Jaundice – following work-up • Cholecystitis – 2-4 days • Pancreatitis – once resolved

  10. When to Suspect Choledocholithiasis? • Elevated bilirubin (jaundice) • Elevated lipase, amylase (pancreatitis) • Dilated CBD or stone(s) in CBD on ultrasound

  11. MANAGEMENT OF SUSPECTED CHOLEDOCHOLITHIASIS(PRE-OPERATIVELY)

  12. Management Options • Pre-op ERCP, sphincterotomy, stone extraction • Laparoscopic or open CBD exploration at time of cholecystectomy • Post-op ERCP, sphincterotomy, stone extraction (adults)

  13. Factors • Surgeon’s experience with laparoscopic CBD exploration • Availability of an endoscopist to perform ERCP inchildren

  14. 14/131 suspected choledocholithiasis J Pediatr Surg 32:1116-1119, 1997

  15. Algorithm Suspected Choledocholithiasis

  16. Why ERCP First? • Surgeon knows at time of laparoscopic cholecystectomy whether CBD (laparoscopic or open) exploration needed • Potentially avoids a third anesthesia and operation

  17. Disadvantage A number of ERCPs will be performed in patients that do not have CBD stones

  18. IS ROUTINE CHOLANGIOGRAPHY NEEDED?

  19. Cholangiography • 1990-1995: Reasonable to perform cholangiography to become facile with technique • 2010: Most surgeons have become facile with this technique

  20. Cholangiography • To evaluate for CBD stones • To define anatomy

  21. My Approach • Reserve cholangiography for cases where anatomy is unclear • Use ultrasound pre-operatively to define CBD involvement

  22. Pre-operative Ultrasound • Prior to laparoscopic cholecystectomy • Confirm stones, evaluate for CBD dilation or stones • Cost-effective strategy

  23. Financial analysis of preoperative ultrasonography versus intraoperative cholangiography for detection of choledocholithiasis at Children's’ Mercy Hospital, Kansas City MO 2007

  24. Cholangiography Cystic Duct Cannulation Kumar Clamp Technique

  25. Kumar Clamp Technique Surg Endosc 8:927-930, 1994

  26. Where do I place the instruments/ports for a laparoscopic cholecystectomy?

  27. Port Placement

  28. Stab Incision Technique • 2 cannulas • 2 stab incisions

  29. Key Steps in Operation • Begin dissection high on gallbladder to expose triangle of Calot

  30. Key Steps in Operation • Create 90 b/w cystic duct and CBD

  31. What Do I Do If I Cut the Common Bile Duct?

  32. Options • Ligate duct • wait for it to enlarge • transfer to experienced biliary surgeon • Repair laparoscopically • Repair open • interrupted sutures • T – tube • choledochojejunostomy at second operation

  33. CMH Experience 2000 - 2006 • 224 Pts (# female) • (12.9 yrs, 58.3 kg) • Indication • Symptomatic gallstones 166 • Biliary dyskinesia 35 • Gallstone pancreatitis 7 • Gallstones/splenectomy 6 • Calculous cholecystitis 5 • Other 4 IPEG, 2007 J Laparoendosc Adv Surg Tech 18:127-130, 2008

  34. CMH Experience2000-2006 • Mean operative time 77 min • Cholangiograms – Intraoperatively 38 • Stones 9 • Cleared intraop 5 • Cleared postop 4 Preoperatively (ERCP) 17 • Stones found 8 • Ductal injuries 0 IPEG, 2007 J Laparoendosc Adv Surg Tech 18:127-130, 2008

  35. www.cmhcenterforminimallyinvasivesurgery.com

  36. References • Rau B, Friesen CA, Daniel JF, Qadeer A, You-Li D, Roberts CC, Holcomb GW III: Gallbladder wall inflammatory cells in pediatric paitents with biliary dyskinesia and cholelithiasis: a pilot study. J Pediatr Surg 41:1545-1548, 2006. • Carney DE, Kokoska ER, Grosfeld JL, Engum SA, Rouse TM, West KM, Ladd A, Rescorla FJ: Predictors of successful outcome after cholecystectomy for biliary dyskinesia. J Pediatr Surg 39:813-6, 2004 • Patel NA, Lamb JJ, Hogle NJ, Fowler DL: Therapeutic efficacy of laparoscopic cholecystectomy in the treatment of biliary dyskinesia. Am J Surg 187:209-12, 2004. • Holcomb GW III, Sharp KW, Neblett WW III, Morgan WM III, Pietsch JB: Laparoscopic cholecystectomy in infants and children: Modifications and cost analysis. J Pediatr Surg 29: 900-904, 1994. • Holzman MD, Sharp K, Holcomb GW III, Frexes-Steed M, Richards WO: An alternative technique for laparoscopic cholangiography. Surg Endosc 8:927-930, 1994. • Holcomb GW III, Morgan WM III, Neblett WW III, Pietsch, JB, O’Neill JA Jr. Shyr Y: Laparoscopic cholecystectomy in children: Lessons learned from the first 100 patients. J Pediatr Surg 34: 1236-1240, 1999. • Newman KD, Holcomb GW III, Powell DM: The management of choledocholithiasis in children in the era of laparoscopic cholecystectomy. J Pediatr Surg 32: 1120-1123, 1997. • Hadigan C, Fishman SJ, Connolly LP, et al: Stimulation with fatty meal (Lipomul) to assess gallbladder emptying in children with chronic acalculous cholecystitis. J Pediatric Gastroenterol Nutr 2003; 37:178-82. • Mayer EA, Collins SM: Evolving pathophysiologic models of functional gastrointestinal disorders. Gastroenterology 2002; 122:2032-48. • Campbell BT, Narasimhan NP, Golladay ES, Hirschl RB: Biliary dyskinesia: a potentially unrecognized cause of abdominal pain in children. Pediatr Surg Int 2004, 20:579-81, Epub 2004. • Shaffer E: Acalculous biliary pain: new concepts for an old entity. Dig Liver Dis 35 Suppl 3:S20-5, 2003. • Finan KR, Leeth RR, Whitley BM, Klapow JC, Hawn MT: Improvement in gastrointestinal symptoms and quality of life after cholecystectomy. Am J Surg 192:196-202, 2006. • Taylor E, Wong C: The optimal timing of laparoscopic cholecystectomy in mild gallstone pancreatitis. Am Surg 70:971-5, 2004.

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