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Clinical Working Memory Testing Device: “ The Memory Scope”

The Memory Scope is a memory testing device that can detect working memory damage using the Tarnow Unchunkable Test (TUT), developed by Eugen Tarnow. It is independent of language/culture, gender, and shows promise in distinguishing between Alzheimer's Disease (AD) and Normal/Mild Cognitive Impairment (MCI).

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Clinical Working Memory Testing Device: “ The Memory Scope”

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  1. Clinical Working Memory Testing Device:“The Memory Scope” Eugen Tarnow Director Avalon Business Systems 19-03 Maple Avenue etarnow@avabiz.com 1-646-825-9080

  2. Overview • Memory damage will become more widespread as a greater portion of Americans become senior citizens and live longer. Geriatric care professionals need to having testing equipment ready: a “memory scope”. • Short term memory consists of two parts: • Working memory (with 3 or 4 items) • Reactivation memory (associations based on working memory content) • Tarnow first one to prove this (previously believed to be the case but not proven) • Memory testing device MeMo can detect working memory damage. It uses the working memory test called the Tarnow Unchunkable Test (TUT). 1-646-825-9080

  3. Pilot test at Mt. Sinai Alzheimer’s Research Center • Test of normal aged subjects showed that TUT was: • Independent of language/culture (English, Mandarin, Cantonese & Spanish) • Independent of gender • Small dependency with age and education • When including Mild Cognitive Impairment (MCI) and AD subjects: • TUT distinguishes between AD and Normal/MCI. • TUT does not distinguish between Normal and MCI. • TUT best of all number tests • AD differs from Normal/MCI by • Damage to working memory. Identified by TUT (for the first time?). 1-646-825-9080

  4. Pilot test at Mt. Sinai Alzheimer’s Research Center Field MCI* Normal* Importance LogUnits 26.067 12.125 1.000 MEMUNITS12.300 4.625 1.000 LOGIMEM 13.767 7.500 1.000 MMSE 29.200 26.875 0.996 ANIMALS 19.667 13.250 0.990 AniVeg 33.333 24.125 0.988 BOSTON 26.400 22.250 0.980 VEG 13.667 10.875 0.926 TRAILB 105.929 150.429 0.845 DIGIB 7.267 6.250 0.740 DIGIF 7.690 8.250 0.430 TUT-3 2.639 2.583 0.210 TRAILA 46.700 49.250 0.152 Field Not AD* AD* Importance MMSE 28.711 21.800 1.000 LOGIMEM 12.447 3.000 1.000 LogUnits 23.132 3.600 1.000 MEMUNITS10.684 0.600 1.000 TUT-3 2.629 1.667 0.999 BOSTON 25.526 19.600 0.980 VEG 13.079 8.800 0.978 AniVeg 31.395 21.200 0.975 TRAILB 114.829 200.000 0.961 ANIMALS 18.316 12.400 0.941 DIGIB 7.053 5.600 0.818 DIGIF 7.811 7.000 0.504 TRAILA 47.237 52.200 0.255 1-646-825-9080

  5. Alzheimer’s disease – example of damage to working memory • Alzheimer’s disease (AD) starts out with damage to reactivation memory (MCI) and proceeds with working memory damage. • MCI • Sensitive to complexity of one’s memory • Hard to know if MCI will lead to AD. • When AD is diagnosed, the person has difficulties with daily living, presumably because the working memory is damaged. • Identifying working memory damage will flag difficulties in daily living. 1-646-825-9080

  6. Other damage to working memory • Strokes • Schizophrenia • Dyscalculia 1-646-825-9080

  7. Measures user’s ability to recall sets of displayed integers and signals user when it detects AD-specific-recall patterns. Integers are 21-98 and avoid easy-to-remember numbers like 50 or 88 and numbers that are close (patent application submitted) Simple design means that it will not need new batteries for years. Hand-held device with large-print friendly to seniors. Easy to wipe off. TUT test patent pending – needs lawyer time Solution: Memory Scope 1-646-825-9080

  8. Competition • Computer tests • Online • iPad • Software • MeMo advantage • Always on and ready. • No need to figure out how to get to the particular computer program or app • Saves time • No language needed – works on diverse populations 1-646-825-9080

  9. Sales and Marketing • Sales & marketing: Copy stethoscope strategy • Customers: • 200,000 primary care physicians • 67,000 pharmacies (make sure patients can follow instructions) • 28,000 assisted living facilities • DIY people • FDA will not approve any computer test as an aid in diagnosis of Alzheimer’s 1-646-825-9080

  10. Forecast • Assumptions • 10% of primary physicians, pharmacies and assistant living facilities buy it every year • Selling Price is $175 • Marketing and Administrative Cost is $10 • Distribution Cost is $7 • Production Cost is $5 1-646-825-9080

  11. Forecast (continued) 1-646-825-9080

  12. Team • Eugen Tarnow • PhD from Massachusetts Institute of Technology • Author of Numerous Papers on Topics Including Physics, Neuroscience, Management Science, and Publication Ethics • Edward Reep • Bachelor of Science in Supply Chain and Marketing Science from Rutgers University • Consults on Projects at Avalon Business Systems 1-646-825-9080

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