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Integrated Fluorescent Probe & Radiofrequency Ablator

Integrated Fluorescent Probe & Radiofrequency Ablator. Rachel Riti & Alex Walsh Advisors: Bart Masters & Anita Mahadevan-Jansen. Outline. Background – RFA, Fluorescence Motivation Objective Performance Criteria Proposed Designs Future Work. Radiofrequency Ablation.

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Integrated Fluorescent Probe & Radiofrequency Ablator

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  1. Integrated Fluorescent Probe & Radiofrequency Ablator Rachel Riti & Alex Walsh Advisors: Bart Masters & Anita Mahadevan-Jansen

  2. Outline • Background – RFA, Fluorescence • Motivation • Objective • Performance Criteria • Proposed Designs • Future Work

  3. Radiofrequency Ablation • Ablation of tissue using high frequency radio waves • Applied in lung, kidney, breast, bone and liver tumors

  4. Fluorescence • Emission of light by a substance that has absorbed light of a different wavelength • Property of biological tissue • Collagen, NADH, Elastin

  5. Motivation • Determination of ablated area • Current Method • Thermocouples • Alternative Methods • Tissue Markers, Thermal Camera • Proposed Method • Fluorescence

  6. Temperature Dependence of Fluorescence Walsh A, Masters DB, Jansen ED, Welch AJ, Mahadevan-Jansen A, The Effect of Temperature on Fluorescence: An Animal Study, Lasers in Surgery and Medicine. Publishing Pending

  7. Objective • Design a probe capable of both fluorescence and measurements of RFA • Build the designed probe • Test the probe

  8. Performance Criteria • Maintain RFA efficiency • Determine region of ablation • Accuracy • Within 10% of original fluorescence intensity • Determine margins of ablation within 5% Brainstorming Ideas

  9. Prototype 1 15 cm RFA Probe 19 cm Fiber optic Laser

  10. Validation • RFA functionality not compromised • Fiber functional during RFA • Probe entry not affected • Observable significant difference between ablated and normal tissue • Measurement of ablation area

  11. Prototype 2 Fiber enclosed 2-5 cm 15 cm

  12. Validation • RFA functionality not compromised • Fiber functional during RFA • Probe entry not affected • Adjustable fiber length during procedure • Fluorescence measurements accurately indicate ablation area

  13. Timeline

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