1 / 12

Ian Marshall, Maurits A Jansen, Yuehui Tao, Gavin D Merrifield, Gillian A Gray

Accelerated mouse cardiac imaging using threefold undersampling and kt-BLAST reconstruction. 3847. Ian Marshall, Maurits A Jansen, Yuehui Tao, Gavin D Merrifield, Gillian A Gray University of Edinburgh. Computer 35. Mouse kt-BLAST cardiac imaging 3847. Introduction. Why acceleration?

Download Presentation

Ian Marshall, Maurits A Jansen, Yuehui Tao, Gavin D Merrifield, Gillian A Gray

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Accelerated mouse cardiac imaging using threefold undersampling and kt-BLAST reconstruction 3847 Ian Marshall, Maurits A Jansen, Yuehui Tao, Gavin D Merrifield, Gillian A Gray University of Edinburgh Computer 35

  2. Mouse kt-BLAST cardiac imaging3847 Introduction Why acceleration? - shorter scan times, reduced costs, - improved patient compliance - reduced animal burden Parallel imaging now widely used clinically (some) kt-undersampling for human cardiac scanning Limited translation of techniques to rodent imaging - would improve animal welfare (3Rs)

  3. Mouse kt-BLAST cardiac imaging3847 Study design 6 healthy + 2 MI adult mice Cardiac MRI scans in short-axis plane Standard CINE sequence 3-fold accelerated ktBLAST sequence + training data Comparison of image quality and cardiac indices EDV, ESV, EF, EDM, ESM

  4. Mouse kt-BLAST cardiac imaging3847 Scanning details 7T scanner (Agilent Technologies) 39 mm quad coil Respiratory gating and cardiac triggering CINE Gradient Echo sequence - (12 frames, 192×192, FOV 30 mm, 3 Averages) kt-BLAST sequence (Tsao MRM 2003) - 3× undersampling (linear grid) - 16 central training rows

  5. Mouse kt-BLAST cardiac imaging3847 Image analysis One analyst, blinded to type of images Subjective quality (scale 1-5) Endo- and epicardial borders drawn manually Cardiological indices derived

  6. Mouse kt-BLAST cardiac imaging3847 Images fully sampled 3× undersampled

  7. Mouse kt-BLAST cardiac imaging3847 “Ratios” •=MI

  8. Mouse kt-BLAST cardiac imaging3847 Bland-Altman plot EDV MI MI

  9. Mouse kt-BLAST cardiac imaging3847 Results summary Image quality: 4.3±1.2 (full) versus 3.8±1.4 (ktBLAST) Cardiological indices (σ)wrt fully sampled images “Ratios” Bland-Altman bias EDV 0.94 (0.07) -5 (8) μL ESV 1.06 (0.14) 2 (6) μL EF 0.93 (0.08) -5 (5) % EDM1.11 (0.10) 13 (12) mg ESM 1.01 (0.06) 1 (8) mg

  10. Mouse kt-BLAST cardiac imaging3847 Discussion kt-BLAST images have similar “quality” “Ratios” biased up to 11% (for EDM) - corresponding Bland-Altman bias 13 mg Observer variability 3-10% (Heijman JMRI 2008) MI mice (large hearts and small EF) Overall acceleration 2.4× Compare with Compressed Sensing (Wech JMRI 2011)

  11. Mouse kt-BLAST cardiac imaging3847 Conclusion Accelerated cardiac imaging of mice is feasible Threefold acceleration gives acceptable results This enables - increased throughput - improved animal welfare

  12. Mouse kt-BLAST cardiac imaging3847 Acknowledgements Peter Hoskins Tom Anderson Steven Fortune Mike Davies Gabriel Rilling Ross Lennen Agnieszka Kozak

More Related