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Review of Existing PRO Coverage of AD-related entities

Review of Existing PRO Coverage of AD-related entities. Darren A. Natale, PhD Protein Information Resource Georgetown University Medical Center. Our Efforts: Scratched the surface. APP: isoforms, sequence variants, cleavage products Tau: isoforms, phosphorylation PTMs

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Review of Existing PRO Coverage of AD-related entities

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  1. Review of Existing PRO Coverage of AD-related entities Darren A. Natale, PhD Protein Information Resource Georgetown University Medical Center

  2. Our Efforts: Scratched the surface • APP: isoforms, sequence variants, cleavage products • Tau: isoforms, phosphorylation PTMs • Secretases: components only, no complexes yet • Nearly all information on isoforms and sequence variants have come from UniProtKB, as have leads on PTM combinations (need to re-read the literature) • Need a more comprehensive source

  3. AlzForum Antibodies

  4. Challenges • Numbering for PTMs in AD community differs from that used by PRO (AD=Tau-F; UniProtKB=PNS-Tau) • AlzForum resource (Antibodies) indicates PTM sites in free text that varies in form • PRO currently lacks structured way to indicate positions of PTMs • Have to take into account cross-reactants

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