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Targeting Systems: New Strategy for Computational Biology in Traditional Chinese Medicine

Targeting Systems: New Strategy for Computational Biology in Traditional Chinese Medicine. Yun Wang Research Center for TCM Information Engineering Beijing University of Chinese Medicine yunwang@yahoo.cn. Outline. Background Systems: the way for TCM to realize the clinical effects

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Targeting Systems: New Strategy for Computational Biology in Traditional Chinese Medicine

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  1. Targeting Systems: New Strategy for Computational Biology in Traditional Chinese Medicine Yun Wang Research Center for TCM Information Engineering Beijing University of Chinese Medicine yunwang@yahoo.cn

  2. Outline • Background • Systems: the way for TCM to realize the clinical effects • Targeting systems • A Proposed Platform for System-targeting TCM research • A Simple Example

  3. Background • Purpose 1: Explain the functional mechanism of TCM • Purpose 2: Provide lead compounds for structure optimization • Focus on: discovery of active components from TCM Unfortunately: • 1. weak effect of the components • 2. activity dispersion during component separation • 3. no better than “western medicine”, no better than TCM • 4. seldom successful stories.

  4. Systems: the way for TCM to realize the clinical effects • Fact1: Weak effect of components • Fact2: Validated effect of TCM by clinical practice • Inference: Interaction among components Indirect Interaction (often) TCM related Biological system Direct Interaction (seldom) TCM function • Systems are the targets of TCM function

  5. Targeting systems: interpreting the mechanism of TCM function Indirect Interaction (often) TCM related Biological system Direct Interaction (seldom) Mechanism of TCM function

  6. Targeting systems: bridging biology and TCM theory Indirect Interaction (often) TCM related Biological system Direct Interaction (seldom) TCM function TCM theory

  7. Targeting systems: providing new cues for the treatment of complex disease Indirect Interaction (often) TCM related Biological system Direct Interaction (seldom) TCM function TCM theory Validated clinical prescription

  8. Targeting systems: providing new resource for drug development • Impact based molecular target selection • “Remote” interruption of systems • Complex drugs Indirect Interaction (often) TCM related Biological system Direct Interaction (seldom) TCM function TCM theory Validated clinical prescription

  9. A Proposed Platform for System-targeting TCM research TCM pathway Database Active compnts mol targets bio systems

  10. Biological Systems related with TCM Prescriptions that Promoting Blood Circulation and Removing Blood Stasis Map00100: biosynthesis of steroids Map00010: glycolysis /gluconeogenesis Map00230: purine metablism Map00590:prostaglandin and leukotriene metabolism Map00531: glycosaminoglycan degradation

  11. Gaëlle Hardy, et. al. Urinary leukotriene E4 excretion is increased in type 1 diabetic patients A quantification by liquid chromatography–tandem mass spectrometry. Prostaglandins Other Lipid Mediat.2005. 78(1-4):291-299 220 paper’s title in CNKI contaning: promoting blood circulation and removing blood stasis + diabetes

  12. Thanks for Your Attention!

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