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ISMRM 2010

ISMRM 2010. Quantitative Imaging and MS. N. D. Gai and J. A. Butman , NIH. T1 Error Analysis for Double Angle Technique and Comparison to Inversion Recovery b -SSFP Look-Locker Acquisition Looking at T1 error in DESPOT due to imperfect RF spoiling and B1 B1 correction not via DESPOT-HIFI

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ISMRM 2010

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  1. ISMRM 2010 Quantitative Imaging and MS

  2. N. D. Gai and J. A. Butman, NIH • T1 Error Analysis for Double Angle Technique and Comparison to Inversion Recovery b-SSFP Look-Locker Acquisition • Looking at T1 error inDESPOT due to imperfectRF spoiling and B1 • B1 correction not viaDESPOT-HIFI • DESPOT underestimatesT1 when TR/T1 ratio inc.from 0.01 to 0.1

  3. I. Vavasour and A.L. MacKay,University of British Columbia • Changes in Multiple Sclerosis Over 6 Months As Seen With T2 Relaxation and Diffusion Histograms • Measures of interest for 12 RR patients: • MWF – area under T2 dist from 0-40ms/total area • Geometric mean of T2 values • DTI • FA • MD/ADC • Diffusion eigenvalues • DTI changed over time, MWF did not -> they are measuring different aspects of the pathology • We can apply these techniques to our follow up scans for MSmcDESPOT but more quantitative characterization of histograms would be better • FLAIR used for both tissue and lesion segmentation

  4. I. Vavasour and A.L. MacKay,University of British Columbia

  5. C. Laule and A.L. MacKay,University of British Columbia • Myelin water fraction reduction in multiple sclerosis normal appearing white matter: Where are all the zeroes? • Anatomical distribution of MWF, is it globally homogenous or locally heterogeneous? • Improved sequence with better coverage and SNR at 3T for 3D multi echo T2 • 13 RR .94x1.88x5mm^3

  6. C. Laule and A.L. MacKay,University of British Columbia • Method • FSL segmentation, manual lesion seg. on FLAIR • Erosion of WM by 2 voxels to account for partial voluming • Spearman rank correlation coefficient as a non-parametric version of Pearson • We should use this • Results • Mean MWF negatively correlated with EDSS (R=-.57) • Female controls higher MWF than males • Zero value MWF (sort of a basic version of DV) • 10% vs 4.2% of total NAWM volume have MWF=0 for MS vs normal • This percentage correlates with EDSS R= 0.58 • 15% vs 9% in male vs female MS patients • Results similar to ROIs done at 1.5T and higher than another study at 3T

  7. C. Laule and A.L. MacKay,University of British Columbia • Zero value MWF is distributed throughout brain but tends to be at WM/GM interfaces

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