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Switch to ATV/r monotherapy - ATARITMO - Swedish Study - ACTG A5201 - OREY

Switch to ATV/r monotherapy - ATARITMO - Swedish Study - ACTG A5201 - OREY. ATARITMO Study: Switch to ATV/r monotherapy. Design. Open-label Single-arm Pilot trial. W24. HIV+ Conventional HAART > 6 months (stable during last 3 months) Or IDV/r monotherapy

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Switch to ATV/r monotherapy - ATARITMO - Swedish Study - ACTG A5201 - OREY

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  1. Switch to ATV/r monotherapy • - ATARITMO • - Swedish Study • - ACTG A5201 • - OREY

  2. ATARITMO Study: Switch to ATV/r monotherapy • Design Open-label Single-arm Pilot trial W24 HIV+ Conventional HAART > 6 months (stable during last 3 months) Or IDV/r monotherapy HIV-1 RNA < 50 c/mL > 3 months No history of treatment failure N = 30 * Adjusted to 400/100 mg qd based on drug monitoring at W4 • Primary endpoint • Confirmed virologic failure by W24 (2 consecutive HIV-1 RNA > 400 c/mL, or 3 consecutive HIV-1 RNA > 200 c/mL, or 4 consecutive HIV-1 RNA > 100 c/mL) Vernazza P, AIDS 2007;21:1309-15 ATARITMO

  3. ATARITMO Study: Switch to ATV/r monotherapy • Prior ARV therapy • Mean CD4 cell count at inclusion = 618/mm3 • 2 virologic failures (7%) • Among 20 patients with plasma HIV-RNA < 50 c/mL at W24, CSF HIV-1 RNA was > 100 c/mL in 3 • Conclusion • Limited pilot study, no control arm • Caution: risk of compartmentalisation of HIV RNA replication in the CSF Vernazza P, AIDS 2007;21:1309-15 ATARITMO

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