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Meningitis Outbreak Linked to Contaminated Steroid Compound

Meningitis Outbreak Linked to Contaminated Steroid Compound. Subtitle. Meningitis. Inflammation of meninges due to: Bacteria Viruses Fungi Parasites Cancer Drugs. Preservative-Free Methylprednisolone Acetate. Synthetic corticosteroid

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Meningitis Outbreak Linked to Contaminated Steroid Compound

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  1. Meningitis Outbreak Linked to Contaminated Steroid Compound Subtitle

  2. Meningitis • Inflammation of meninges due to: • Bacteria • Viruses • Fungi • Parasites • Cancer • Drugs

  3. Preservative-Free Methylprednisolone Acetate • Synthetic corticosteroid • Treatment for radicular pain from lumbar spine disorders • Lumbar epidural steroid injection • Depresses immune system

  4. Initial Case • Patient in Nashville, TN treated for meningitis for 2 weeks • CSF contained fungal cells from the genus Aspergillus

  5. Other Cases • 13 cases in Tennessee • 1 case in South Carolina • 2 deaths • All had received lumbar steroid injections • 700 administrations from original hospital • Traced back to compound pharmacy

  6. Problems • Fungal meningitis can cause strokes • Aspergillus difficult to grow in culture of CSF • Concern over safety of other steroid preparations • Incubation period of 1-4 weeks

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