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High Incidence of Long Bone Dysplasia In Newborn Infants In Qatar Post Gulf War

High Incidence of Long Bone Dysplasia In Newborn Infants In Qatar Post Gulf War. Y. Abu-Osba*; K. Salameh; S. Khan; M. Kayyali *Neonatal Medicine Services, Jordan Hospital, Amman, Jordan Neonatology Section, Women’s Hospital, Doha, Qatar.

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High Incidence of Long Bone Dysplasia In Newborn Infants In Qatar Post Gulf War

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  1. High Incidence of Long Bone Dysplasia In Newborn Infants In Qatar Post Gulf War Y. Abu-Osba*; K. Salameh; S. Khan; M. Kayyali *Neonatal Medicine Services, Jordan Hospital, Amman, Jordan Neonatology Section, Women’s Hospital, Doha, Qatar

  2. High Incidence of Long Bone Dysplasia In QatarEPIDEMIOLOGICAL AND CLINICAL CHARACTERISTICS Total No. of live birth baby 82.000 infants Qataris 47%Total NO. with long bone dysplasia 13(1.6/10,000) Qataris 69.2% (9/13)Female : male ratio 6/7Mean gestational age (SD) 37+3.1 wkLess than 37 wk. gestation 4/13Mean birth weight 2.610+749 g Mean head circumference 32.6 cmMean height 46.9 cm

  3. High Incidence of Long Bone Dysplasia In QatarMATERNAL FACTORS Mean maternal age 26.92 yearsNormal vaginal delivery 11/13 (84.6%)Parity 1.46 para /Mother Infants from multiple gestation 2 (15.3/10,000)

  4. High Incidence of Long Bone Dysplasia In QatarPREDISPOSING FACTORS Diabetes mellitus 6/ 13 53.8%History of abortion 5/ 13 38.5%History of consanguinity 7 /13 61.5%Mothers blood group O 10/13 76.9%History of drug intake 2/13 15.3%History of c. malformation 2/13 15.3%

  5. High Incidence of Long Bone Dysplasia In QatarTypes of Dysplasia - 1 • Total patientswithabsent / dysplastic long bones 13 • Absent - hypoplastic radius 9/13 • Absent – hypoplastic ulnae with or without radius 5/13 • Isolated long bone dysplasia 6/13 • ADLB with one or more associated anomalies 7/13

  6. High Incidence of Long Bone Dysplasia In QatarTypes of Dysplasia - 2 • Absent femur 1/13 • Dysplasia of tibia + fibulae 2/13 • Upper limb : Lower limb 3.3:1 • Left upper limb : Right upper limb 2.5:1 • Bilateral5/13

  7. High Incidence of Long Bone Dysplasia In QatarASSOCIATED MAJOR CONGENITAL ANOMALIS Associated with heart disease 5Associated with esophageal atresia 2Associated with hypoplastic kidney 2Associated with hydrocephalus 2Associated with sacral agenesis 2Associated with cleft lip + palate 1Absent radii associated with absent thumb 3/9Associated single umbilical artery 3

  8. High Incidence of Long Bone Dysplasia In QatarSUMMARY • Radius dysplasia incidence is 16: 100,000 compared to 1:100,000 in literature. • Associated with maternal diabetes 53.8 %. • Major multiple congenital anomalies are present in more than half of the cases. • Observed increase of three of folds the incidence of long bones dysplasia in the last 4 years (1990-1994) compared to the period of 1986-1989.

  9. High Incidence of Long Bone Dysplasia In QatarConclusion The incidence of long bones dysplasia in the newborns post the Gulf War increased by 4 folds in Qatar population compared to pre war period, and is much more common than the published literature . The cause is not clear yet ...!!! ???

  10. High Incidence of Long Bone Dysplasia In QatarRecommendations Further detailed epidemiological studies are recommended in the region to clarify the cause for these priliminary observations.

  11. Examples of Long Bone Aplasia / Dysplasia In Newborn Infants In Qatar

  12. Examples of Long Bone Aplasia / Dysplasia In Newborn Infants In Qatar

  13. Examples of Long Bone Aplasia / Dysplasia In Newborn Infants In Qatar

  14. Examples of Long Bone Aplasia / Dysplasia In Newborn Infants In Qatar

  15. Examples of Long Bone Aplasia / Dysplasia In Newborn Infants In Qatar

  16. Examples of Long Bone Aplasia / Dysplasia In Newborn Infants In Qatar

  17. Examples of Long Bone Aplasia / Dysplasia In Newborn Infants In Qatar

  18. Examples of Long Bone Aplasia / Dysplasia In Newborn Infants In Qatar

  19. Examples of Long Bone Aplasia / Dysplasia In Newborn Infants In Qatar

  20. Examples of Long Bone Aplasia / Dysplasia In Newborn Infants In Qatar

  21. Examples of Long Bone Aplasia / Dysplasia In Newborn Infants In Qatar

  22. Examples of Long Bone Aplasia / Dysplasia In Newborn Infants In Qatar

  23. Examples of Long Bone Aplasia / Dysplasia In Newborn Infants In Qatar

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