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Organophosphates and Enzymes

Organophosphates and Enzymes. Vocabulary to Know: Review. Neuron : A cell that transmits electrical or chemical signals in the body Neurotransmitter : A chemical that sends a signal from one neuron to another Synapse : The connection between neurons where neurotransmitters pass. .

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Organophosphates and Enzymes

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  1. Organophosphates and Enzymes

  2. Vocabulary to Know: Review • Neuron: A cell that transmits electrical or chemical signals in the body • Neurotransmitter: A chemical that sends a signal from one neuron to another • Synapse: The connection between neurons where neurotransmitters pass.

  3. Acetylcholine and Acetylcholinesterase • Acetylcholine: A neurotransmitter involved in transmission of signals that regulate muscle stimulation, learning and memory. • Acetylcholinesterase: An enzyme that degrades acetylcholine (substrate). • Why might this be important?

  4. Organophosphate and Enzymes Video

  5. Here’s The Problem • Integumentary System

  6. Here’s The Problem • Circulatory System

  7. Here’s The Problem • Nervous System: Organophosphates enter the brain and inhibit acetylcholinesterase.

  8. Nervous System • With organophosphates around, acetylcholine builds up in the nervous system (parasympathetic and sympathetic) • The build up in the parasympathetic causes the most symptoms. • Bad things happen. • SLUDGE: Overstimulation at the orifices. • Increased saliva, tears, urination, defecation, gastrointestinal problems and vomiting Acetylcholine

  9. Other Non-Competitive Inhibitors • Alzheimer’s disease drugs work this way too. • They “stop up” acetylcholinesterase in order to prevent the breakdown of acetylcholine. This is important for thinking and memory.

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