1 / 6

Breakout Group C

Breakout Group C. Jennifer Seed (Chairwoman), Allison Jenkins ( Rapporteur ), Janet Kester, Daniele Staskal, Gulan Sun, Valerie Meyers (phone), Andy Maier (phone), Bob Budinsky (phone), Ted Simon (phone). Case Study Proposal #8.

kimball
Download Presentation

Breakout Group C

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Breakout Group C Jennifer Seed (Chairwoman), Allison Jenkins (Rapporteur ), Janet Kester, Daniele Staskal, Gulan Sun, Valerie Meyers (phone), Andy Maier (phone), Bob Budinsky (phone), Ted Simon (phone)

  2. Case Study Proposal #8 • Exploring three conceptual models for individual/population dose response using 2,3,7,8-trachlorodibenzodioxin (TCDD) as an example. TCDD is data-rich and would permit exploration of all three models. • Ted Simon, Bob Budinsky, J. Craig Rowlands • Very well described, draft proposal completed • Existing publication (Simon 2009) and Simon et al. (unpublished)

  3. Case Study Proposal #20 • #20 – Three nuclear receptors, AHR, CAR/PXR and PPARα, will be used as examples for how their biology can be used to define mode of action and dose-response for liver tumors in rodents. • Teams are in the process of developing case studies for September 2010 Nuclear Receptor Workshop • Breakout Group C proposes to link case study proposals #20 (general) and #8 (specific example) • #20 (or similar) will be prepared for September 2010 Nuclear Receptor Workshop.

  4. Case Study Proposals #6, #25 • Screening proposals • Easily Accomplished • Recommend problem formulations are expanded in both case study proposals

  5. Case Study Proposal #15 • Ongoing chromium MOA study to address data gaps in the knowledge of its mode of action. • Data will not be completed by date of 2nd ARA Workshop • Breakout Group C proposes to ‘table’ Proposal #15 for consideration at ARA Workshop 2

  6. Idea for Case Study • DNA damage by intracellularly generated formaldehyde has been proposed as a carcinogenic mode of action for several chemicals (e.g., methanol, MTBE). • Data on formaldehyde-DNA adduct formation can be used to evaluate this hypothesis. • Unknown if sufficient data exist. • Janet Kester is contact person.

More Related