1 / 3

Intra-cranial self-stimulation (ICSS) Olds & Milner (1954) Delgado (1954)

Intra-cranial self-stimulation (ICSS) Olds & Milner (1954) Delgado (1954) Olds (1955) - hedonic theory Deutsch (1962) – 2-factor decay theory Idiosyncrasies: a) priming b) no satiation c) fast extinction d) intermittent (partial) reinforcement

konane
Download Presentation

Intra-cranial self-stimulation (ICSS) Olds & Milner (1954) Delgado (1954)

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Intra-cranial self-stimulation (ICSS) Olds & Milner (1954) Delgado (1954) Olds (1955) - hedonic theory Deutsch (1962) – 2-factor decay theory Idiosyncrasies: a) priming b) no satiation c) fast extinction d) intermittent (partial) reinforcement Gallistel (1967) – “paired-pulse” technique Start Runway Goal “priming stimulus” “reward stimulus” Refractory periods: 0.5 - 0.6 msec » “prime” 0.8 - 1.1 msec » reward

  2. ICSS Stein (1962) - Mj. tranquilizers - e.g., chlorpromazine (inhibit ICSS) Amphetamine - facilitates ICSS ICSS - thresholds Catecholamines: DA, NE Depression, Mania Crow (1972) - DA agonists, antagonists, 6-Hydroxydopamine Mesocorticolimbic DA system (MFB) Ventral Tegmental Area (VTA) » N. Accumbens, limbic, prefront. Gibson et al. (1975) – procedural artifact Gallistel (1967) - 2 types of fibers ~ 0.5 + 1.0 msec Shizgal (1989) : small N. Accumbens VTA Glutamate large, myelinated DA ?

  3. ICSS Rolls (1980) - Single units: Sensory (incentive) Drive Reinforcement Delgado (1978) - ICSS in Humans spontaneous pleasure, sexual, mood changes, pain relief, drive reduction Stein & Belluzzi (1990) - DA + Enkephalins / endorphins - addiction (separate or co-localized?) Henry (1990) - ICSS & Sex, Pain, Jogging Endogenous opiates + stress; Naloxone, Naltrexone S SRe D Video: The Addicted Brain

More Related