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History. Early 1900's Alexis Carrel1950's Jacobsen and Suarez
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1. Microvascular Free Tissue Transfer Glen T. Porter, MD
Shawn D. Newlands, MD
UTMB-Galveston, TX
October 2004
2. History Early 1900’s Alexis Carrel
1950’s Jacobsen and Suarez—anastomoses in animals
1959 Seidenberg– free jejunum segments to repair pharyngoesophageal defects (human)
1972 McLean and Buncke – omental flap to cover a cranial defect (first “microvascular” flap)
1973 Daniels and Taylor– “free flap”
First free cutaneous flap
1976 Baker and Panje– first free flap in head and neck cancer reconstruction
Groin flap pedicled on the circumflex iliac artery
3. Advantages of free tissue transfer Two team approach
Improved vascularity and wound healing
Low rate of resorption
Defect size of little consequence
Potential for sensory and motor innervation
Permits use of osseointegrated implants
4. Advantages of free tissue transfer Wide variety of available tissue types
Large amount of composite tissue
Tailored to match defect
Wide range of skin characteristics
More efficient use of harvested tissue
Immediate reconstruction
5. Recipient vessels Arteries
Superficial temporal system –scalp and upper face
Facial artery—midface and cervical region (atherosclerosis common)
Superior thyroid or lingual artery—lower cervical region
Other: thyrocervical trunk, external carotid, common carotid
6. Recipient vessels Veins
External jugular
Branches of internal jugular (common facial)
Internal jugular
Retrograde (superficial temporal, thyroid)
Transverse cervical, occipital (very small)
7. Recipient vessels after previous neck dissection Gold standard: Angiogram (short-term injury to endothelium reported)
Operative reports
Long-pedicled flaps
Thyrocervical trunk (transverse cervical), Occipital vessels, retrograde drainage (thyroid veins, superficial temporal), external carotid artery
Contralateral vessels (recipient or graft)
End-to-side anastomoses with large vessels
Vein grafts
Arteriovenous loop (poorer results)
8. Vessel selection Size
Arterial vs.Venous
Atherosclerosis
XRT-related changes
Vessel geometry (location and orientation)
Vessel length
9. Vessel preparation Arteries need to have strong pulsatile flow—cut until it flows.
Cut back beyond branches or ligate them if sufficiently distant from the anastomosis site.
Atherosclerosis
Intimal inspection
Dilation
Removing the adventitia
10. Irradiated vessels Technically more difficult—effects appear specific to arteries
Higher incidence of atherosclerosis
Vessel wall fibrosis, increased wall thickness, more intimal dehiscence
No reported difference in outcome of microvascular anastomoses (Nahabedian MY, et al., 2004, Kroll SS, et al 1998)
Microvascular anastomoses tolerate XRT well long-term (Foote RL., et al., 1994)
Require careful handling, cut off clot (teasing thrombi may denude vessel wall—”sticky” walls), smaller suture, needle introduced from lumen to outside wall (to pin intima to wall)
11. Prepare vessels
Evaluate vessel geometry
Trim, irrigate, dilate
Partial flap insetting (bony cuts and plating done at donor bed, if necessary)
Arterial vs. venous anastomosis first with early or delayed unclamping of first vessel showed no difference. (Braun, et al., 2003)
Anastomosis of remaining vessel
Complete flap insetting Microvascular Anastomosis
12. Microvascular surgical technique Trim adventitia
2-3mm
Gentle handling (no full-thickness)
Trim free edge, if needed
Dissect vessels from surrounding tissues
Irrigate and dilate
Heparinized saline
Mechanical dilation (1 ˝ times normal –paralyses smooth muscle)
Chemical dilation, if necessary
Suturing
13. Microvascular suture technique 3 guide sutures (120 degrees apart)
Perpendicular piercing
Entry point 2x thickness of vessel from cut end
Equal bites on either side
Microforceps in lumen vs. retracting adventitia
Pull needle through in circular motion
Surgeon’s knot with guide sutures, simple for others
Avoid backwalling—2 bites/irrigation
14. 3 suture technique
15. Vessel size mismatch Laminar flow vs. turbulent flow
<2:1 – dilation, suture technique
>2:1, <3:1 – beveling or spatulation (no more than 30 degrees to avoid turbulence)
>3:1 – end-to-side
16. End-to-end vs. End-to-side Recent reports indicate end-to-side without increase in flap loss or blood flow rate.
End-to-side overcomes size discrepancy, avoids vessel retraction, and IJ may act as venous siphon.
End-to-side felt best when angle is less than 60 degrees (minimize turbulence)
Vessel incision should be elliptical, not slit
Can use continuous suture technique
17. End-to-side Anastomosis
18. Continuous suture technique May significantly narrow anastomosis
May be used on vessels >2.5 mm
Decreases anastomosis time by up to 50%
Decreases anastomosis leakage
Most commonly used for end-to-side anastomoses with large vessels
19. Mechanical anastomosis Devices
Clips
Coupler
Laser
Results
Increased efficiency and speed, use in difficult areas
Patency rates at least equal to hand-sewn (Shindo, et al 1996, De Lorenzi, et al 2002)
Can be used for end-to-end or end-to-side (DeLacure, et al 1999)
Poorer outcome with arterial anastomosis—20-25% failure (Shindo, et al 1996, Ahn, et al 1994)
20. Vein grafts Used in situation where pedicle is not long enough for tension-free anastomosis
Usually harvested from lower extremity (saphenous system)
Valve orientation is necessary
Avoid anastomosis at level of vein valve
Keep clamps in place until both anastomoses sewn
Prognosis for success controversial (Jones NF, et al., 1996, German, et al. 1996)
Recent literature 30% failure (vs. 5%) in 1993 study, German 1996 showed no difference, but revisions greater in vein graft cases (15% vs. 9%)30% failure (vs. 5%) in 1993 study, German 1996 showed no difference, but revisions greater in vein graft cases (15% vs. 9%)
21. Microvascular Hints & Helps Use background to help visualize suture
Demagnetize instruments, if needed
May reclamp vessels for repair after 15 minutes of flow
Reclamp both arterial and venous vessels when revising venous anastomosis
Support your hands and hold instruments like a pencil
22. Ischemia Primary and secondary
Primary: 2.25-6 hours
Secondary: 1-12 hours
Interrelation
No flow phenomenon
Cold vs. normothermic
In vitro studies show benefit to cooling of flaps
In vivo studies show surface cooling (<4hr ischemia time) does not adversely effect flap success (Shaw W. et al 1996)
Tissue specific critical ischemia times
Metobolic rate dependent
Perfusates (UW, tissusol, Viaspan, Heparin)
Literature unclear
23. Anastomotic failure
93-95% success rate expected
Venous thrombosis:Arterial thrombosis 4:1, ateriovenous loop, tobacco use significant factors (Nahabedian M., et al, 2004) Other literature indicates 9/10 thromboses secondary to venous thrombus
Tobacco use as contribution controversial (4/5 failures in Nahabedian study - venous thrombosis)
Venous occlusion, Delayed reconstruction, Hematoma significant factors in breast free tissue recon. (Nahabedian M., et al, 2004)
Salvage 50% in breast reconstruction
Age, prior irradiation, DM (well-controlled), method of anastomosis, timing, vein graft, and specific arteries/veins not felt to contribute to failure rate
24. Anastomotic Failure--timeline 15-20 minutes
<72 hours
5-7 days
>8 days
Thin vs. thick flaps
25. Thrombus formation Injury to endothelium and media of vessel
Mechanical vs. thermal
Error in suture placement
Backwall or loose sutures
Edges not well-aligned (most common in veins—most common site of thrombus)
Intimal discontinuity with exposure of media
Oblique sutures, large needles, tight knots
Infection
Hypovolemia and low flow states
Nitroprusside at dose to decrease arterial pressure by 30% causes severe reduction in flap blood flow (40%) (Banic, et al. 2003)
Vessel geometry (kinking, tension)
26. Vessel spasm Causes
Trauma
Contact with blood
Vasoconstrictive drugs
Phenylephrine--dose causing 30% increase in arterial pressure shows no effect on flap circulation (Banic A, et al., 1999)
Nicotine
Temperature, drying
Treatment
Warmth
Xylocaine
Papavarine, thorazine
Volume repletion
27. Treatement for anastomotic failure Revision of anastomoses
Exploration of wound
Streptokinase, urokinase, rt-PA (Atiyeh BS, et al 1999)
Leech therapy
Wound care
Statistics
Revisions successful in 50%
Revisions less successful after first 24-48hr
>6 hrs of ischemia leads to poor survival
12 hrs of ischemia leads to “no-flow” phenomenon
After 5 days almost all flaps in rabbit model survived with loss of artery or vein (but not both)—this is rational for other modalities after 48 hours
28. Post-operative care Anticoagulation
Attention to wound care
Flap monitoring
Nothing around neck that might compress pedicle
Antibiotics
Hemoglobin/intravascular volume—literature unclear (Velanovich V., et al 1988, Quinlan 2003)
No pressors/nicotine/cooling of flap (literature unclear)
29. Anticoagulation Rheology
RBC concentration
Plasma viscosity
RBC aggregation
RBC deformability
Other (platelets, thrombogenic mediators)
Agents
Aspirin
Heparin
Dextran
Other
Indications
Hypercoagulable state (Friedman G, et al, 2001)
Excessive vessel trauma
Complications
30. Dextran Macromolecule which is a compound of glucose subunit
Thought to improve RBC flexibility, increase electronegativity of vessel wall (which decreases platelet adhesion), act as intravascular volume expander, decrease RBC aggregation
Shown to decrease clotting secondary to exposed collagen in rabbit arteries. Little effect on platelet, rather inhibits fibrin stabilization of thrombi (Weislander, JB, et al., 1986)
No effect on overall flap survival when compared with aspirin. Systemic complications 3.9-7.2 times more common with dextran infusion (Disa J., et al, 2001)
Complications can include renal damage, anaphylactic shock, congestive heart failure, MI, pulmonary edema, pleural effusion, pneumonia
31. Aspirin Prevent platelet thrombosis
Inhibits arachidonic acid to prostaglandin synthesis on the platelet—prevents release of platelet granuoles that cause platelet aggregation. Mechanism is biphasic and dose-dependant
High doses of aspirin can have negative effect on endothelial production of prostacyclin which prevents platelet accumulation on exposed collagen and dilates vessels.
ASA PR qd x several weeks (often given at beginning of case)—5 grains (325 mg)
No good studies to confirm benefit of use
Hematoma formation
32. Heparin Naturally occuring glycosoaminoglycan which interrupts clotting cascade
Prevents transformation of prothrombin to thrombin, fibrinogen to fibrin
Does not lyse existing thrombi
Strongly adheres to endothelium
Concentration on endothelium 100x serum
˝ life = 90 minutes
Given at time of first quarter of arterial anastomoses vs. at time of unclamping (bolus only vs. bolus with drip x 3 days)
Literature unconvincing, although it may increase microvascular perfusion after ischemia
Hematoma formation
Used as irrigation solution
Local infusion may possibly be beneficial
33. Low molecular weight heparin Appears to decrease vessel thrombosis in renal transplants (Broyer M, et al.,1991, Alkhunaizi AM, et al, 1998)
34. Flap monitoring Clinical –”flap checks”
Most commonly used
Warmth
Color
Pin prick
Wound monitoring (hematoma, fistula)
Frequency
Mechanical
Doppler
Implanted vs. external vs. color flow
Other
35. Clinical flap monitoring Normal exam:
Warm, good color, CRT 2-3 seconds, pinprick slightly delayed with bright red blood
Venous occlusion (delayed):
Edema, mottled/purple/petechiae, tense
CRT decreased
Pinprick – immediate dark blood, won’t stop
Arterial occlusion (usually <72hr):
Prolonged CRT, temperature, turgor
Pale
Pinprick—little bleeding, very delayed
36. Mechanical flap monitoring Doppler
External
Implanted
Buried flaps
80-100% salvage (Disa J, et al 1999)
Color flow
Other
37. Antibiotics 8-20% of patients undergoing free tissue transfer will develop an infection despite intravenous antibiotic coverage.(Cloke DJ., et al, 2004)
1 day vs. 5 day course of Clindamycin showed no significant difference in free flap survival (Carroll WR., et al., 2003)
Topical antibiotics in combination with intervenous antibiotics did not show a significant difference in post-operative complications after free tissue transfer (Simons JP, et al., 2001)
38. Free flap reconstruction—the costs Longer ICU stay, more expensive, longer OR time (McCrory AL, et al., 2002)
44. Sources Broyer M, Gagnadoux MF, Sierro A, Fischer AM, Niaudet P. Preventive treatment of vascular thrombosis after kidney transplantation in children with low molecular weight heparin. Transplant Proc 1991; 23: 1384.
Alkhunaizi AM, Olyaei AJ, Barry JM, et al. Efficacy and safety of low molecular weight heparin in renal transplantation. Transplantation 1998; 66: 533.
Nahabedian MY. Singh N. Deune EG. Silverman R. Tufaro AP. Recipient vessel analysis for microvascular reconstruction of the head and neck. [Journal Article] Annals of Plastic Surgery. 52(2):148-55; discussion 156-7, 2004 Feb.
McCrory AL. Magnuson JS. Free tissue transfer versus pedicled flap in head and neck reconstruction. [Journal Article] Laryngoscope. 112(12):2161-5, 2002 Dec.
Kroll SS. Robb GL. Reece GP. Miller MJ. Evans GR. Baldwin BJ. Wang B. Schusterman MA. Does prior irradiation increase the risk of total or partial free-flap loss?. [Journal Article] Journal of Reconstructive Microsurgery. 14(4):263-8, 1998 May.
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Cloke DJ. Green JE. Khan AL. Hodgkinson PD. McLean NR. Factors influencing the development of wound infection following free-flap reconstruction for intra-oral cancer. [Journal Article] British Journal of Plastic Surgery. 57(6):556-60, 2004 Sep.
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Banic A. Krejci V. Erni D., et al. Effects of sodium nitroprusside and phenylephrine on blood flow in free musculocutaneous flaps during general anesthesia. Anesthesiology 90(1):147-155, 1999
German G. Steinau HU. The clinical reliability of vein grafts in free flap transfer. Journal of Reconstructive Surgery 67:194-199, 1996
Nahabedian MY. Bahram M. Manson PN. Factors associated with anastomotic failure after microvascular reconstruction of the breast. Plastic and Reconstructive Surgery 114(1):74-82, 2004
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Carroll WR. Rosenstiel D. Fix JR. de la Torre J. Solomon JS. Brodish B. Rosenthal EL. Heinz T. Niwas S. Peters GE. Three-dose vs extended-course clindamycin prophylaxis for free-flap reconstruction of the head and neck. [Clinical Trial. Journal Article. Randomized Controlled Trial] Archives of Otolaryngology -- Head & Neck Surgery. 129(7):771-4, 2003 Jul.
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