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Patient D.C. Laparoscopic Renal Cryoablation

Patient D.C. Laparoscopic Renal Cryoablation. Indications. Renal tumors < 4cm Peripheral or Exophytic Separate from the collecting system Bilateral synchronous tumors Solitary kidney or compromised renal function. Mechanism of Tissue Injury. Immediate Direct effect of freezing the cells

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Patient D.C. Laparoscopic Renal Cryoablation

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  1. Patient D.C.Laparoscopic Renal Cryoablation

  2. Indications • Renal tumors < 4cm • Peripheral or Exophytic • Separate from the collecting system • Bilateral synchronous tumors • Solitary kidney or compromised renal function

  3. Mechanism of Tissue Injury • Immediate • Direct effect of freezing the cells • Delayed • vascular insufficiency and destruction of tissue • coagulative necrosis

  4. Freezing • Ice forms in the extracellular compartment • This draws fluid out of the cell causing chemical damage to the cell • Crystals form in the intracellular space

  5. Thawing • Re-crystallization & fusion of smaller crystals (severe damage) • Vasoconstriction & halt in circulation during freeze • porous endothelium • edema • platelet aggregation • thrombosis and ischemia

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