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Understanding Uric Acid: Symptoms, Causes, and Management

Uric acid is a byproduct of purine metabolism that can lead to conditions like gout when levels are high. Symptoms include intense joint pain and inflammation. Managing uric acid levels involves dietary changes, staying hydrated, and maintaining a healthy weight. Testing uric acid levels is important for diagnosing conditions like gout and monitoring kidney function or treatment effectiveness.

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Understanding Uric Acid: Symptoms, Causes, and Management

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  1. Uric acid Uric acid M.s.c. Huda Raad Karim M.s.c. Huda Raad Karim

  2. Introduction Introduction Uric breakdown of nucleic acids and is an end product of purine metabolism. Uric acid is transported by the blood from the liver to the kidney, where it is filtered. Renal excretion accounts for 75% of uric acid elimination; the remainder of uric acid passes into the GI tract. acid is formed from the

  3. Symptoms Symptoms  Intense joint pain. Gout usually affects the big toe, but it can occur in any joint. ...  Lingering discomfort. After the most severe pain subsides, some joint discomfort may last from a few days to a few weeks. ...  Inflammation and redness. ...  Limited range of motion.

  4. Normal range Normal range In human blood plasma  Female: 2.6-6.0 mg/dl (155-357 µmol/L)  Male: 3.5-7.2 mg/dl (208-428 µmol/L)  Child: 2.0-5.5 mg/dl (119-327 µmol/L)

  5. Natural Ways to Reduce Uric Acid in the Body Natural Ways to Reduce Uric Acid in the Body  Limit purine-rich foods  Avoid sugar  Drink more water  Avoid alcohol  Drink coffee  Manage weight  Manage blood sugar  Add more fiber to your diet  Boost vitamin C intake  Eat cherries and Check your medications and supplements

  6. Hyperurecemia Hyperurecemia Causes of hyperurecemia Urate Pool High intake of dietary purine Hereditary reasons Reduced excretion by kidney Drugs e.g. thiazide diuretics Fasting or rapid weight loss can temporary elevate uric acid level

  7. Hypourecemia Hypourecemia  is less common than hyperuricemia and is usually secondary to severe liver disease or defective tubular reabsorption, as in Fanconi syndrome.

  8. Clinical significance Clinical significance Disease states with increased plasma uric acid  Gout (increased serum levels of uric acid lead to formation of monosodium urate crystals around the joints)  Increased catabolism of nucleic acids  Renal disease

  9. Why it is done Why it is done Uric acid test is useful to  Assess for gout  Monitor patients with renal failure and see if kidney stone may be caused by high uric acid level  Monitor if uric acid levels are too high after chemotherapy or radiation  See if medicine that decreases uric acid level is working

  10. Thank you

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