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1. PH402 Hypertension and Antihypertensives Chris Hague, PhD
chague@u.washington.edu
Technical Advisor: Seth Goldenberg, PhD
2. Brody’s Human Pharmacology, 4th Edition
Guyton Human Physiology
http://www.americanheart.org/presenter.jhtml?identifier=2152
http://www.nhlbi.nih.gov/health/dci/Diseases/Hbp/HBP_WhatIs.html References
10. 42,418 participants
Findings: Chlorthalidone is superior to an ACE inhibitor, a calcium channel blocker and an alpha1-adrenergic antagonist in preventing one or more CVD events.
Recommendations for antihypertensive treatment:
Use Thiazide-type diuretics as first treatment in stage I and II hypertension
prevent cardiovascular disease better than other classes
lower cost
drugs of choice for first-step antihypertensive therapy.
Diuretic intolerant patients: consider Ca2+ channel blockers and ACE inhibitors
Most hypertensive patients require more than one drug. Diuretics should generally be part of the antihypertensive regimen.
Lifestyle advice should also be provided.
http://www.nhlbi.nih.gov/health/allhat/index.htm