1 / 50

DRUGS FOR THE TREATMENT OF DIABETES MELLITUS

2. DIABETES MELLITUS. Affects approx. 5

louis
Download Presentation

DRUGS FOR THE TREATMENT OF DIABETES MELLITUS

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

    1. 1 DRUGS FOR THE TREATMENT OF DIABETES MELLITUS

    2. 2 DIABETES MELLITUS Affects approx. 5 – 8 % Mostly asymptomatic Tendency increase with obesity One of the leading cause of death by disease One of the leading cause of blindness One of the leading cause of renal failure

    3. 3

    4. 4 EFFECTS OF INSULIN CARBOHYDRATES

    5. 5 INSULIN DEFICIENCY – DIABETES MELLITUS GLUCOSE UPTAKE HYPERGLYCEMIA GLYCOSURIA DEHYDRATION,

    6. 6 Insulin Degradation Hydrolysis of the disulfide linkage between A&B chains. 60% liver, 40% kidney(endogenous insulin) 60% kidney,40% liver (exogenous insulin) Half-Life 5-7min (endogenous insulin) Delayed-release form( injected one) Category B ( not teratogenic) Usual places for injection: upper arm, front& side parts of the thighs& the abdomen. Not to inject in the same place ( rotate) Should be stored in refrigerator& warm up to room temp before use. Must be used within 30 days.

    7. 7

    8. 8

    9. 9

    10. 10

    11. 11

    12. 12

    13. 13

    14. 14

    15. 15

    16. 16 Methods of Adminisration Insulin Syringes Pre-filled insulin pens External insulin pump Under Clinical Trials Oral tablets Inhaled aerosol Intranasal, Transdermal Insulin Jet injectors Ultrasound pulses

    17. 17

    18. 18

    19. 19

    20. 20 Oral Hypoglycemics All taken orally in the form of tablets. Pts with type11 diabetes have two physiological defects: Abnormal insulin secretion Resistance to insulin action in target tissues associated with decreased number of insulin receptors

    21. 21

    22. 22

    23. 23

    24. 24

    25. 25

    26. 26

    27. 27

    28. 28

    29. 29

    30. 30

    31. 31

    32. 32

    33. 33

    34. 34

    35. 35

    36. 36

    37. 37 Advantages of Metformin over SUs Does not cause hypoglycemia ( why ? ) Does not result in wt gain ( why ? ) ( Ideal for obese pts )

    38. 38

    39. 39

    40. 40

    41. 41

    42. 42

    43. 43

    44. 44

    45. 45

    46. 46

    47. 47

    48. 48

    49. 49

    50. 50

    51. 51

More Related