1 / 34

SPUC December 15, 2008 Francisco.LaRosa@UCDenver

SPUC December 15, 2008 Francisco.LaRosa@UCDenver.edu. CASE 1. CASE 1 Diagnosis: Coccidioidomycosis. Coccidioidomycosis. Diagnosis Coccidioidomycosis - Endemic fungal infection of the desert southwestern United States - Generally a self-limited illness in healthy persons.

malise
Download Presentation

SPUC December 15, 2008 Francisco.LaRosa@UCDenver

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. SPUC December 15, 2008 Francisco.LaRosa@UCDenver.edu

  2. CASE 1

  3. CASE 1 Diagnosis: Coccidioidomycosis

  4. Coccidioidomycosis

  5. Diagnosis Coccidioidomycosis - Endemic fungal infection of the desert southwestern United States - Generally a self-limited illness in healthy persons. - Immunosuppressed persons who contract it are at increased risk for disseminated infection Janis E. Blair, MD; Jerry D. Smilack, MD; Sean M. Caples, DO. Coccidioidomycosis in Patients With Hematologic Malignancies Arch Intern Med. 2005;165:113-117

  6. Histoplasmosis

  7. Cryptococcosis

  8. CASE 2

  9. Case 2 Diagnosis: Leiomyoma

  10. Mesenchymal tumors of the gastrointestinal tract are less frequent than epithelial neoplasms but they are by no means rare. • Gastrointestinal stromal tumors (GISTs): • Most common mesenchymal tumor of the GI tract • Histopathology: • cellular spindled • epithelioid • pleomorphic lesions • express KIT (CD117) and CD34 proteins

  11. True leiomyomas of the muscularis propria: • Common in the esophagus and rare in the gastric body and antrum • Most frequent mesenchymal tumor of the esophagus: • Leiomyomas outnumber GIST by a ratio of 3 to 1

  12. CASE 3

  13. Case 3 Diagnosis: Thymoma AB

  14. Thymoma Type B1

  15. CLASSIFICATION OF THYMOMAS

  16. CASE 4

  17. Case 4 Diagnosis: Giant Cell Tumor of Tendon Sheet

  18. CASE 5

  19. Case 5 Diagnosis: Fibrous Dysplasia

  20. Fibrous dysplasia, benignt tumor (developmental arrest) Components of normal bone are present, but they fail to differentiate into mature structures. Occurs as one of three clinical patterns: 1. involvement of a single bone (monostotic) 2. involvement of multiple bones( polyostotic) 3. Polyostotic disease, associated with cafe au lait skin pigmentations and endocrine abnormalities, precocious puberty (McCune- Albright syndrome). Somatic, not hereditary. Skeletal, skin, and endocrine lesions from G protein that constitutively activates adenyl cyclase with resultant cyclic adenosin monophosphate overproduction and cellular hyperfunctioning.

  21. CASE 6

  22. Case 5 Diagnosis: Chemical / Reactive Gastropathy

  23. CHRONIC, REACTIVE (CHEMICAL) GASTROPATHY • - Very common in current clinical practice. • Changes usually more prominent in the prepyloric region • The usual underlying causes include chronic bile reflux and long-term NSAID intake.

  24. CHRONIC, REACTIVE (CHEMICAL) GASTROPATHY • The histopathologic features: • mucosal edema • congestion • fibromuscular hyperplasia in the lamina propria • foveolar hyperplasia with a corkscrew appearance in the most severe forms • The foveolar epithelium characteristically: reactive nuclear features and reduction of mucin. • The epithelial changes occur with little background chronic inflammation. Arch Pathol Lab Med—Vol 132, October 2008

More Related