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Chapter 12 (part 1)

Chapter 12 (part 1). Citric Acid Cycle. Gylcolysis. Electron Transport and Oxidative phosphorylation. TCA Cycle. Entry into the TCA Cycle. Pyruvate Dehydrogenase. Citrate Synthase. Only step in TCA cycle that involves the formation of a C-C bond. Aconitase. Isocitrate Dehydrogenase.

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Chapter 12 (part 1)

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  1. Chapter 12 (part 1) Citric Acid Cycle

  2. Gylcolysis Electron Transport and Oxidative phosphorylation TCA Cycle

  3. Entry into the TCA Cycle

  4. Pyruvate Dehydrogenase

  5. Citrate Synthase • Only step in TCA cycle that involves the formation of a C-C bond

  6. Aconitase

  7. Isocitrate Dehydrogenase

  8.  -Ketoglutarate Dehydrogenase

  9. Succinyl-CoA Synthetase

  10. Fumarase

  11. Malate Dehydrogenase

  12. Reduced Coenzymes Fuel ATP Production • Acetyl-CoA + 3 NAD+ + Q + GDP + Pi +2 H20  HS-CoA + 3NADH + QH2 + GTP + 2 CO2 + 2 H+ • Isocitrate Dehydrogenase 1 NADH=2.5 ATP • a-ketoglutarate dehydrogenase 1 NADH=2.5 ATP • Succinyl-CoA synthetase 1 GTP=1 ATP • Sunccinate dehydrogenase 1 QH2=1.5 ATP • Malate Dehydrogenase 1 NADH=2.5 ATP • Total of 10 ATPs gained from oxidation of 1 Acetyl-CoA

  13. Regulation of TCA Cycle

  14. Protein/amino acid Catabolites feed Into the TCA Cycle

  15. Fats breakdown and feed into the TCA Cycle

  16. TCA Cycle provides intermediates for many biosynthetic processes

  17. The Anaplerotic Reactions • The "filling up" reactions • PEP carboxylase - converts PEP to oxaloacetate • Pyruvate carboxylase - converts pyruvate to oxaloacetate • Malic enzyme converts pyruvate into malate

  18. Following the carbons through the TCA cycle

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