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Possible papers for discussion: Huberman et al., 2006 Neuron Crair et al., 1998 Science

Neurobiology of Cortical Systems Cortical Development and Plasticity Michael Crair Lecture 5. Possible papers for discussion: Huberman et al., 2006 Neuron Crair et al., 1998 Science Crowley and Katz, 2000. Retinocortical pathway. OD pathway. Lateral Geniculate Nucleus (LGN). I-III.

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Possible papers for discussion: Huberman et al., 2006 Neuron Crair et al., 1998 Science

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  1. Neurobiology of Cortical Systems Cortical Development and Plasticity Michael Crair Lecture 5 Possible papers for discussion: Huberman et al., 2006 Neuron Crair et al., 1998 Science Crowley and Katz, 2000

  2. Retinocortical pathway

  3. OD pathway Lateral Geniculate Nucleus (LGN) I-III IV V-VI Primary Visual Cortex (Striate Cortex or V1 or Area 17)

  4. Visual Maps Tootell, 1988Tootel et al.

  5. Transneuronal Labeling

  6. LGN lamina

  7. OD Columns

  8. Ocular dominance columns Adams et al., 2007

  9. Ocular dominance column plasticity active eye normal eye deprived eye Hubel and Wiesel, 1978

  10. Critical Periods in Development

  11. Critical Periods in Development

  12. Ocular Dominance Column Plasticity Neonate or Adult treated with with TTX as Neonate Normal Adult Cortex L Eye (blue) Monocularly Deprived Strabismic Cortex

  13. ‘Reverse Plasticity’ ‘Reverse Plasticity’ as a result of monocular deprivation while cortex is inhibited Treated Hemisphere (muscimol) Control Hemisphere Closed eye afferents are labeled Hata and Stryker, Science, 265:1732-1735, 1994

  14. ‘Reverse Plasticity’ Hataet al., Science 1994 Hataet al., Neuron 1999

  15. Hebb’s Postulate of Learning: Activity dependent changes in synaptic function underly CNS phenomena such as learning and memory. “When an axon of cell A is near enough to excite a cell B and repeatedly and persistently takes part in firing it, some growth or metabolic change takes place in one or both cells such that A’s efficiency, as one of the cells firing B, is increased.” -or- “Cells that fire together wire together.”

  16. Hebb’s Rule

  17. Classic model for OD development

  18. On-off schematic Development of Orientation Selectivity

  19. Orientation selective cell

  20. Lample, Anderson, Gillespie and Ferster, 2001

  21. Maps in the visual system Blasdel and Salama, Nature (1986)

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