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Iowa gambling task (rats) anxiety and the medial prefrontal cortex

Iowa gambling task (rats) anxiety and the medial prefrontal cortex. de Visser, Baars , van t’ Klooster , van den Bos. Net = -$2,500. Net = -$2,500. Over 100 trials. Net = $2,500. Net = $2,500. Why would you make a disadvantageous choice?.

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Iowa gambling task (rats) anxiety and the medial prefrontal cortex

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  1. Iowa gambling task (rats) anxiety and the medial prefrontal cortex de Visser, Baars, van t’ Klooster, van den Bos

  2. Net = -$2,500 Net = -$2,500 Over 100 trials Net = $2,500 Net = $2,500

  3. Why would you make a disadvantageous choice? • People with a “broken” medial Prefrontal Cortex (mPFC) • Emotional control and conflict resolution • Decision making in short… • Malfunction = bad decisions

  4. mPFC • In rats: mPFC involved in anxiety & decisions • May be impaired in people with high anxiety

  5. Things you are allowed to do with rats and not humans… • Artificially deactivate mPFC • Inject GABA agonists • GABA receptor A - muscimol • GABA receptor B - baclofen

  6. Anxiety -Inactivation of mPFC INCREASES anxiety

  7. “Good” choice “Bad” choice Nothing

  8. Nothing 1 pellets: 20% quinine 80% sucrose “Good” choice 3 pellets: 90% quinine 10% sucrose “Bad” choice

  9. 5 days testing 2 days rest 4 days testing 1 2 3 4 5 6 7’ 8’ 9’ 20 trials / day I.C. injection each day 10 trials / day

  10. Trials 41-60 All animals included Median = x “Good performer” = >x “Bad performer” = <x

  11. ???Base line values of what??? • The entire population (good and bad; trial 41-60)? • The respective “good” and “bad” population; trial 41-60? • The individual only; trial 41-60?

  12. Trials 1-60 Trials 61-120 Exploration Defined strategy mPFC Amygdala & ventral striatum Van Den Bos 2007

  13. Defined strategy mPFC Exploration Amygdala & ventral striatum

  14. What is this experiment? Inactivation of mPFC increases anxiety Increased anxiety Poor decision making ????

  15. Current paper Anxiety / fear mPFC Koot poster HPA axis Corticosteroids

  16. Susanne Koot’s poster Corticosterone (stress in a needle)

  17. Net = -$2,500 Net = -$2,500 Over 100 trials Net = $2,500 Net = $2,500

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