1 / 9

Glucosamine

Glucosamine. A Shark’s Tale?. Glucosamine and Chondroitin. What is it? What does it do? Does it work? When should we use it? What is it’s role in management of OA? Should we prescribe it?. What Is It??.

mordecai
Download Presentation

Glucosamine

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Glucosamine A Shark’s Tale?

  2. Glucosamine and Chondroitin • What is it? • What does it do? • Does it work? • When should we use it? • What is it’s role in management of OA? • Should we prescribe it?

  3. What Is It?? • Glucosamine is a sugar - part of the disaccharide units in proteoglycans which are a constitiuent of cartilage.

  4. Glucosamine from shrimp, crab and lobster shells. • Chondroitin from animal cartilage - trachea or shark cartilage.

  5. What does it do? • Glucosamine is part of the GAG in articular cartilage. • Addition of GS increases proteoglycan synthesis. • Restores and maintains cartilage • Antiinflammatory properties.

  6. Does it work? • Cochrane review Towhead et al 2000 • 16 RCTs (2029 pts) - GS effective and safe in OA • 13 RCTS glucosamine better than placebo • 4 RCTs glucosamine vs NSAIDS - superior in 2 equivalent in 2. • Dose 1500mg per day. 6 weeks • OA knee - decreased pain and increased function. • Side effects in 12% - mild GI. • Reginster Lancet 2001 - prospective trial showed modified disease progression • 3 yr study • knee OA (mean 8yr duration age 66) • joint space narrowing reduced. • Improved function - effects after one month • no significant side effects

  7. When should we use it? • OA knee • glucosamine +/- chondroitin • Early stages of disease • Instead of NSAIDs/alongside NSAIDs • Instead of Cox 2 inhibitors.

  8. Role in OA Management • BMJ 4th Dec 2004 • NSAIDS reduce short term pain only slightly more than placebo • Paracetamol first line • Physio/exercise • acupuncture • topical anti inflammatories • GS and C. • Intra-articular injections. • Surgery

  9. Prescribing - BMJ March 19 • Seven Seas GS + C £9.99/30 • Holland and Barrett GS+C £17.99/60 ‘now only’ £8.72 • Glucosamine 500mg £12.49/60 ‘now only’ £4.99

More Related