1 / 29

Organic Macromolecules

Organic Macromolecules. Don’t be scared. Testosterone. Adenosine Triphosphate. Overview. Organic Macromolecules. Biopolymers. Quiz A. Proteins. Carbohydrates. Primary Structures. Quiz C. Quiz B. Monosaccharides. Secondary Structures. Tertiary Structures. Dissacharides.

moswen
Download Presentation

Organic Macromolecules

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Organic Macromolecules Don’t be scared Testosterone Adenosine Triphosphate

  2. Overview Organic Macromolecules Biopolymers Quiz A Proteins Carbohydrates Primary Structures Quiz C Quiz B Monosaccharides Secondary Structures Tertiary Structures Dissacharides Polysaccharides

  3. Quiz A- Basic Organic Chem. Principles • How many bonds do the following atoms form in a covalent compound? a) O b) C c) S d) N e) H f) P 2. Write down the formula of the functional group in each of the following compounds. a) amine b) amide c) alcohol d) carboxylic acid e) ketone f) aldehyde g) ester 3. Give the name for each of the following molecules. a) CHCH e) b) CH3CH2OH f) c) C2H6 g) d)

  4. Quiz A- Basic Organic Chem. Principles • Which of the following molecules might be unsaturated and which are definitely • unsaturated? a) C3H8 b) C4H8 c) C3H4 d) CH3CHCHCH3 5 a) Name the following molecules. i) CH3CH2CH2CH2CH2CH2CH2CH2OH ii) CH3CH2CH2CH2CH2OH iii) CH3CH2OH b) Identify the 2 types of intermolecular bonding present in each of the above molecules. c) Which of the three molecules do you expect to have the highest boiling point temperature? Explain your answer.

  5. Quiz A- Basic Organic Chem. Principles 6. Which type of reactions do you expect the following molecules to undergo? a) CH2CH2 b) CHCH c) CH3CH2CH – CH3 Cl 7. Classify the type of reaction occurring in each of the following cases. a) b) c) 8. Write down all the possible isomers for the compounds which have the following formulae. a) C3H8O a) C4H8

  6. Quiz A- Basic Organic Chem. Principles 9. Identify the functional groups present in the following molecule.

  7. Proteins Most structurally complex organic macromolecules. The building blocks of proteins are amino – acids. = side chain Base Acid 20 amino acids in all 12 the body can synthesize termed non-essential amino acids. 8 that we obtain from our diet termed essential amino acids.

  8. Proteins Non – essential amino acids L–Alanine L–Asparagine L–Aspartic Acid L–Cysteine L–Glutamic Acid L–Glutamine Glycine L–Proline L–Serine L–Tyrosine L–Arginine L–Histidine

  9. Proteins Essential amino acids(must be in the diet) L–Isoleucine L–Leucine L–Lysine L–Methoinine L–Phenylalanine L–Threonine L–Tryptophan L–Valine

  10. Proteins L–Alanine Glycine L–Serine

  11. Proteins – Zwitter Ions All amino acids have the ability to form their corresponding ionic forms as follows. H H O O H H H H N N C C C C H O O H H R R + - O H H N C C O H R

  12. Proteins H Peptide Bond O H H H H H N C C O O O O H H H H R H H H N N N C C C C C C O O O H H H R R R Dehydration

  13. Primary structure of Proteins Reactive ends Peptide Bonds Ala •Ser •Gly

  14. Primary structure of Proteins Try• Lys • Ala •Ser •Gly •Val •Pro ………… ………… Polypeptide (Protein) : 50 – 2000 amino acids

  15. Primary/Tertiary structure of Proteins S S S S L–Cysteine L–Alanine

  16. Secondary structures - -helix Clockwise H O O H 3.6 Amino acids per turn of the helix

  17. Secondary Structures - Zwitter ion formation Some amino acids have extra reactive groups e.g. Carboxylic acid (COOH) – glutamic acid – aspartic acid Amine (NH2) – lysine Lys + - + + Ionic bond - + - + - - H Asp

  18. Top view Secondary structures - -sheets Hydrogen bonding Side view

  19. Tertiary structures • - sheets - helix Has a 3D structure. Contains a combination of secondary structures & primary structures. Structure determined by side – chains.

  20. Quiz B- Proteins 1. Which of the amino-acids have a hydrophobic side-chain? 2. Which of the amino-acids have an acidic side-chain? 3. Which of the amino-acids have an basic side-chain? 4. Which amino acids have a side chain which can become involved in protein hydrogen bonding? 5. Draw the zwitter – ion structure of the amino-acids glycine and serine. • Draw the chemical structure of the tripeptide formed from the following sequence • of amino-acids. •Lys •Tyr Cys Highlight the acidic end of the molecule and the basic end of the molecule.

  21. Carbohydrates Monosaccharides Can be split into two groups : Aldoses & Ketoses. ‘ oses ’  “CH2O” ‘ Ald’  Aldehyde ‘ Ket’  Ketone ‘ C6H12O6’ Ketoses e.g. Fructose Aldoses e.g. Glucose Both Glucose & Fructose are Hex - ‘oses’. Sugars can be 3 to 7 carbons long.

  22. Carbohydrates In aqueous solution sugars form rings e.g. glucose. 1 2 6 3 5 4 4 1 5 2 3 6

  23. Carbohydrates Sugars polymerize via glycosidic 1–4 linkages. H H H H H H H H O O O O H H H H C C C C 5 5 5 5 C C C O O O C O H H H H H H H H H H H H H H H H 1 1 1 4 1 C C C O O O H H H C C C C O H C 4 4 4 O O O C C C C C C O O C C O O 3 3 3 2 2 2 3 2 H H H H H H H H H O O O H O Glycosidic linkage H H H H H 2C6H12O6 C12H22O11 + H2O O Dehydration H

  24. Carbohydrates  glucose + glucose maltose  glucose + fructose sucrose   polysaccharide monosaccharide disaccharide   e.g. Glucose Maltose Starch (100s - 1000s of units)

  25. Carbohydrates The resulting polysaccharide of  1–4 linakges of glucose is starch (storage polysaccharide in plants). Amylose Unbranched starch  1–4 linkages Starch Amylopectin Branched Starch 6 • 1–4 linkages & • 1–6 linkages Branched  1–6 linkages occur every 30 linkages

  26. Carbohydrates Sugars polymerize via glycosidic 1–4 linkages as well. H H H H O O H H C C H H H H 5 5 H H C C O O O O O O H H H H C C H H 4 4 H H 1 1 H C C O O H H C C 5 5 C C O O O O H H H O C C C C H H 3 2 3 2 H H H H 1 1 C C O O H H C C H H H O O 4 4 O O C C C C H H H 3 3 2 2 • 1–4 • Glycosidic • linkage H H H H O O H H H The resulting polysaccharide is cellulose (structural polysaccharide in plants). O H

  27. Quiz C- Macromolecules • The most abundant (by mass) class of organic macromolecules in the biological • world is : A Carbohydrates B Proteins C Nucleic Acids (DNA & RNA) D Lipids • D – ribose is a pentose. It can also be classified as an aldose. Write down a possible • structure for D – ribose. • The monosaccharide threosehas 4 Os ! That is it has 4 oxygen atoms. • What is the molar mass of threose?

  28. Quiz C- Macromolecules A comprehension exercise 4. When one draws the structure of D – glucose there are 2 ways to do it : either a Fischer projection or a Haworth projection. 1 The Fischer projection shows glucose as a linear molecule and the numbering of the carbon atoms is shown on the structure. When it cyclizes it is the oxygen atom on carbon 5 which ends up in the ring. 2 3 4 5 6 6 This ring structure is called the Haworth projection and at equilibrium between the two forms the linear form is only 0.02% of the total glucose present. 5 4 1 2 3

  29. Quiz C- Macromolecules The Haworth projection has the atoms on the RHS of the Fischer projection ‘down’ i.e. below the ring in the Haworth projection, and those on the LHS of the Fischer projection are up (above the ring). The –OH group on carbon 1 (the so called anomeric carbon) can either be up or down, (), or up, (). The  form is about twice as common as the  form. • Draw the Haworth projection of the  form of D – idose, given the Fischer projection • below. b) Draw the Fischer projection of D – galactose given the Haworth projection below. - D -galactose

More Related