1 / 19

Pharmaceutical suspension Nahla S. Barakat, Ph.D King Saud University Dept. of Pharmaceutics 1430-1431

Definition A Pharmaceutical suspension is a coarse dispersion in which internal phase is dispersed uniformly throughout the external phase. The internal phase consisting of insoluble solid particles having a specific range of size which is maintained uniformly throughout the suspending vehicle w

nelia
Download Presentation

Pharmaceutical suspension Nahla S. Barakat, Ph.D King Saud University Dept. of Pharmaceutics 1430-1431

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


    1. Pharmaceutical suspension Nahla S. Barakat, Ph.D King Saud University Dept. of Pharmaceutics 1430-1431 1 312 PHT

    2. Definition A Pharmaceutical suspension is a coarse dispersion in which internal phase is dispersed uniformly throughout the external phase. The internal phase consisting of insoluble solid particles having a specific range of size which is maintained uniformly throughout the suspending vehicle with aid of single or combination of suspending agent. The external phase (suspending medium) is generally aqueous in some instance, may be an organic or oily liquid for non oral use. 2 312 PHT

    3. Classification Based On General Classes Oral suspension Externally applied suspension Parenteral suspension Based On Proportion Of Solid Particles Dilute suspension (2 to10%w/v solid) Concentrated suspension (50%w/v solid) Based On Electrokinetic Nature Of Solid Particles Flocculated suspension Deflocculated suspension Based On Size Of Solid Particles Colloidal suspension (< 1 micron) Coarse suspension (>1 micron) Nano suspension (10 ng) 3 312 PHT

    4. Advantages Suspension can improve chemical stability of certain drug. E.g. Procaine penicillin G Drug in suspension exhibits higher rate of bioavailability than other dosage forms. bioavailability is in following order, Solution > Suspension > Capsule > Compressed Tablet > Coated tablet Duration and onset of action can be controlled. E.g. Protamine Zinc-Insulin suspension Suspension can mask the unpleasant/ bitter taste of drug. E.g. Chloramphenicol palmitate 4 312 PHT

    5. Disadvantages Physical stability, sedimentation and compaction can causes problems. It is bulky sufficient care must be taken during handling and transport. It is difficult to formulate Uniform and accurate dose can not be achieved unless suspension are packed in unit dosage form 5 312 PHT

    6. Features Desired In Pharmaceutical Suspensions The suspended particles should not settle rapidly and sediment produced, must be easily re-suspended by the use of moderate amount of shaking. It should be easy to pour yet not watery and no grittiness. It should have pleasing odour, colour and palatability. Good syringeability. It should be physically, chemically and microbiologically stable. Parenteral/ophthalmic suspension should be sterilizable. 6 312 PHT

    7. Applications Suspension is usually applicable for drug which is insoluble or poorly soluble. E.g. Prednisolone suspension To prevent degradation of drug or to improve stability of drug. E.g. Oxytetracycline suspension To mask the taste of bitter of unpleasant drug. E.g. Chloramphenicol palmitate suspension Suspension of drug can be formulated for topical application e.g. Calamine lotion. Suspension can be formulated for parentral application in order to control rate of drug absorption, E.g. penicillin procaine Vaccines as a immunizing agent are often formulated as suspension. E.g. Cholera vaccine X-ray contrast agent are also formulated as suspension. E.g. Barium sulphate for examination of alimentary tract 7 312 PHT

    8. Theory of Suspensions Sedimentation Behaviour Sedimentation means settling of particle or floccules occur under gravitational force in liquid dosage form. Theory of Sedimentation Velocity of sedimentation expressed by Stoke’s equation V= 2r2 (? s- ? o ) g or V= d2 (? s- ? o ) g 9? 18? 8 312 PHT

    9. Where, vsed. = sedimentation velocity in cm / sec d = Diameterof particle r = radius of particle ? s= density of disperse phase ? o= density of disperse media g = acceleration due to gravity ? = viscosity of disperse medium in poise 9 312 PHT

    10. Factors Affecting Sedimentation Particle size diameter (d) V a d 2 Sedimentation velocity (v) is directly proportional to the square of diameter of particle. Density difference between dispersed phase and dispersion media (?s - ?o) V a (? s - ?o) Generally, particle density is greater than dispersion medium but, in certain cases particle density is less than dispersed phase, so suspended particle floats & is difficult to distribute uniformly in the vehicle. If density of the dispersed phase and dispersion medium are equal, the rate of settling becomes zero. 10 312 PHT

    11. Viscosity of dispersion medium (? ) V a 1/ ?o Sedimentation velocity is inversely proportional to viscosity of dispersion medium. So increase in viscosity of medium, decreases settling, so the particles achieve good dispersion system but greater increase in viscosity gives rise to problems like pouring, syringibility and redispersibility of suspensoin. 11 312 PHT

    12. Advantages and Disadvantages due to viscosity of medium Advantages High viscosity inhibits the crystal growth. High viscosity prevents the transformation of metastable crystal to stable crystal. High viscosity enhances the physical stability. Disadvantages High viscosity hinders the re-dispersibility of the sediments High viscosity retards the absorption of the drug. High viscosity creates problems in handling of the material during manufacturing. 12 312 PHT

    13. I- Sedimentation Parameters Two important parameters are considered: Sedimentation volume (F) or height (H) for flocculated suspensions F = V u / VO -------------- (A) Where, Vu = final or ultimate volume of sediment VO = original volume of suspension before settling. Sedimentation volume is a ratio of the final or ultimate volume of sediment (Vu) to the original volume of sediment (VO) before settling. 13 312 PHT

    14. Sedimentation volume can have values ranging from less than 1 to greater than1; F is normally less than 1. F=1,such product is said to be in flocculation equilibrium, and show no clear supernatant on standing 14 312 PHT

    15. 15 312 PHT

    16. Degree of flocculation (ß) It is a very useful parameter for flocculation 16 312 PHT

    17. The Sedimentation Behavior of Flocculated and Deflocculated Suspensions: Flocculated Suspensions In flocculated suspension, formed flocks (loose aggregates) will cause increase in sedimentation rate due to increase in size of sedimenting particles. Hence, flocculated suspensions sediment more rapidly. Here, the sedimentation depends not only on the size of the flocs but also on the porosity of flocks. In flocculated suspension the loose structure of the rapidly sedimenting flocs tends to preserve in the sediment, which contains an appreciable amount of entrapped liquid. The volume of final sediment is thus relatively large and is easily redispersed by agitation. 17 312 PHT

    18. 18 312 PHT

    19. Deflocculated suspensions In deflocculated suspension, individual particles are settling, so rate of sedimentation is slow which prevents entrapping of liquid medium which makes it difficult to re-disperse by agitation. This phenomenon also called ‘cracking’ or ‘claying’. In deflocculated suspension larger particles settle fast and smaller remain in supernatant liquid so supernatant appears cloudy whereby in flocculated suspension, even the smallest particles are involved in flocs, so the supernatant does not appear cloudy. 19 312 PHT

More Related