1 / 13

Lymphoma

Lymphoma. Dr. Raid Jastania Dec 2006. By the end of this session you should be able to: Discuss the basis of the classification of lymphomas Know the different stages of B lymphocyte List common genetic abnormalities in lymphomas

Download Presentation

Lymphoma

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Lymphoma Dr. Raid Jastania Dec 2006

  2. By the end of this session you should be able to: • Discuss the basis of the classification of lymphomas • Know the different stages of B lymphocyte • List common genetic abnormalities in lymphomas • Classify Hodgkin lymphoma and the difference between the subtypes

  3. Lymphoma • Classification WHO • Lymphoid, Myeloid, Histiocytic • Definitions: • Precursor, mature, stage of differentiation, naïve, peripheral, small cell, large cell • CD’s • Common types: Follicular lymphoma, Diffuse large B cell lymphoma • Age: • Non Hodgkin: 6th- 7th decade • Hodgkin: 3rd decade

  4. Risk factors: • Abnormalities in the immune system. • EBV • HHV8 • Hepatitis C virus • H. pylori

  5. The Journey of the B cells Bone marrow Peripheral blood Lymph node

  6. The Journey of the B cells • Bone marrow- Blast- VDJ gene rearrangement- mature naïve Ig positive cells- IgM, IgD, CD5+ • Antigen- transformation- proliferation- mature B cell IgM • Germinal center maturation, Somatic mutation. • IgG, IgA plasma cells and memory cells. • Plasma cells- bone marrow

  7. The Journey of the B cells • Bone marrow- Blast- VDJ gene rearrangement- mature naïve Ig positive cells- IgM, IgD • CD20, CD19,CD10, TdT, CD5+/- • Antigen- transformation- proliferation- mature B cell IgM • CD20, CD10, Bcl-2 • Germinal center maturation, Somatic mutation. • CD20 • IgG, IgA plasma cells and memory cells. • Loose all the B cell markers CD138+ • Plasma cells- bone marrow

  8. The Journey of the B cells Bone marrow Peripheral blood Lymph node

  9. Genetics • Follicular lymphoma t(14;18) • Bcl-2 over expression • Mantle cell lymphoma: t(11;14) • CyclinD1 over expression • Burkitt lymphoma: t(8;14) • C-myc over expression

  10. Classification • Based on: • Morphology • Immunophenotyping • Clinical presentation • Molecular/cytogenetic findings

  11. Classification • Predominantly disseminated: lymphoma/Leukemia • Primary extranodal • Primary nodal

  12. Classification • Predominantly disseminated: lymphoma/Leukemia • CLL, lymphoplasmacytic lymphoma, Myeloma • Primary extranodal • Marginal zone lymphoma • Primary nodal • Follicular lymphoma, mantle cell lymphoma • Aggressive types • Diffuse large B cell lymphoma, Burkitt lymphoma

More Related