Modeling Platform for Collaboration Zheng Li

1. Modeling Platform for CollaborationZheng Li

2. TERANODE Modeling Platform • TERANODE Design Suite • Biological Modeler • Protocol Modeler • Protocol Player • Closed-loop Edition • Starter Edition (free) • TERANODE Model Server • SDK

3. Teranode History 2005 Q1 V2.5 Launch (Jan) Q4 V2 Launch (Oct) “ Top 100 Innovators” award 2004 Q3 Q2 First Production Sites Q1 Closed Series A Production Clients V1 Released (Feb) Q4 2003 Q3 Signed First Pilot Customer Q2 NIH Grant Awarded ($1.8M over 3yrs) 3 Teranode Patents Pending Q1 Q4 Technology Transfer Complete Q3 Incorporated in Seattle, WA (June) DARPA, NSF, NIH, Intel research funding

4. The Challenge • Closed-loop R&D requires • flexibility and Scalability Flexibility Scalability Existing options force users and managers to choose Documents Desktop apps Databases Custom apps

5. Our Approach Modeling provides both

6. Expensive Programming Long Deployment Cycles Poor Data Mobility Programming-free Common Data Platform Data Mobility Cost-effective Documents LIMS/Databases Models Error-prone Time-consuming Limited Reuse Informatics Choices:Databases, Documents, and Models SCALE Millions ofData Points 1,000’s ofData Points Dynamic Static DATA REQUIREMENTS

7. ReagentProduction PathwayAnalytics SampleManagement Analytics Lab Equipmentand Systems System BiologyRepositories TERANODE Offering TERANODESolutions TERANODEDesign Suite TERANODEModel Server

8. Fragmentation Data Must Be Imported and ExportedBetween Multiple Systems and Applications Programming Changing Data Requirements of Protocols Requires Programming Centralization Data Access and Sharing Requires Database Connection Rigidity Required Schema Standardization Limits Broad Deployments Delayed Results Slow and Costly Development Limited Collaboration Siloed Systems Data Bottlenecks with Current LIMS Bottleneck Impact

9. Protocol Models Automation of Data Management, Integration, and Analytics Real-Time Decision Support Protocol Modeler Visual Protocol Designs by Scientists Captured as Models Rapid Development Protocol Player Design Independent Automation Common Platform VLX Portable Data Format Enabling Data Mobility for Collaboration and Integration Anywhere Data Usage Model-Driven LIMS with Teranode Solution Benefit

10. TERANODE Solution Screening Automation • TERANODE Screening Automation • TERANODE Design Suite • TERANODE Model Server • Screening Models • Integration Libraries • Benefit • Flexible assay design • Data automation • Real-time decision support • No programming required

11. Challenge Solution Results Flexible Assay Design Develop a protein array solution that supports changing assay parameters and automates statistical and regression analysis • TERANODE Design Suite • Custom regression analysis tool • Deployed solution in 7 days • Provided unlimited assay design flexibility • Automated statistical & regression analysis • Enhanced project team collaboration

12. Challenge Solution Results Data Automation Develop a chemical screening solution that automates data processing and IC50 determinations • TERANODE Design Suite & Model Server • MD Spectramax data importer tool • Data dictionary • Deployed solution in 5 days • Automated data processing and analysis • Eliminated data processing errors • Provided real-time assay results

13. Integration Services Interchange with Equipment and External Systems Data Services Data Flow, Storage, and Indexing Compliance Services Audit Trail and Reporting Computation Services Analytics and Simulations Model-Driven Informatics:VLX Models VLX Model

14. Study Design Pathway Analytics Pathway Analytics Diagnostics Sample Mgmt. Sample Mgmt. Process Science Target Id. Assay Design Hit Triage HTS HTS Reagent Prod. Reagent Prod. Versatility of TERANODE Platform

15. Demo