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GLYCOLIPIDS

GLYCOLIPIDS. GLYCOLIPIDS. THEY ARE SUGAR CONTAINING LIPIDS. THEY ARE DERIVED FROM SPHINGOLIPDS. THEY DO NOT CONTAIN PHOSPHATE. GLYCOLIPIDS ARE WIDELY DISTRIBUTED IN OUR BODY,PARTICULARLY IN NERVOUS TISSUE SUCH AS BRAIN. STRUCTURE. GLYCOLIPIDS - CERAMIDE+CARBOHYDRATES.

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GLYCOLIPIDS

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  1. GLYCOLIPIDS

  2. GLYCOLIPIDS • THEY ARE SUGAR CONTAINING LIPIDS. • THEY ARE DERIVED FROM SPHINGOLIPDS. • THEY DO NOT CONTAIN PHOSPHATE. • GLYCOLIPIDS ARE WIDELY DISTRIBUTED IN OUR BODY,PARTICULARLY IN NERVOUS TISSUE SUCH AS BRAIN

  3. STRUCTURE GLYCOLIPIDS - CERAMIDE+CARBOHYDRATES

  4. CLASSIFICATIN CEREBROSIDES SULFATIDES GLOBOSIDES GANGLIOSIDES

  5. CREAMIDE+MONOSACCRIDE CEREBROSIDES IT IS THE SIMPLEST GLYCOLIPID IT IS FOUND IN HIGH CONCENTRATION IN NERVE TISSUE MEMBRANE. Eg.GALACTOCEREBROSIDE

  6. CREAMIDE+MONOSACCHARIDE+SULFATE SULFATIDES THEY ARE CEREBROSIDE IN WHICH THE MONOSACCHARIDE CONTAINS A SULFATE ESTER Eg. SULFOGALACTOCERAMIDE

  7. CERAMIDE+OLIGOSACCHARIDE GLOBOSIDE THEY ARE IMPORTANT CONSTITUENT OF RBC MEMBRANE AND DETERMINANTS OF ABO BLOOD GROUP SYSTEM.

  8. CEREBROSIDE+OLIGOSACCHARIDE+NANA GANGLIOSIDES THEY ARE INVOLVED IN CELL MEMBRANE RECEPTORS FOR CERTAIN POLYPEPTIDE HORMONES.

  9. FUNCTIONS THEY ARE IMPORTANT IN CELL ADHESION RECOGNITION. AS RECEPTORS FOR BACTERIAL TOXINS (Eg. THE TOXIN THAT COLERA). ABO BLOOD GROUP SUBSTANCES. IMPORTANT CONSTITUENTS OF THE NERVOUS TISSUE SUCH AS BRAIN.

  10. THE PLASMA MEMBRANE • THEY ARE IMPORTANT CONSTIUENT OF OUTER LEAFLET OF CELL MEMBARNE

  11. ABO BLOOD GOUP ON CELL MEMEBRANE OF RED BLOOD CELL OLIGOSACCRIDES THAT DETERMINE THE SPECIFC NATUER OF THE ABO SUBSTANCES APPEAR TOBE PRESENT IN GLYCOSPHINGOLIPIDS

  12. BIO-SYNTHESIS SPHINGOSINE UDP-GALACTOSE CERAMIDE UDP-GLUCOSE UDP UDP GALACTOCEREBROSIDE GLUCOCRERBROCYTE UDP-SUGARS PAPS UDP-SUGARS CMP-NANA SULFATIDES GANGLIOSIDE GLOBOSIDE

  13. BIO-SYNTHESEIS FORMED FROM CERAMITE. THE AMINO GROUP OF SPHINGOSINE BACK BONE IS ACYLATED BY A C FATTYACID OCCUR IN MANY GLYCOSPHINGOLIPIDS ,CEREBROSIDE,SULFATEIDES,GLBOSIDES,GANGLOSIDES,ARE THE DIFFERENT TYPES OF GLYCOLIPIDS. IN A CEREBROSIDE GLUCOSE OR GALACTOSE IS LINKED TO THE TERMINAL GROUP OF CERAMIDE TO FORMGLUCOCEREBROSIDE. 24

  14. BIO-SYNTHESEIS CERAMIDE REACTS WITH UDP-GLUCOSE TO FORM GLUCOCERBROSIDE. GLALCTOCEREBROSIDE REACTS WITHACTIVE SULPHATE 3’-PHOSPHOADENOSINE 5’-PHOSPHOSULFATE TO FORM SULFATIDES.ADDITIONAL SUGARS MAY BE ADDED TO CERAMITES TO FORM GLOBOSIDES

  15. GLYCOLIPIDS STORAGE DISEASES GAUCHER’S DISESSE TAY-SACHS DISEASE THEY ARE DUE TO GENETIC DEFECT IN THE PATHWAY OF GLYCOLIPID DEGRADATION IN THE LYSOSOMES

  16. THANK YOU

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